As announced in
the previous Newsletter; LPI has implemented a program to fund innovative
pilot projects related to the Institute's mission. After an external peer
review of several applications in July, OSU Professor Philip Whanger's
project to evaluate the anticancer effect of selenium-enriched ramps (also
known as wild leeks) was selected for funding for one year.
|This study represents
a collaboration between Dr. Whanger and colleagues at the Roswell
Park Cancer Institute, the State University of New York at Albany,
and Virginia Polytechnic Institute and State University. Selenium-enriched
ramps or regular ramps will be given to rats, which will be treated
with a carcinogen to induce tumors whose incidence will be measured.
Other experiments will determine whether excessive amounts of selenium
accumulate in tissues and will characterize the selenium compounds
present in the enriched ramps. The results will contribute to our
understanding of the anticancer role of selenium and its metabolism
(see Phil Whanger's article in this issue).
Ramps, or wild leeks
Dr. Anthony Vella, an OSU/LPI affiliate investigator and an assistant
professor in OSU's department of microbiology, has initiated a project
in allergy and autoimmunity, thanks to support from LPI. The project
is designed to elucidate some aspects of the molecular mechanism of
the immune response to environmental allergens.
His research will focus on a particularly pivotal molecule, interleukin-4
(IL-4), involved in the immune response and how it may be influenced
by micronutrients and other natural substances. Another objective
of this project is to illuminate the role of IL-4 in chronic autoimmune
disorders, such as arthritis and multiple sclerosis.
Last updated November, 1997
Tony Vella, Ph.D.
Honoring a Scientific
Giant with Research Toward Longer, Better Lives
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