Principal Investigator, Linus Pauling Institute
Associate Professor, Department of Animal Sciences
Office: 373 Linus Pauling Science Center
Email Address: email@example.com
Mailing/Express Delivery Address:
Gerd Bobe, Ph.D.
Linus Pauling Institute
Oregon State University
307 Linus Pauling Science Center
Corvallis, OR 97331
This laboratory focuses on identifying biomarkers in humans and parallel animal models that are associated with colorectal and pancreatic cancer and can be modified by diet and dietary supplements, including micronutrients and polyphenols. Colorectal cancer is an important public health problem annually leading worldwide to over 0.5 million deaths and in the U.S. nearly 150,000 new cases and 50,000 deaths. Dietary change, both feasible and safe, represents a viable strategy for preventing colorectal cancer; however, dietary intervention trials often showed no protection. There is a need for biomarkers of exposure, risk, and response/efficacy to dietary interventions. Such biomarkers will provide crucial data to a) identify individuals at increased risk or early stages of colorectal carcinogenesis, b) measure compliance with dietary interventions, and c) predict individuals most likely to benefit from a long-term dietary intervention (i.e., personalized cancer prevention).
In collaborations with researchers at the National Cancer Institute, Pennsylvania State University, Ohio State University, Texas A&M University, and Tufts, we have been using prospective NCI-funded human cohort and nutrition studies and link them to USDA and Tufts food data bases to identify diets and dietary components with promise of efficacious cancer prevention, most notable flavonols. For dietary components showing efficacy, we have been identifying biomarkers of exposure, risk, and early dietary response through parallel human intervention and animal model studies in serum, feces, and tissue, most notable interleukin 6. The functional significance of the identified molecular targets in carcinogenesis will be tested using cell culture and transgenic mouse studies. The goal is to use the identified molecular targets and biomarkers in clinical trials to test the efficacy of diets and dietary supplements for cancer prevention.
|1997||M.S., Nutritional Physiology and Animal Breeding, Minor in Statistics, Iowa State University|
|2002||Ph.D., Animal Nutrition, Minor in Statistics, Iowa State University|
|2006||M.P.H., Public Health Nutrition, Johns Hopkins Bloomberg School of Public Health|
|1992-2002||Graduate Research or Teaching Assistant, Departments of Animal Science, Biology, Biochemistry, Iowa State University, Ames, IA|
|2003-2005||Visiting Research Associate, Department of Food Science and Human Nutrition, National Food Safety and Toxicology Center, Michigan State University, East Lansing, MI|
|2005-2009||Cancer Prevention Fellow, Office of Preventive Oncology, Laboratory of Cancer Prevention, National Cancer Institute, Bethesda, MD|
|2009||Cancer Research Training Award Fellow, Laboratory of Cancer Prevention, National Cancer Institute, Frederick, MD|
|2009-present||Assistant Professor, Department of Animal Sciences; Principal Investigator, Linus Pauling Institute; Adjunct Faculty, Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR|
|2004||Recipient of the Richard M. Hoyt Award for Graduate Student Research from the National Milk Producers Fed.|
|2005/2009||Recipient of the Cancer Research Training Award from the NCI's Cancer Prevention Fellowship Program|
|2006||Member of Delta Omega, Honorary Society for Public Health|
|2007/2009||Recipient of the Aflac Scholar-in-Training Award from American Association for Cancer Research (AACR)|
|2008||Recipient of the Cancer Prevention Training Merit Award from NCI|
American Association for Cancer Research
American Dairy Science Association
American Society of Animal Science
American Society of Nutritional Science
American Society of Preventive Oncology
Institute of Food Technologists
Society for Experimental Biology and Medicine
Society for Nutrition Education and Behavior
Identification of molecular targets and predictive biomarkers for dietary colon cancer prevention, NIH Office of Cancer Complimentary and Alternative Medicine.
