Principal Investigator, Linus Pauling Institute
Endowed Director, Moore Family Center for Whole Grain Foods, Nutrition and Preventive Health
Professor, College of Public Health and Human Sciences
Office: 214 Milam Hall
Email Address: email@example.com
Mailing/Express Delivery Address:
Emily Ho, Ph.D.
College of Public Health and Human Sciences
214 Milam Hall
Corvallis, OR 97331-5103
My research interests are in the area of antioxidants and gene expression and dietary chemoprevention strategies. I am currently interested in understanding the role of the antioxidant nutrients such as zinc in maintaining DNA integrity and cancer development. Specifically, I am concerned with the effects of zinc status on DNA damage, DNA repair and stress-response signal pathways. We are also becoming interested in the effects of zinc on the immune system, especially as we age. A large proportion of thepopulation does not eat enough zinc, especially the elderly, and hence may be at increased risk for cancer and other disorders.
Another major focus in the lab is dietary approaches for prostate cancer prevention. We are investigating the molecular mechanisms by which foods such as soy, tea, and cruciferous vegetables may protect against prostate cancer.
||Postdoctoral Fellow, Nutrition, University of California, Berkeley and Children's Hospital Oakland Research Institute
||Ph.D., Human Nutrition, The Ohio State University
||B.S., Nutritional Sciences, University of Guelph, Guelph, ON, Canada
||Endowed Director, Moore Family Center for Whole Grain Foods, Nutrition and Preventive Health
||Associate Professor, School of Biological and Population Health Sciences, Oregon State University
||Principal Investigator, Linus Pauling Institute, Oregon State University
||Clinical Assistant Professor, Department of Medicine, Endocrinology & Clinical Nutrition, Oregon Health & Science University, Portland, OR
||Assistant Professor, Nutrition and Exercise Sciences, Oregon State University
||Affiliate Scientist, Linus Pauling Institute, Oregon State University
||Graduate Research and Teaching Associate, The Ohio State University, Columbus, OH
Awards and Honors
||Phi Kappa Phi- Emerging Scholar Award, Linus Pauling Institute
||Finalist-ILSI-Future Leader Award
||Junior Faculty Travel Award- American Urological Association
||Junior Investigator Award- FASEB Summer Trace Element Conference
||Best Paper Award in EBM journal 2001- Society for Experimental Biology and Medicine
||Postdoctoral Fellow-Training Grant NIH 5 T32 ES07075 'Studies of Environmental Mutagens and Carcinogens'
||Young Investigator Award, Outstanding Scientific Presentation, The Oxygen Society
||Society of Experimental Biology and Medicine Travel Award
||Young Investigator Award, Oxygen Club of California
||Graduate Research Forum, winner (oral presentation); The Ohio State University
||OARDC Graduate Research Award, Ohio Agriculture Research and Development Center
||Sigma Xi Student Research Award
||Young Investigator Award; The Oxygen Society
Professional Activities and Memberships
|MBG-2-Grant review panel, Department of Defense Prostate Cancer Research Program, 2008
|Editorial Board Member, Journal of Nutritional Biochemistry
|Member, Phi Kappa Phi Society
|Member, Society for Free Radical Biology and Medicine
|Member, American Association for Cancer Research
|Member, American Society for Nutrition
Conley MN, Wong CP, Duyck KM, Hord N, Ho E, Sharpton TJ. (2016). Aging and serum MCP-1 are associated with gut microbiome composition in a murine model. PeerJ 4:e1854.
Abbas A, Hall JA, Patterson WL 3rd, Ho E, Hsu A, Al-Mulla F, Georgel PT. (2016). Sulforaphane modulates telomerase activity via epigenetic regulation in prostate cancer cell lines. Biochem Cell Biol 94(1):71-81.
Watson GW, Wickramasekara S, Fang Y, Maier CS, Williams DE, Dashwood RH, Perez VI, Ho E. (2016). HDAC6 activity is not required for basal autophagic flux in metastatic prostate cancer cells. Exp Biol Med (Maywood) 241(11):1177-85.
Thomson CA, Ho E, Strom MB. (2016). Chemopreventive properties of 3,3'-diindolylmethane in breast cancer: evidence from experimental and human studies. Nutr Rev 74(7):432-43.
Madeen EP, Löhr CV, You H, Siddens LK, Krueger SK, Dashwood RH, Gonzalez FJ, Baird WM, Ho E, Bramer L, Waters KM, Williams DE. (2016). Dibenzo[def,p]chrysene transplacental carcinogenesis in wild-type, Cyp1b1 knockout, and CYP1B1 humanized mice. Mol Carcinog. [Epub ahead of print].
Watson GW, Wickramasekara SMaier CS, Williams DE, Dashwood RH, Ho E. (2015). Analysis of autophagic flux in response to sulforaphane in metastatic prostate cancer cells. Mol Nutr Food Res 59(10):1954-61.
Watson GW, Wickramasekara S, Fang, Y. Maier CS, Williams DE, Dashwood RH, Perez, VI, Ho E. (2015). Application of online RP/RP 2D LC-MS/MS method for the global proteomic profiling of prostate cancer cells. EuPA Open Proteom 9:34-40.
Atwell LL, Beaver LM, Shannon J, Williams DE, Dashwood RH, Ho E. (2015). Epigenetic Regulation by Sulforaphane: Opportunities for Breast and Prostate Cancer Chemoprevention. Curr Pharmacol Rep 1(2):102-111.
