A Comprehensive List of All LPI Scientific Papers
Published in 2002 and 2003

2001 Addendum

SANTANA-RIOS G, ORNER GA, XU M, IZQUIERDO-PULIDO M, and DASHWOOD RH. Inhibition by white tea of 2-amino-1-methyl-6-pheny- limidazo[4,5-b]pyridine-induced colonic aberrant crypts in the F344 rat. Nutr. Cancer 41: 98-103, 2001.


AMANTANA A, SANTANA-RIOS G, BUTLER JA, XU M, WHANGER PD, and DASHWOOD RH. Antimutagenic activity of selenium-enriched green tea toward the heterocyclic amine 2-amino-3-methylimidazo [4,5-f]quinoline. Biol. Trace Elem. Res. 86: 177-191, 2002.

BECKMAN JS, ESTEVEZ AG, BARBEITO L, and CROW JP. CCS knockout mice establish an alternative source of copper for SOD in ALS. Free Radic. Biol. Med. 33: 1433-1435, 2002.

BECKMAN JS. Nitric oxide, peroxynitrite, and ageing. In: Critical Reviews of Oxidative Stress and Aging, (Cutler RG and Rodriguez H, eds), vol. 1, pp. 54-83, 2002.

CARR AC and FREI B. Human neutrophils oxidize low-density lipoprotein by a hypochlorous acid-dependent mechanism: the role of vitamin C. Biol. Chem. 383: 627-636, 2002.

CARR AC and FREI B. Vitamin C and cardiovascular diseases. In: Handbook of Antioxidants (Cadenas E and Packer L, eds), pp. 147-165, Academic Press, 2002.

CASSINA P, PELUFFO H, PEHAR M, MARTINEZ-PALMA L, RESSIA A, BECKMAN JS, ESTEVEZ AG, and BARBEITO L. Peroxynitrite triggers a phenotypic transformation in spinal cord astrocytes that induces motor neuron apoptosis. J. Neurosci. Res. 67: 21-29, 2002.

DASHWOOD W-M, ORNER GA, and DASHWOOD RH. Inhibition of beta-catenin/Tcf activity by white tea, green tea, and epigallocatechin-3-gallate (EGCG): minor contribution of H2O2 at physiologically relevant EGCG concentrations. Biochem. Biophys. Res. Commun. 296: 584-588, 2002.

DASHWOOD RH. Modulation of heterocyclic amine-induced mutagenicity and carcinogenicity: an ‘A-to-Z’ guide to chemopreventive agents, promoters, and transgenic models. Mutat. Res. 511: 89-112, 2002.

DASHWOOD RH. White tea—a new cancer inhibitor. Foods & Food Ingredients Journal of Japan 200: 19-26, 2002.

DEEN WM, TANNENBAUM SR, and BECKMAN JS. Protein tyrosine nitration and peroxynitrite. FASEB J. 16: 1144, 2002.

DIETRICH M, BLOCK G, HUDES M, MORROW JD, NORKUS EP, TRABER MG, CROSS CE, and PACKER L. Antioxidant supplementation decreases lipid peroxidation biomarker F(2)-isoprostanes in plasma of smokers. Cancer Epidemiol. Biomarkers Prevent. 11: 7-13, 2002.

ESTÉVEZ AG, KAMAID A, THOMPSON JA, CORNWELL TL, RADI R, BARBEITO L, and BECKMAN JS. Cyclic guanosine 5’ monophosphate (GMP) prevents expression of neuronal nitric oxide synthase and apoptosis in motor neurons deprived of trophic factors in rats. Neurosci. Lett. 326: 201-205, 2002.

FANG JC, KINLAY S, BELTRAME J, HIKITI H, WAINSTEIN M, BEHRENDT D, SUH J, FREI B, MUDGE GH, SELWYN AP, and GANZ P. Effect of vitamins C and E on progression of transplant-associated arteriosclerosis: a randomised trial. Lancet 359: 1108-1113, 2002.

FRANKE AA, CUSTER LJ, COONEY RV, TANAKA Y, XU M, and DASHWOOD RH. Inhibition of colonic aberrant crypt formation by the dietary flavonoids (+)-catechin and hesperidin. Adv. Exp. Med. Biol. 505: 123-133, 2002.

