New Pilot Project Awards

The LPI Pilot Project program was initiated in 1997 to fund innovative research aligned with the Institute's mission. Experimental results from preliminary work can then be used to enhance the probability of federal grant funding. Three pilot project awards of $20,000 each were made early in 2001. 

Dr. Gayle Orner, LPI research associate in Dr. Rod Dashwood's lab, will investigate the combined chemoprotective effects of tea and sulindac, a nonsteroidal anti-inflammatory drug (NSAID), against colon cancer in mice. Tea may allow smaller doses of sulindac to be equally effective, while diminishing its side effects.

Dr. Andrew Buermeyer, an assistant professor in OSU's Department of Environmental and Molecular Toxicology, will conduct research on the possible increased susceptibility to colon cancer in animals with a deficiency in specific DNA repair mechanisms and exposed to cooked-meat mutagens.

Dr. Anitra Carr, former LPI research associate and assistant professor (senior research), has studied the role of reactive chemicals (oxidants) released by activated leukocytes in response to infection. The generation of oxidants is mediated by an enzyme called myeloperoxidase (MPO). The oxidants impair leukocyte function, which may contribute to the development of atherosclerotic lesions. Dr. Carr has investigated the role of antioxidants like vitamin C and lipoic acid in inhibiting the damaging effects of MPO-generated oxidants. 

Last updated November, 2001


Honoring a Scientific Giant with Nutritional Research Toward Longer, Better Lives


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