Atwell LL, Zhang Z, Mori M, Farris PE, Vetto JT, Naik AM, Oh KY, Thuillier P, Ho E, Shannon J. (2015). Sulforaphane Bioavailability and Chemopreventive Activity in Women Scheduled for Breast Biopsy. Cancer Prev Res (Phila) 8(12):1184-9.
Rajendran P, Dashwood WM, Li L, Kang Y, Kim E, Johnson G, Fischer KA, Löhr CV, Williams DE, Ho E, Yamamoto M, Lieberman DA, Dashwood RH. (2015). Nrf2 status affects tumor growth, HDAC3 gene promoter associations, and the response to sulforaphane in the colon. Clin Epigenetics 7(1):102.
Huang L, Drake VJ, Ho E. (2015) Zinc. Adv Nutr 6:224-226.
Wong CP, Rinaldi NA, Ho E. (2015) Zinc deficiency enhanced inflammatory response by increasing immune cell activation and inducing IL6 promoter demethylation. Mol Nutr Food Res, Epub ahead of print.
Atwell LL, Hsu A, Wong CP, Stevens JF, Bella D, Yu TW, Pereira CB, Löhr CV, Christensen JM, Dashwood RH, Williams DE, Shannon J, Ho E. (2015) Absorption and chemopreventive targets of sulforaphane in humans following consumption of broccoli sprouts or a myrosinase-treated broccoli sprout extract. Mol Nutr Food Res 59:424-433.
Beaver LM, Buchanan A, Sokolowski El, Riscoe AN, Wong CP, Chang JH, Löhr CV, Williams DE, Dashwood RH, Ho E. (2014) Transcriptome analysis reveals a dynamic and differential transcriptional response to sulforaphane in normal and prostate cancer cells and suggests a role for Sp1 in chemoprevention. Mol Nutr Food Res 58:2001-2013.
Wong CP, Hsu A, Buchanan A, Palomera-Sanchez Z, Beaver LM, Houseman EA, Williams DE, Dashwood RH, Ho E. (2014) Effects of sulforaphane and 3,3'-diindolylmethane on genome-wide promoter methylation in normal prostate epithelial cells and prostate cancer cells. PLoS One 9:e86787.
Kaur P, Shorey LE, Ho E, Dashwood RH, Williams DE. (2013) The epigenome as a potential mediator of cancer and disease prevention in prenatal development. Nutr Rev 71:441-457.
Watson GW, Beaver LM, Williams DE, Dashwood RH, Ho E. (2013) Phytochemicals from cruciferous vegetables, epigenetics, and prostate cancer prevention. AAPS J 15:951-961
Rajendran P, Kidane AI, Yu TW, Dashwood WM, Bisson WH, Löhr CV, Ho E, Williams DE, Dashwood RH. (2013) HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates. Epigenetics 8:612-623.
Shorey LE, Madeen EP, Atwell LL, Ho E, Löhr CV, Pereira CB, Dashwood RH, Williams DE. (2013) Differential modulation of dibenzo[def,p]chrysene transplacental carcinogenesis: maternal diets rich in indole-3-carbinol versus sulforaphane. Toxicol Appl Pharmacol 270:60-69.
Grider A, Wickwire K, Ho E, Chung CS, King J. (2013) Dietary zinc depletion and repletion affects plasma proteins: an analysis of the plasma proteome. Biometals 26:133-140.
Meyer M, Kesic MJ, Clarke J, Ho E, Simmen RC, Diaz-Sanchez D, Noah TL, Jaspers I. (2013) Sulforaphane induces SLPI secretion in the nasal mucosa. Respir Med 107:472-475.
Liuzzi JP, Wong CP, Ho E, Tracey A. (2013) Regulation of hepatic suppressor of cytokine signaling 3 by zinc. J Nutr Biochem 24:1028-1033.
Parasramka MA, Dashwood WM, Wang R, Saeed HH, Williams DE, Ho E, Dashwood RH. (2012) A role for low-abundance miRNAs in colon cancer: the miR-206/Krüppel-like factor 4 (KLF4) axis. Clin Epigenetics 4:16.
Wong CP, Magnusson KR, Ho E. (2013) Increased inflammatory response in aged mice is associated with age-related zinc deficiency and zinc transporter dysregulation. J Nutr Biochem 24:353-359.
Wang R, Löhr CV, Fischer K, Dashwood WM, Greenwood JA, Ho E, Williams DE, Ashktorab H, Dashwood MR, Dashwood RH. (2013) Epigenetic inactivation of endothelin-2 and endothelin-3 in colon cancer. Int J Cancer 132:1004-1012.
Beaver LM, Yu TW, Sokolowski EI, Williams DE, Dashwood RH, Ho E. (2012) 3,3'-Diindolylmethane, but not indole-3-carbinol, inhibits histone deacetylase activity in prostate cancer cells. Toxicol Appl Pharmacol 263:345-351.
Parasramka MA, Dashwood WM, Wang R, Abdelli A, Bailey GS, Williams DE, Ho E, Dashwood RH. (2012) MicroRNA profiling of carcinogen-induced rat colon tumors and the influence of dietary spinach. Mol Nutr Food Res 56:1259-1269.
Shorey LE, Hagman AM, Williams DE, Ho E, Dashwood RH, Benninghoff AD. (2012) 3,3'-Diindolylmethane induces G1 arrest and apoptosis in human acute T-cell lymphoblastic leukemia cells. PLoS One 7:e34975.
Wong CP, Ho E. (2012) Zinc and its role in age-related inflammation and immune dysfunction. Mol Nutr Food Res 56:77-87.