GALARIS D, ZHU B-Z, and FREI B. On the role of iron and copper ions in hydrogen peroxide-induced cellular DNA damage. Free Radic. Biol. Med. 32: 198-199, 2002.

HAGEN TM, LIU J, LYKKESFELDT J, WEHR CM, INGERSOLL RT, VINARSKY V, BARTHOLOMEW JC, and AMES BN. Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress. Proc. Natl. Acad. Sci. USA 99: 1870-1875, 2002.

HAGEN TM, MOREAU R, SUH JH, and VISIOLI F. Mitochondrial decay in the aging rat heart: evidence for improvement by dietary supplementation with acetyl-L-carnitine and/or lipoic acid. Ann. N.Y. Acad. Sci. 959: 491-507, 2002.

HEAD E, LIU J, HAGEN TM, MUGGENBURG BA, MILGRAM NW, AMES BN and COTMAN CW. Oxidative damage increases with age in a canine model of human brain aging. J. Neurochem. 82: 375-381, 2002.

HIGDON JV and FREI B. Vitamin C: an introduction. In: The Antioxidant Vitamins C and E (Packer L, Traber MG, Kraemer K, and Frei B, eds) pp. 1-16, AOCS Press, Champaign, IL, 2002.

KRUEGER SK, MARTIN SR, YUEH M-F, PEREIRA CB, and WILLIAMS DE. Identification of active flavin-containing monooxygenase isoform 2 in human lung and characterization of expressed protein. Drug Metab. Dispos. 30: 34-41, 2002.

KRUEGER SK, WILLIAMS DE, YUEH M-F, MARTIN SR, HINES RN, RAUCY JL, DOLPHIN CT, SHEPHARD EA, and PHILLIPS IR. Genetic polymorphisms of flavin-containing monooxygenase (FMO). Drug Metab. Rev. 34: 523-532, 2002.

LARSEN-SU SA, KRUEGER SK, YUEH M-F, PEREIRA CB, and WILLIAMS DE. Developmental regulation of flavin-containing monooxygenase form 1 in the liver and kidney of fetal and neonatal rabbits. Biochem. Pharmacol. 63: 1353-1359, 2002.

LATTARD V, LONGIN-SAUVAGEON C, KRUEGER SK, WILLIAMS DE, and BENOIT E. The FMO2 gene of laboratory rats, as in most humans, encodes a truncated protein. Biochem. Biophys. Res. Commun. 292: 558-563, 2002.

LAURIDSEN C, ENGEL H, JENSEN SK, CRAIG AM, and TRABER MG. Lactating sows and suckling piglets preferentially incorporate RRR- over all-rac-alpha-tocopherol into milk, plasma and tissues. J. Nutr. 132: 1258-1264, 2002.

LAURIDSEN C, ENGEL H, CRAIG AM, and TRABER MG. Relative bioactivity of dietary RRR- and all-rac-alpha-tocopheryl acetates in swine assessed with deuterium-labeled vitamin E. J. Anim. Sci. 80: 702-707, 2002.

LEONARD SW, TERASAWA Y, FARESE RV Jr, and TRABER MG. Incorporation of deuterated RRR- or all-rac-alpha-tocopherol in plasma and tissues of alpha-tocopherol transfer protein-null mice. Am. J. Clin. Nutr. 75: 555-560, 2002.

LI Q, DIXON BM, AL-FAGEEH M, BLUM CA, and DASHWOOD RH. Sequencing of the rat beta-catenin gene (Ctnnb1) and mutational analysis of liver tumors induced by 2-amino-3-methylimidazo[4,5-f]quinoline. Gene 283: 255-262, 2002.

LIU J, HEAD E, GHARIB AM, YUAN W, INGERSOLL RT, HAGEN TM, COTMAN CW, and AMES BN. Memory loss in old rats is associated with brain mito-chondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha-lipoic acid. Proc. Natl. Acad. Sci. USA 99: 2356-2361, 2002.

MONTINE KS, MONTINE TJ, MORROW JD, FREI B, MILATOVIC D, ECKENSTEIN F, and QUINN JF. Mouse cerebral prostaglandins, but not oxidative damage, change with age and are responsive to indomethacin treatment. Brain Res. 930: 75-82, 2002.

