Diet and Optimum Health September 13-16, 2017, in Corvallis, Oregon, USA
All conference sessions are held at the CH2M Hill Alumni Center on the Oregon State University campus.
The conference booklet is available for download (PDF).
Full speaker abstracts can be found with their associated sessions below, or on the Abstracts page.


   
7:00 AM Registration begins at the CH2M Hill Alumni Center
7:30 - 8:30 Breakfast provided at the CH2M Hill Alumni Center
8:30 - 9:00 Welcome
Maret Traber, PhD, Conference Chair
Fred Stevens, PhD, Interim Director
Linus Pauling Institute, Oregon State University
  Proclamation
Biff Traber, Mayor of Corvallis
A Tribute to Balz Frei
Chair: Tory Hagen, PhD, Linus Pauling Institute, Oregon State University
9:00 - 9:30

Redox control of vascular function: Adventures with Balz Frei
John F. Keaney, Jr., MD
University of Massachusetts Medical School, Worcester, MA

9:30 - 10:00

From DIM to SMaRT in 30 years
Roderick Dashwood, PhD
Texas A&M University, Houston, TX

10:00 - 10:30

The role of bioactives in redox regulation
Helmut Sies, MD
Heinrich Heine Universität, Düsseldorf, Germany

10:30 - 11:00 Coffee/Tea Break
Dietary Components and the Micrbiome
Chair: Fritz Gombart, PhD, Linus Pauling Institute, Oregon State University
11:00 - 11:30 Diet, evolution, and the microbiome
Jens Walter, PhD
University of Alberta, Edmonton, AB, Canada
11:30 - 12:00 Botanical therapeutics and the microbiome
Diana Roopchand, PhD
Rutgers, The State University of New Jersey, New Brunswick, NJ
12:00 - 1:30 Lunch provided at the Alumni Center
Lipid Metabolism
Chair: Fred Stevens, PhD, Linus Pauling Institute, Oregon State University
1:30 - 2:00 Cardiac benefits of medium-chain triglyceride supplements: Odd versus even
Melanie B. Gillingham, PhD, RD
Oregon Health & Science University, Portland, OR
2:00 - 2:30 Phenotypic flexibility: A new way to quantify the effects of food and nutrition on health
Suzan Wopereis, PhD
Netherlands Organization for Applied Scientific Research (TNO), Zeist, The Netherlands
2:30 - 3:00 Phospholipid oxygenation products and their role as potential proximate signals of ferroptotic death
Valerian E. Kagan, PhD, DSc
University of Pittsburgh, Pittsburgh, PA
3:00 - 3:30 Coffee/Tea Break
Update on Vitamin E
Chair: Manfred Eggersdorfer, PhD, DSM Nutritional Products, Basel, Switzerland
3:30 - 4:00 Vitamin E regulation of the development of allergies and allergic asthma immunopathogenesis​
Joan Cook-Mills, PhD
Northwestern University, Chicago, IL
4:00 - 4:30 Alpha-tocopherol bioavailability is lower in adults with metabolic syndrome
Richard S. Bruno, PhD, RD
The Ohio State University, Columbus, OH
4:30 - 5:00 Biokinetics of intravenous vitamin E
Maret Traber, PhD
Linus Pauling Institute, Oregon State University, Corvallis, OR
5:00 - 5:30 Round-Table Discussion: Time for a new RDA?
 
5:30 - 7:00 Welcome Reception and Poster Presentations (abstracts available here)
   
