Diet and Optimum Health September 13-16, 2017, in Corvallis, Oregon, USA
The conference will be held at the CH2M Hill Alumni Center on the Oregon State University campus.

Wednesday, September 13, 2017

8:00 AM Registration begins at the Alumni Center
A Tribute to Balz Frei
9:00 - 10:00


10:00 - 10:30

The role of bioactives in redox regulation 
Helmut Sies, PhD
Heinrich Heine Universität, Düsseldorf, Germany

10:30 - 11:00 Coffee/Tea Break
Dietary Components and the Micrbiome
11:00 - 11:30 Diet, evolution, and the microbiome
Jens Walter, PhD
University of Alberta, Edmonton, AB, Canada
11:30 - 12:00 Botanical therapeutics and the microbiome
Diana Roopchand, PhD
Rutgers, The State University of New Jersey, New Brunswick, NJ
12:00 - 1:30 Lunch provided at Alumni Center
Lipid Metabolism
1:30 - 2:00 Cardiac benefits of medium chain triglyceride supplements: Odd versus even
Melanie B. Gillingham, PhD, RD
Oregon Health & Sciences University, Portland, OR
2:00 - 2:30 Quantifying phenotypic flexibility as the response to a high-fat challenge test in different states of metabolic health
Suzan Wopereis, PhD
Netherlands Organization for Applied Scientific Research (TNO), Zeist, The Netherlands
2:30 - 3:00 Phospholipid oxygenation products and their role as potential proximate signals of ferroptotic death
Valerian E. Kagan, PhD, DSc
University of Pittsburgh, Pittsburgh, PA
3:00 - 3:30 Coffee/Tea Break
Update on Vitamin E
3:30 - 4:00 The alpha-tocopherol form of vitamin E reverses age-associated susceptibility to streptococcus pneumoniae lung infection by modulating pulmonary neutrophil recruitment
Simin Meydani, DVM, PhD
Jean Mayer USDA HNRCA at Tufts University, Boston, MA
4:00 - 4:30 Vitamin E regulation of the development of allergies and allergic asthma immunopathogenesis​
Joan Cook-Mills, PhD
Northwestern University, Chicago, IL
4:30 - 5:00 Alpha-tocopherol bioavailability is lower in adults with metabolic syndrome
Richard S. Bruno, PhD, RD
The Ohio State University, Columbus, OH
5:00 - 5:30 Round-Table Discussion: Time for a new RDA?
5:30 - 7:00 Welcome Reception and Poster Presentations

Thursday, September 14, 2017

6:00 AM Organized Walk/Run
7:00 - 8:00 Breakfast provided at Alumni Center
Bioactives and Cancer Prevention
8:00 - 8:30 Cancer chemoprevention by dietary indoles
David Williams, PhD
Linus Pauling Institute, Oregon State University, Corvallis, OR
8:30 - 9:00 Diet, epigenetics, and prostate cancer
Emily Ho, PhD
Linus Pauling Institute, Oregon State University, Corvallis, OR
9:00 - 9:30 Can an epigenetics diet prevent cancer?
Trygve Tollefsbol, PhD, DO 
University of Alabama at Birmingham, Birmingham, AL
9:30 - 10:00 Coffee/Tea Break
Metabolism of Bioactives (Polyphenols)
10:00 - 10:30 The metabolome of [2-(14)C](-)-epicatechin in humans: Implications for the assessment of efficacy, safety, and mechanisms of action of polyphenolic bioactives
Hagen Schroeter, PhD
University of California, Davis, CA
10:30 - 11:00 Identification and quantification of novel cranberry-derived plasma and urinary (poly)phenols
Ana Rodriguez-Mateos, PhD
Kings College, London, UK
11:00 - 11:30 Use of nutrigenomics to decipher mechanisms of action of polyphenols mediating their cardiovascular protective effect
Dragan Milenkovic, PhD
French National Institute for Agricultural Research (INRA), Clermont-Ferrand, France
11:30 - 12:00 Athero-protective action of polyphenols
Roland Stocker, PhD
Victor Chang Cardiac Research Institute, Darlinghurst, NSW, Australia
12:00 - 1:30 Lunch provided
Diet, Neuropathy, and Dementia
1:30 - 2:00 Nicotinamide riboside: From discovery to human translation
Charles Brenner, PhD
University of Iowa, Iowa City, IA
2:00 - 2:30 Effects of diet on gut-brain interactions
Kathy Magnusson, DVM, PhD
Linus Pauling Institute, Oregon State University, Corvallis, OR
2:30 - 3:00 The dynamic blood brain barrier
John F. Keaney, Jr., MD
University of Massachusetts Medical School, Worcester, MA
3:00 - 3:30 Role of vitamin C and synaptic glutamate toxicity in seizures, particularly in neurodegenerative conditions
Fiona E. Harrison, PhD
Vanderbilt University Medical Center, Nashville, TN
3:30 - 4:00 Coffee/Tea Break
Oral Abstract Presentations
4:00 - 5:30 Lightning Talks
Six oral presentations from submitted abstracts, 10 minutes each
 5:30 - 7:00 LPI Reunion and 20th Anniversary Celebration Reception