How do dietary flavonoids protect against advanced colorectal adenoma recurrence? A molecular epidemiologic study in the Polyp Prevention Trial (PPT), NIH Office of Dietary Supplements.
Kirkwood JS, Miranda CL, Bobe G, Maier CS, Stevens JF. (2016) 18O-Tracer metabolomics reveals protein turnover and CDP-choline cycle activity in differentiating 3T3-L1 pre-adipocytes. PLoS One 11:e0157118.
Mah E, Sapper TN, Chitchumroonchokchai C, Failla ML, Schill KE, Clinton SK, Bobe G, Traber MG, Bruno RS. (2015) α-Tocopherol bioavailability is lower in adults with metabolic syndrome regardless of dairy fat co-ingestion: a randomized, double-blind, crossover trial. Am J Clin Nutr 102:1070-1080.
Traber MG, Leonard SW, Bobe G, Fu X, Saltzman E, Grusak MA, Booth SL (2015) α-Tocopherol disappearance rates from plasma depend on lipid concentrations: studies using deuterium-labeled collard greens in younger and older adults. Am J Clin Nutr 101:752-759.
Watts EJ, Shen Y, Lansky EP, Nevo E, Bobe G, Traber MG. (2015) High environmental stress yields greater tocotrienol content while changing vitamin E profiles of wild emmer wheat seeds. J Med Food 18:216-223.
Hall JA, Bobe G, Vorachek WR, Kasper K, Traber MG, Mosher WD, Pirelli GJ, Gamroth M. (2014) Effect of supranutritional organic selenium supplementation on postpartum blood micronutrients, antioxidants, metabolites, and inflammation biomarkers in selenium-replete dairy cows. Biol Trace Elem Res 161:272-287.
Legette L, Karnpracha C, Reed RL, Choi J, Bobe G, Christensen JM, Rodriguez-Proteau R, Purnell JQ, Stevens JF. (2014) Human pharmacokinetics of xanthohumol, an antihyperglycemic flavonoid from hops. Mol Nutr Food Res 58:248-255.
Depner CM, Traber MG, Bobe G, Kensicki E, Bohren KM, Milne G, Jump DB. (2013) A metabolomic analysis of omega-3 fatty acid-mediated attenuation of western diet-induced nonalcoholic steatohepatitis in LDLR-/- mice. PLoS One8:e83756.
Saud SM, Young MR, Jones-Hall YL, Ileva L, Evbuomwan MO, Wise J, Colburn NH, Kim YS, Bobe G. (2013) Chemopreventive activity of plant flavonoid isorhamnetin in colorectal cancer is mediated by oncogenic Src and ß-catenin. Cancer Res73:5473-5484.
Moustafa ME, Carlson BA, Anver MR, Bobe G, Zhong N, Ward JM, Perella CM, Hoffmann VJ, Rogers K, Combs GF Jr, Schweizer U, Merlino G, Gladyshev VN, Hatfield DL. (2013) Selenium and selenoprotein deficiencies induce widespread pyogranuloma formation in mice, while high levels of dietary selenium decrease liver tumor size driven by TGFα. PLoS One 8:e57389.
Arem H, Bobe G, Sampson J, Subar AF, Park Y, Risch H, Hollenbeck A, Mayne ST, Stolzenberg-Solomon RZ. (2013) Flavonoid intake and risk of pancreatic cancer in the National Institutes of Health-AARP Diet and Health Study Cohort. Br J Cancer 10:1168-1172.
Mentor-Marcel RA, Bobe G, Sardo C, Wang LS, Kuo CT, Stoner G, Colburn NH. (2012) Plasma cytokines as potential response indicators to dietary freeze-dried black raspberries in colorectal cancer patients. Nutr Cancer 64:820-825.
Bobe G, Murphy G, Albert PS, Sansbury LB, Lanza E, Schatzkin A, Cross AJ. (2012) Dietary lignan and proanthocyanidin consumption and colorectal adenoma recurrence in the Polyp Prevention Trial. Int J Cancer 130:1649-1659.