   
6:00 AM Organized Walk/Run
7:00 - 8:00 Breakfast provided at the Alumni Center
Bioactives and Cancer Prevention
Chair: Arup Indra, PhD, College of Pharmacy and Linus Pauling Institute, Oregon State University
8:00 - 8:30 Cancer chemoprevention by dietary indoles
David Williams, PhD
Linus Pauling Institute, Oregon State University, Corvallis, OR
8:30 - 9:00 Diet, epigenetics, and cancer prevention
Emily Ho, PhD
Linus Pauling Institute, Oregon State University, Corvallis, OR
9:00 - 9:30 Can an epigenetics diet prevent cancer?
Trygve Tollefsbol, PhD, DO 
University of Alabama at Birmingham, Birmingham, AL
9:30 - 10:00 Coffee/Tea Break
Metabolism of Bioactives (Polyphenols)
Chair: Neil Shay, PhD, Food Science and Technology, Oregon State University
10:00 - 10:30 The metabolome of [2-14C](-)-epicatechin in humans: Implications for the assessment of efficacy, safety, and mechanisms of action of polyphenolic bioactives
Hagen Schroeter, PhD
University of California, Davis, CA
10:30 - 11:00 Identification and quantification of novel cranberry-derived (poly)phenol metabolites
Ana Rodriguez-Mateos, PhD
King's College, London, UK
11:00 - 11:30 Use of nutrigenomics to decipher mechanisms of action of polyphenols mediating their cardiovascular protective effect
Dragan Milenkovic, PhD
French National Institute for Agricultural Research (INRA), Clermont-Ferrand, France
11:30 - 12:00 Athero-protective actions of flavonoids
Roland Stocker, PhD
Victor Chang Cardiac Research Institute, Darlinghurst, NSW, Australia
12:00 - 1:30 Lunch provided at the Alumni Center
NUTRITION AND BRAIN HEALTH
Chair: Gene Bowman, ND, MPH, Nestle Institute of Health Sciences, Lausanne, Switzerland
1:30 - 2:00 Centella asiatica, an edible herb for Alzheimer's disease?
Amala Soumyanath, PhD
Oregon Health & Science University, Portland, OR
2:00 - 2:30 Effects of diet on gut-brain interactions
Kathy Magnusson, DVM, PhD
Linus Pauling Institute, Oregon State University, Corvallis, OR
2:30 - 3:00 Oxidized lipids in brain trauma
Hülya Bayīr, MD
Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA
3:00 - 3:30 Vitamin C deficiency and synaptic glutamate toxicity in seizures and neurodegeneration
Fiona E. Harrison, PhD
Vanderbilt University Medical Center, Nashville, TN
3:30 - 4:00 Coffee/Tea Break
Lightning Talks

Chair: Viviana Perez, PhD, Linus Pauling Institute, Oregon State University

4:00 - 4:10 Green tea extract improves microbiota composition and intestinal barrier function to prevent dietary fat-induced obesity by limiting gut-derived endotoxin translocation and adipose TLR4/NFkB inflammation
Priyankar Dey, PhD, The Ohio State University
4:10 - 4:20 Diet-gut microbiota interactions mediated by hop-derived xanthohumols in a mouse obesity model
Johana Revel, PhD, Linus Pauling Institute, Oregon State University
4:20 - 4:30 A novel nutritional formulation containing the prebiotic human milk oligosaccharide 2'-fucosyllactose reduces gastrointestinal symptoms and beneficially alters the gut microbiome in adults with gastrointestinal dysfunction
Jennifer Ryan, ND, National University of Natural Medicine
4:30 - 4:40 Ascorbate deficiency and mitochondrial dysfunction in the APP/PSEN1 mouse models of Alzheimer's disease
Shilpy Dixit, Vanderbilt University
4:40 - 4:50

Local sustained delivery of 1α,25(OH)2D3 by nanofiber wound dressings induces human cathelicidin antimicrobial peptide expression both in vitro and in vivo
Yang Zhang, Linus Pauling Institute, Oregon State University

 5:00 - 7:00 Posters available for perusal
6:00 AM Organized Walk/Run
7:00 - 8:00 Breakfast provided at the Alumni Center
Mechanisms of Vitamin C in Cancer
Chair: Anitra Carr, PhD, University of Otago, Christchurch, New Zealand
8:00 - 8:30 Ascorbic acid physiology and pharmacology: Foundations for cancer and sepsis therapies
Mark A. Levine, MD 
NIDDK, National Institutes of Health, Bethesda, MD
8:30 - 9:00 Vitamin C-dependent regulation of the hypoxic response in cancer
Margreet Vissers, PhD
University of Otago, Christchurch, New Zealand
9:00 - 9:30 Vitamin C as a multi-targeting anti-cancer agent
Qi Chen, PhD 
University of Kansas Medical Center, Kansas City, KS
9:30 - 10:00 Vitamin C and bone marrow stem cell transplantation
Gerard Bos, PhD 
Maastricht University Medical Centre, Maastricht, The Netherlands
10:00 - 10:30 Coffee/Tea Break
IV Vitamin C Therapy in Cancer
Chair: Ramesh Natarajan, PhD, Virginia Commonwealth University, Richmond, VA

10:30 - 11:00

The chemical biology of IV-C in cancer treatment: Basic science to clinical trials
Garry Buettner, PhD
The University of Iowa, Iowa City, IA

11:00 - 11:30

Optimizing vitamin C impact in treating chronic disease
Thomas E. Levy, MD, Peakenergy.com
Standing in for Gaofeng Wang, PhD, University of Miami
11:30 - 12:00

 

