Principal Investigator, Linus Pauling Institute
Director, Nutrition Graduate Program, College of Public Health and Human Sciences
Professor, School of Biological and Population Health Sciences
Office: 107A Milam Hall
Email Address: email@example.com
Mailing/Express Delivery Address:
Donald B. Jump, Ph.D.
College of Public Health and Human Sciences
Oregon State University
107A Milam Hall
Corvallis, OR 97331
The type and quantity of dietary fat we ingest impacts the onset and progression of chronic diseases, e.g., atherosclerosis, diabetes and obesity. Our studies focus on the impact dietary fat has on hepatic gene expression, i.e., diet-gene interactions. Over the years we have defined mechanisms by which specific dietary fats regulate gene transcription by controlling the activity or abundance of key transcription factors. These transcription factors target genes involved in hepatic carbohydrate and lipid metabolism. Since the liver plays a central role in whole body carbohydrate and lipid metabolism, our studies reveal how diet can modify liver function, which in turn affects our health and the onset of metabolic diseases.
||Ph.D., Biochemistry, Georgetown University
||M.S., Biology, Rutgers University
||B.S., Biology, Delaware State College
||Professor, School of Biological and Population Health Sciences, Oregon State University, Corvallis, OR
||Principal Investigator, Linus Pauling Institute, Oregon State University, Corvallis, OR
||Professor, Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR
||Professor, Departments of Physiology, Biochemistry and Molecular Biology, Michigan State University, E. Lansing, MI
||Associate Chair of Physiology, and Director of the Graduate Program for Physiology, Michigan State University, E. Lansing, MI
||Associate Professor, Joint Appointment, Department of Biochemistry Michigan State University, MI
||Associate Professor (with tenure), Department of Physiology, Michigan State University, East Lansing, MI
||Assistant Professor (tenure stream), Department of Physiology, Michigan State University, East Lansing, MI
||Assistant Professor, Departments of Medicine, Genetics and Cell Biology, University of Minnesota Medical School, Minneapolis, MN
||Post-doctoral Fellow, Department of Medicine, Division of Endocrinology and Metabolism, University of Minnesota, Minneapolis, MN
||Pre-doctoral Research Fellow, Department of Biochemistry, Georgetown University, Washington, D. C.
||Research Assistant, Agricultural Chemistry Department, Oregon State University, Corvallis, OR
||Research Assistant, Oncology Section, Institute for Medical Research, Camden, NJ
||Osborne and Mendel Award, American Society for Nutrition
||Keynote speaker: 1st Lipidomic Congress, Paris, France
||Visiting Professor, Nutrition Council, Iowa State University, Ames, IA
||Speaker at the National Academy of Science for National Research Council, Wash., D.C.
||Jean Andrews Visiting Professor, Nutritional Science Program, University of Texas-Austin
||National Research Service Award (NIH-T32, 1979-1981), University of Minnesota
Professional Activities and Memberships
||American Society of Nutritional Sciences
||American Society of Biochemistry and Molecular Biology
Jump DB, Depner CM, Tripathy S & Lytle, KA. (2016). Impact of dietary fat on the development of non-alcoholic fatty liver disease (NAFLD) in Ldlr-/-mice. Proceedings of the Nutrition Society 75: 1-9.
Lytle KA & Jump DB. (2016). Is western diet-induced nonalcoholic steatohepatitis in Ldlr-/- mice reversible? PLoS One 11(1): e0146942.
Jump DB. (2016). Chronic fatty liver disease. ASBMB Today-Lipid News 15 (4), 6 & 8.
Lytle KA, Depner CM, Wong CP & Jump DB. (2015). Docosahexaenoic acid attenuates western diet-induced hepatic fibrosis in Ldlr-/- mice by targeting the TGFb-Smad3 pathway. Journal of Lipid Research 56: 1936-1946.
Jump DB, Depner CM, Tripathy S & Lytle KA. (2015). Potential for Dietary w3 fatty acids to prevent nonalcoholic fatty liver disease and reduce the risk of primary liver cancer. Advances in Nutrition 6: 694-702.
Tripathy S, Lytle KA, Stevens RD, Bain JR, Newgard CB, Greenberg AS, Huang LS, Jump DB. (2014) Fatty acid elongase-5 (Elovl5) regulates hepatic triglyceride catabolism in obease C57BL/6J mice. J Lipid Res 55:1448-1464.
Lebold KM, Kirkwood JS, Taylor AW, Choi J, Barton CL, Miller GW, Du JL, Jump DB, Stevens JF, Tanguay RL, Traber MG. (2013) Novel liquid chromatography-mass spectrometry method shows that vitamin E deficiency depletes arachidonic and docosahexaenoic acids in zebrafish (Danio rerio) embryos. Redox Biol 2:105-113.
Depner CM, Traber MG, Bobe G, Kensicki E, Bohren KM, Milne G, Jump DB. (2013) A metabolomic analysis of omega-3 fatty acid-mediated attenuation of western diet-induced nonalcoholic steatohepatitis in LDLR-/- mice. PLoS One 8:e83756.
Jump DB, Tripathy S, Depner CM. (2013) Fatty Acid-regulated transcription factors in the liver. Ann Rev of Nutr 33:249-269.
Depner CM, Philbrick KA, Jump DB. (2013) Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr-/- mouse model of western diet-induced nonalcoholic steatohepatitis. J Nutr 143:315-323.
Tripathy S, Jump DB. (2013) Elovl5 regulates the mTORC2-Akt-FOXO1 pathway by controlling hepatic cis-vaccenic acid synthesis in diet-induced obese mice. J Lipid Res 54:71-84.
Jump DB, Depner CM, Tripathy S. (2012) Omega-3 fatty acid supplementation and cardiovascular disease. J Lipid Res 53:2525-2545.
Depner CM, Torres-Gonzalez M, Tripathy S, Milne G, Jump DB. (2012) Menhaden oil decreases high-fat diet-induced markers of hepatic damage, steatosis, inflammation, and fibrosis in obese Ldlr-/- mice. J Nutr 142:1495-1503.
Lebold KM, Jump DB, Miller GW, Wright CL, Labut EM, Barton CL, Tanguay RL, Traber MG. (2011) Vitamin E deficiency decreases long-chain PUFA in zebrafish(Danio rerio). J Nutr 141:2113-2118.
Jump DB, Torres-Gonzalez M, Olson LK. (2011) Soraphen A, an inhibitor of acetyl CoA carboxylase activity, interferes with fatty acid elongation. Biochem Pharmacol 81:649-660.
Jump DB. (2011) Fatty acid regulation of hepatic lipid metabolism. Curr Opin Clin Nutr Metab Care 14:115-120.