Friday, September 15, 2017

6:00 AM Organized Walk/Run
7:00 - 8:00 Breakfast provided
Mechanisms of Vitamin C in Cancer
8:00 - 8:30 Ascorbate-induced cell death in human pancreatic cancer cells: Role of Bcl-2, Beclin 1 and autophagy 
Qi Chen, PhD 
University of Kansas Medical Center, Kansas City, KS
8:30 - 9:00 Vitamin C-dependent regulation of the hypoxic response in cancer 
Margreet Vissers, PhD 
University of Otago, Christchurch, New Zealand
9:00 - 9:30 Epigenetic treatment of cancer by vitamin C
Gaofeng Wang, PhD
University of Miami Miller School of Medicine, Miami, FL
9:30 - 10:00 Vitamin C and bone marrow stem cell transplantation
Gerard Bos, PhD 
Maastricht University Medical Centre, Maastricht, The Netherlands
10:00 - 10:30 Coffee/Tea Break
IV Vitamin C Therapy in Cancer

10:30 - 11:00

The chemical biology of IV-C in cancer treatment: Basic science to clinical trials
Garry Buettner, PhD 
The University of Iowa, Iowa City, IA

11:00 - 11:30

IVC-generated hydrogen peroxide in cancer treatment 
Mark A. Levine, MD 
NIDDK, National Institutes of Health, Bethesda, MD
11:30 - 12:00


IVC and chemotherapy in ovarian cancer 
Jeanne Drisko, MD
University of Kansas Medical Center, Kansas City, KS
12:00 - 12:30 Challenges of conducting clinical trials of natural products to combat cancer 
Channing J. Paller, MD 
Johns Hopkins University School of Medicine, Baltimore, MD
12:30 - 2:00 Lunch provided
IV Vitamin C Therapy in Sepsis
2:00 - 2:30 IVC in pre-clinical sepsis models
Ramesh Natarajan, PhD
Virginia Commonwealth University, Richmond, VA
2:30 - 3:00 IVC in human sepsis and acute lung injury
Alpha A. (Berry) Fowler, III, MD
Virginia Commonwealth University, Richmond, VA
3:00 - 3:30 Vitamin C requirements and mechanisms of action in severe sepsis
Anitra Carr, PhD
University of Otago, Christchurch, New Zealand
3:30 - 4:10 Hydrocortisone, vitamin C, and thiamine for the treatment of severe sepsis and septic shock
Paul Marik, MD
Eastern Virginia Medical School, Norfolk, VA
6:00 - 9:00 Banquet

Saturday, September 16, 2017

9:00am - 12:00 Public Session (TBA)