IV vitamin C and chemotherapy in ovarian cancer
Jeanne Drisko, MD
University of Kansas Medical Center, Kansas City, KS
12:00 - 12:30 Challenges of natural product drug development
Channing J. Paller, MD 
Johns Hopkins University School of Medicine, Baltimore, MD
12:30 - 2:00 Lunch provided at the Alumni Center
IV Vitamin C Therapy in Sepsis
Chair: Margreet Vissers, PhD, University of Otago, Christchurch, New Zealand
2:00 - 2:30 IV vitamin C in pre-clinical sepsis and trauma models
Ramesh Natarajan, PhD
Virginia Commonwealth University, Richmond, VA
2:30 - 3:10 Intravenous vitamin C as therapy for sepsis-induced acute lung injury
Alpha A. (Berry) Fowler, III, MD
Virginia Commonwealth University, Richmond, VA
3:10 - 3:40 Vitamin C requirements and mechanisms of action in severe infection
Anitra Carr, PhD
University of Otago, Christchurch, New Zealand
3:40 - 4:20 Vitamin C, hydrocortisone, and thiamine for the treatment of severe sepsis and septic shock:  The metabolic resuscitation protocol
Paul Marik, MD
Eastern Virginia Medical School, Norfolk, VA
4:20 - 4:30 Conference farewell 
Maret Traber, PhD, Conference Chair 
Linus Pauling Institute, Oregon State University, Corvallis, OR
6:30 - 9:30 20th Anniversary, LPI Reunion, and Conference Banquet at the Alumni Center
Bioactives

Poster Abstract 1
Design and development of a reporter plasmid for high-throughput screening of botanical extracts and small molecule libraries to discover prenylated flavonoid ligands of FXR
Isabelle Logan, Linus Pauling Institute, Oregon State University

Poster Abstract 2
Effects of nitrate and nitrite exposure on zebrafish behavior and brain metabolic phenotyping
Manuel Garcia-Jaramillo, PhD, Linus Pauling Institute, Oregon State University

Poster Abstract 3
Metabolism of xanthohumol and 8-prenylnaringenin by intestinal microbiota
Ines Paraiso, Linus Pauling Institute, Oregon State University

Poster Abstract 4
Characterization and quantification of phytochemical constituents in the medicinal herb Centella asiatica by high-resolution mass spectrometry
Armando Alcazar Magana, Oregon State University

Poster Abstract 5
Profiling of specific metabolic signatures in deuterium labeled and unlabeled broccoli sprouts with X13CMS
Jaewoo Choi, PhD, Linus Pauling Institute, Oregon State University

Poster Abstract 6
Diet–gut microbiota interactions mediated by hop-derived xanthohumols in a mouse obesity model
Johana Revel, Linus Pauling Institute, Oregon State University

Poster Abstract 7
A novel nutritional formulation containing the prebiotic human milk oligosaccharide 2’-fucosyllactose reduces gastrointestinal symptoms and beneficially alters the gut microbiome in adults with gastrointestinal dysfunction
Jennifer Ryan, ND, National University of Natural Medicine

Poster Abstract 8
Supplementation of mice fed a high fat diet with xanthohumol and its derivatives changes the composition of the fecal microbiota and is associated with observed metabolic improvements
Yang Zhang, Linus Pauling Institute, Oregon State University

Poster Abstract 9
Hepatic and gut microbial metabolism of the hop nutraceutical, xanthohumol, in humans
Lea-Sophie Ullrich, Linus Pauling Institute, Oregon State University

Poster Abstract 10
Green tea extract improves microbiota composition and intestinal barrier function to prevent dietary fat-induced obesity by limiting gut-derived endotoxin translocation and adipose TLR4/NFκB inflammation
Priyankar Dey, PhD, The Ohio State University

Poster Abstract 11
Green tea treatment in obese mice with nonalcoholic steatohepatitis lowers hepatic NFκB activation in association with altered relative abundance of phosphatidylcholine and bile acid metabolites
Geoffrey Sasaki, The Ohio State University

Poster Abstract 12
Effects of dietary resveratrol on the fecundity of a novel model, Nothobranchius guentheri
Andrew Drake, Linus Pauling Institute, Oregon State University

Poster Abstract 13
Antiviral activity of scorpion venom peptides
Victor Huerta, PrevenOx Orthomolecular Biomedical Research

Poster Abstract 14
To whom the side effect of licorice, pseudoaldosteronism, will occur: Case-control study
Tetsuhiro Yoshino, Linus Pauling Institute, Oregon State University

Healthy Diets

Poster Abstract 20
Optimizing gut flora for optimum health and disease prevention
Anyanwu Chukwudi, University of Nigeria

Poster Abstract 21
Eat more plants! A community-based approach to early nutrition education
Megan Kuntz, Western University of Health Sciences, COMP-Northwest

Poster Abstract 22
Rural kid’s cooking camp emphasizing a plant-based diet survey study
Leah Nelson, Western University of the Health Sciences, COMP-Northwest