MOREAU R, ZHANG W, and HAGEN TM. Cellular effects of lipoic acid and its role in aging. In: Handbook of Antioxidants (Cadenas E and Packer L, eds) pp. 99-108, Marcel Dekker, Inc., New York, 2002.

MOYER RA, HUMMER KE, FINN CE, FREI B, and WROLSTAD RE. Anthocyanins, phenolics, and antioxidant capacity in diverse small fruits: Vaccinium, Rubus, and Ribes. J. Agric. Food Chem. 50: 519-525, 2002.

MYZAK MC and CARR AC. Myeloperoxidase-dependent caspase-3 activation and apoptosis in HL-60 cells: protection by the antioxidants ascorbate and (dihydro)lipoic acid. Redox Rep. 7: 47-53, 2002.

NARDINI M, FINKELSTEIN EI, REDDY S, VALACCHI G, TRABER M, CROSS CE, and VAN DER VLIET A. Acrolein-induced cytotoxicity in cultured human bronchial epithelial cells. Modulation by alpha-tocopherol and ascorbic acid. Toxicology 170: 173-185, 2002.

ORNER GA, DASHWOOD W-M, BLUM CA, DÍAZ GD, LI Q, AL-FAGEEH M, TEBBUTT N, HEATH JK, ERNST M, and DASHWOOD RH. Response of Apcmin and A33DNb-cat mutant mice to treatment with tea, sulindac, and 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (PhIP). Mutat. Res. 506-507: 121-127, 2002.

ORNER GA, DASHWOOD W-M, LI Q, AL-FAGEEH M, TEBBUTT N, HEATH JK, ERNST M, and DASHWOOD RH. Cellular effects of tea antioxidants in vitro and in mouse models of colorectal cancer: modulation of Wnt signaling. Free Radic. Res. 36: 16-20, 2002.

PACKER L, TRABER MG, KRAEMER K, and FREI B, eds. The Antioxidant Vitamins C and E, AOCS Press, Champaign, IL, 2002.

SCHRAMM L, LA M, HEIDBREDER E, HECKER M, BECKMAN JS, LOPAU K, ZIMMERMANN J, RENDL J, REINERS C, WINDERL S, WANNER C, and SCHMIDT HH. L-arginine deficiency and supplementation in experimental acute renal failure and in human kidney transplantation. Kidney Int. 61: 1423-1432, 2002.

SIMON RP and BECKMAN JS. Why pus is bad for the brain. Neurology 58: 167-168, 2002.

SMITH AR, VISIOLI F, and HAGEN TM. Vitamin C matters: increased oxidative stress in cultured human aortic endothelial cells without supplemental ascorbic acid. FASEB J. 16: 1102-1104, 2002.

STINTZING FC, STINTZING AS, CARLE R, FREI B, and WROLSTAD RE. Color and antioxidant properties of cyanidin-based anthocyanin pigments. J. Agric. Food Chem. 50: 6172-6181, 2002.

TENG R-J, YE Y-Z, PARKS DA, and BECKMAN JS. Urate produced during hypoxia protects heart proteins from peroxynitrite-mediated protein nitration. Free Radic. Biol. Med. 33: 1243-1249, 2002.

THORGAARD GH, BAILEY GS, WILLIAMS D, BUHLER DR, KAATTARI SL, RISTOW SS, HANSEN JD, WINTON JR, BARTHOLOMEW JL, NAGLER JJ, WALSH PJ, VIJAYAN MM, DEVLIN RH, HARDY RW, OVERTURF KE, YOUNG WP, ROBISON BD, REXROAD C, and PALTI Y. Status and opportunities for genomics research with rainbow trout. Comp. Biochem. Physiol. B. 133: 609-646, 2002.

TRABER MG. Reply to JG Bieri. Am. J. Clin. Nutr. 75: 781-782, 2002.

TRABER MG. Vitamin E bioavailability, biokinetics, and metabolism. In Handbook of Antioxidants (Cadenas E, and Packer L, eds) pp. 99-108, Marcel Dekker, Inc., New York, 2002.