Poster Abstract 23
Assessment of gut microbiome role in diet-related changes in cognition
Kathy Magnusson, DVM, PhD Linus Pauling Institute, Oregon State University

Poster Abstract 24
The cathelicidin antimicrobial peptide gene alters the gut microbiota of mice
Miles Rouches, Oregon State University

Poster Abstract 25
Dairy milk, regardless of fat content, protects against postprandial hyperglycemia-mediated oxidative stress, dysregulated arginine metabolism and increases in endothelin-1 in prediabetic adults
Joshua McDonald, The Ohio State University

HealthSPAN and Aging

Poster Abstract 30
Age-related loss of hepatic Nrf2 protein homeostasis is attributed to heightened expression of miR-146a
Nicholas Thomas, PhD, Linus Pauling Institute, Oregon State University

Poster Abstract 31
The role of proteostasis in protein aggregation in long-lived species
Bharath Sunchu, Linus Pauling Institute, Oregon State University

Poster Abstract 32
Dietary restriction improves cognitive performance and maintains hepatic Sirt7 levels in Nothobranchius guentheri, a short-lived model of aging
Kate Petersen Shay, PhD, Linus Pauling Institute, Oregon State University

Poster Abstract 33
Long-term supplementation with a novel nutrient blend mimics calorie restriction transcriptomics in multiple tissues of old mice
Angela Mastaloudis, PhD, Nu Skin Enterprises

Poster Abstract 34
Rapamycin inhibits the secretory phenotype of senescent cells by an Nrf2-independent mechanism
Rong Wang, PhD, Linus Pauling Institute, Oregon State University

Poster Abstract 35
Safe and proven daily actions to improve your healthspan
Alfred “Roc” Ordman, PhD, Beloit College

Poster Abstract 36
Cellular Senescence Contributes to Hepatic “Inflamm-aging”
Amanda Kelley, Linus Pauling Institute, Oregon State University

Vitamins and Minerals

Poster Abstract 40
Adverse effects of arsenic exposure and zinc deficiency on pancreatic beta cells and insulin production
Annie Cao, Linus Pauling Institute, Oregon State University

Poster Abstract 41
Adverse consequences of zinc deficiency and arsenic exposure to zebrafish development
Laura Beaver, PhD, Linus Pauling Institute, Oregon State University

Poster Abstract 42
Interactions between arsenic exposure and zinc deficiency on zinc status, oxidative stress, and inflammatory response
Carmen Wong, PhD, Linus Pauling Institute, Oregon State University

Poster Abstract 43
Ascorbate deficiency and mitochondrial dysfunction in the APP/PSEN1 mouse models of Alzheimer’s disease
Shilpy Dixit, Vanderbilt University

Poster Abstract 44
Local sustained delivery of 1α,25(OH)2D3 by nanofiber wound dressings induces human cathelicidin antimicrobial peptide expression both in vitro and in vivo
Yang Zhang, Linus Pauling Institute, Oregon State University
Poster Abstract 45
Chronic vitamin E deficiency in adult zebrafish dysregulates brain lipids, energy metabolism, and cognitive function
Scott Leonard, MS, Linus Pauling Institute, Oregon State University

Cancer

Poster Abstract 50
Application of Quantitative Redox Biology to basic research on the use of pharmacological ascorbate in cancer therapy
Garry Buettner, PhD, The University of Iowa

Poster Abstract 51
4D quantitative image analysis of cancer cell invasion in a brain microenvironment using ImageJ software
John Gamble, Oregon State University

Poster Abstract 52
Primary T-cell lymphoblastic leukemia (T-ALL) xenotransplant in zebrafish as a model for chemoprevention
Youngjoo Lee, Linus Pauling Institute, Oregon State University

Poster Abstract 53
The aryl hydrocarbon receptor mediates growth-inhibitory effects of SU5416 in hepatoma cells
Hyo Sang Jang, Oregon State University

Poster Abstract 54
Targeting therapy resistant cancer through Bcl-2 functional conversion
Martin Pearce, Oregon State University

Poster Abstract 55
AhR-dependent induction of p27Kip1 by select AhR ligands
Veronica Puig-Sanvicens, PhD, Oregon State University

Poster Abstract 56
Grain legume consumption may provide chemo-preventive effects on incident and prevalent colorectal adenoma and colorectal cancer: A meta-analysis of human studies
Thushanthi Perera, Linus Pauling Institute, Oregon State University

Poster Abstract 57
Chemopreventive response markers to navy bean extract in a mouse model of inflammation-induced colorectal cancer
Gerd Bobe, PhD, Linus Pauling Institute, Oregon State University