TRABER MG and BLATT D. Vitamin E: evidence for the 2:1 preference for RRR- compared with all rac-alpha-tocopherols. In The Antioxidant Vitamins C and E (Packer L, Traber MG, Kraemer K, and Frei B, eds) pp. 161-170, AOCS Press, Champaign, IL, 2002.

VISIOLI F, SMITH A, ZHANG W, KEANEY JF Jr, HAGEN T, and FREI B. Lipoic acid and vitamin C potentiate nitric oxide synthesis in human aortic endothelial cells independently of cellular glutathione status. Redox Rep. 7: 223-227, 2002.

ZHANG W-J and FREI B. Albumin selectively inhibits TNFalpha-induced expression of vascular cell adhesion molecule-1 in human aortic endothelial cells. Cardiovasc. Res. 55: 820-829, 2002.

ZHANG W-J, STOCKER R, MCCALL MR, FORTE TM, and FREI B. Lack of inhibitory effect of HDL on TNFalpha-induced adhesion molecule expression in human aortic endothelial cells. Atherosclerosis 165: 241-249, 2002.

ZHU B-Z and FREI B. Biochemical and physiological interactions of vitamin C and iron: pro- or antioxidant? In The Antioxidant Vitamins C and E (Packer L, Traber MG, Kraemer K, and Frei B, eds), pp. 32-49, AOCS Press, Champaign, IL, 2002.

ZHU B-Z, ANTHOLINE WE, and FREI B. Thiourea protects against copper-induced oxidative damage by formation of a redox-inactive thiourea-copper complex. Free Radic. Biol. Med. 32: 1333-1338, 2002.

ZHU B-Z, ZHAO H-T, KALYANARAMAN B, and FREI B. Metal-independent production of hydroxyl radicals by halogenated quinones and hydrogen peroxide: an ESR spin trapping study. Free Radic. Biol. Med. 32: 465-473, 2002.

ZHU B-Z, CARR AC, and FREI B. Pyrrolidine dithiocarbamate is a potent antioxidant against hypochlorous acid-induced protein damage. FEBS Lett. 532: 80-84, 2002.

ZICKER SC, HAGEN TM, JOISHER N, GOLDER C, JOSHI DK, and MILLER EP. Safety of long-term feeding of dl-alpha-lipoic acid and its effect on reduced glutathione: oxidized glutathione ratios in beagles. Veterinary Therapeutics 3: 167-176, 2002.

2003 (January-September)

AUBORN KJ, FAN S, ROSEN EM, GOODWIN L, CHANDRASKAREN A, WILLIAMS DE, CHEN D, and CARTER TH. Indole-3-carbinol is a negative regulator of estrogen. J. Nutr. 133: 2470S-2475S, 2003.

BLUM CA, TANAKA T, ZHONG X, LI Q, DASHWOOD W-M, PEREIRA C, XU M, and DASHWOOD RH. Mutational analysis of Ctnnb1 and Apc in tumors from rats given 1,2-dimethylhydrazine or 2-amino-3-methylimidazo[4,5-f]quinoline: mutational “hotspots” and the relative expression of beta-catenin and c-Jun. Mol. Carcinog. 36: 195-203, 2003.

BLUM CA, XU M, ORNER GA, DÍAZ GD, LI Q, DASHWOOD W-M, BAILEY GS, and DASHWOOD RH. Promotion versus suppression of rat colon carcinogenesis by chlorophyllin and chlorophyll: modulation of apoptosis, cell proliferation, and beta-catenin/Tcf signaling. Mutat. Res. 523-524: 217-223, 2003.

CASHMAN JR, CAMP K, FAKHARZADEH SS, FENNESSEY PV, HINES RN, MAMER OA, MITCHELL SC, NGUYEN GP, SCHLENK D, SMITH RL, TJOA SS, WILLIAMS DE, and YANNICELLI S. Biochemical and clinical aspects of the human flavin-containing monooxygenase form 3 (FMO3) related to trimethylaminuria. Curr. Drug Metab. 4: 151-170, 2003.

DASHWOOD RH and XU M. The disposition and metabolism of 2-amino-3-methylimidazo[4,5-f]quinoline in the F344 rat at high versus low doses of indole-3-carbinol. Food Chem. Toxicol. 41: 1185-1192, 2003.

DASHWOOD RH. Use of transgenic and mutant animal models in the study of heterocyclic amine-induced mutagenesis and carcinogenesis. J. Biochem. Mol. Biol. 36: 35-42, 2003.

DEVARAJ S and TRABER MG. Gamma-Tocopherol, the new vitamin E? Am. J. Clin. Nut. 77: 530-531, 2003.

DÍAZ GD, LI Q, and DASHWOOD RH. Caspase-8 and apoptosis-inducing factor mediate a cytochrome c-independent pathway of apoptosis in human colon cancer cells induced by the dietary phytochemical chlorophyllin. Cancer Res. 63:
1254-1261, 2003.

DIETRICH M, BLOCK G, NORKUS EP, HUDES M, TRABER MG, CROSS CE, and PACKER L. Smoking and exposure to environmental tobacco smoke decrease some plasma antioxidants and increase gamma-tocopherol in vivo after adjustment for dietary antioxidant intakes. Am. J. Clin. Nutr. 77: 160-166, 2003.

FERRARO B, GALLI F, FREI B, KINGDON E, CANESTRARI F, RICE-EVANS C, BUONCRISTIANI U, DAVENPORT A, and MOORE KP. Peroxynitrite-induced oxidation of plasma lipids is enhanced in stable hemodialysis patients. Kidney Int. 63: 2207-2213, 2003.

FREI B. To C or not to C, That is the question! J. Am. Coll. Cardiol. 42: 253-255, 2003.

HIGDON JV and FREI B. Obesity and oxidative stress: a direct link to CVD? Arterioscler. Thromb. Vasc. Biol. 23: 365-367, 2003.

HIGDON JV and FREI B. Tea catechins and polyphenols: health effects, metabolism, and antioxidant functions. Crit. Rev. Food Sci. Nutr. 43: 89-143, 2003.

ISCHIROPOULOS H and BECKMAN JS. Oxidative stress and nitration in neurodegeneration: cause, effect, or association? J. Clin. Invest. 111: 163-169, 2003.

KAEMPF-ROTZOLL DE, TRABER MG, and ARAI H. Vitamin E and transfer proteins. Curr. Opin. Lipidol. 14, 249-254, 2003.

LEIBELT DA, HEDSTROM OR, FISCHER KA, PEREIRA CB, and WILLIAMS DE. Evaluation of chronic dietary exposure to indole-3-carbinol and absorption-enhanced 3,3’-diindolylmethane in Sprague-Dawley rats. Toxicol. Sci. 74: 10-21, 2003.

MICHELS AJ, JOISHER N, and HAGEN TM. Age-related decline of sodium-dependent ascorbic acid transport in isolated rat hepatocytes. Arch. Biochem. Biophys. 410: 112-120, 2003.

ORNER GA, DASHWOOD W-M, BLUM CA, DÍAZ GD, LI Q, and DASHWOOD RH. Suppression of tumorigenesis in the Apcmin mouse: down-regulation of beta-catenin signaling by a combination of tea plus sulindac. Carcinogenesis 24: 263-267, 2003.

SUH J, ZHU B-Z, and FREI B. Ascorbate does not act as a pro-oxidant towards lipids and proteins in human plasma exposed to redox-active transition metal ions and hydrogen peroxide. Free Radic. Biol. Med. 34: 1306-1314, 2003.

WILLIAMS DE, BAILEY GS, REDDY A, HENDRICKS JD, OGANESIAN A, ORNER GA, PEREIRA CB, and SWENBERG JA. The rainbow trout (Oncorhynchus mykiss) tumor model: recent applications in low-dose exposures to tumor initiators and promoters. Toxicol. Pathol. 31(Suppl): 58-61, 2003.

ZHANG W-J and FREI B. A different view on human albumin—authors’ reply. Cardiovasc. Res. 58: 723-724, 2003.

ZHANG W-J and FREI B. Intracellular metal ion chelators inhibit TNFalpha-induced SP-1 activation and adhesion molecule expression in human aortic endothelial cells. Free Radic. Biol. Med. 34: 674-682, 2003.

Last updated November, 2003

Micronutrient Research for Optimum Health

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