Photo of Richard van BreemenPrincipal Investigator and Director, Linus Pauling Institute 
Professor of Medicinal Chemistry, Department of Pharmaceutical Sciences, College of Pharmacy

Richard van Breemen, Ph.D.
Director, Linus Pauling Institute
Office: 305 Linus Pauling Science Center
Telephone: 541-737-5078
Fax: 541-737-5077
Email Address: richard.vanbreemen@oregonstate.edu

Mailing/Express Delivery Address:
Richard van Breemen, Ph.D.
Linus Pauling Institute
Oregon State University
307 Linus Pauling Science Center
Corvallis, OR 97331

Research Interests

Cancer prevention by dietary antioxidants, and prostate cancer prevention by the carotenoid lycopene. Mass spectrometry-based pharmacological screening of natural products and combinatorial libraries for drug discovery, and high throughput screening to asses drug metabolism, toxicity and bioavailibility.

 

Education

1985 Ph.D. Johns Hopkins University
1980 B.A. Oberlin College

Professional Experience

2018-present Director, Linus Pauling Institute 
2018-present Linus Pauling Endowed Professor of Pharmaceutical Sciences, College of Pharmacy, OSU
2014-2017 Matthias C. Lu Collegiate Professor of Pharmacy, University of Illinois at Chicago
2011-2017 Director, UIC/NIH Center for Botanical Dietary Supplements Research, University of Illinois at Chicago
2000-2017 Professor of Medicinal Chemistry and Pharmacognosy College of Pharmacy, University of Illinois at Chicago
2014-present Visiting Professor, Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan, China
2010-2017 Director, Mass Spectrometry, Metabolomics and Proteomics Facility, University of Illinois Cancer Center, Chicago
2016-present Editorial Board, Journal of AOAC International
2013-present Regional Editor, Biomedical Chromatography
2010-present Editorial Board, Assay and Drug Development Technologies
2001-2006 Academic Liaison, Mass Spectrometry, Metabolomics and Proteomics Facility, Research Resources Center, University of Illinois at Chicago
2010-2012 Assistant Head for Curricular Affairs, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago
2006-2013 Editorial Board, Biomedical Chromatography
2010-present Editorial Board, Assay and Drug Development Technologies
1997-2010 Editor-in-Chief, Combinatorial Chemistry & High Throughput Screening
1994-2000 Associate Professor of Medicinal Chemistry College of Pharmacy, University of Illinois at Chicago
1986-1993 Assistant Professor of Chemistry, Member of the Biotechnology Faculty Director of the Mass Spectrometry Laboratory for Biotechnology Research North Carolina State University, Raleigh
1985-1986 Postdoctoral Fellow. Middle Atlantic Mass Spectrometry Laboratory, NSF Regional Instrumentation Facility, Johns Hopkins University School of Medicine, Baltimore, MD. (Laboratory of Catherine Fenselau and Robert Cotter) Visiting Assistant Professor of Chemistry North Carolina State University, Raleigh
1980-1985 Predoctoral research, Dept. of Pharmacology Johns Hopkins University School of Medicine. Baltimore, MD. Dissertation: "Electrophilic Reactions of 1-O-Acyl Glucuronides." (Advisor, Catherine Fenselau)
1979-1980 Honors research, Department of Chemistry, Oberlin College Oberlin, OH. Synthesis of spirocyclic lactones as analogs of insect pheromones
1979 Research assistant, Department of Pharmacology, Toxicology Center, Univ. of Iowa, Iowa City, IA. Quantitation of metabolites of diphenylhydantoin in human serum using GC/MS. (Laboratory of L.J. Fischer)

Awards and Honors

1980-1984 NIH Predoctoral Fellowship
 

 

1990 Award for Outstanding Paper at the Third North American Meeting of the International Society for the Study of Xenobiotics. San Diego, CA
1995 Named by the Editors of Spectroscopy as one of 19 “Bright Young Stars” in analytical spectroscopy.
1996 Invited speaker, 11th International Carotenoid Conference, Leiden, The Netherlands
2001 Invited speaker, International Convention on Pharmaceutical Sciences Commemorating the 50th Anniversary of the Pharmaceutical Society of Korea. Seoul, Korea
1997 Outstanding Paper Award, 88th American Oil Chemists Society Annual Meeting & Expo. Seattle, WA
2006 Linus Pauling Institute Seminar Series Speaker. OSU
2003-2006 University Scholar Award. University of Illinois
2009-2011 AOAC Presidential Task Force on Dietary Supplements
2008 AOAC International Harvey W. Wiley Award
2008 Journal of Chromatography B Top Referee
2010 AOAC International Outstanding Dietary Supplement Methods Panel Chair
2013 Invited speaker, Charles E. Dohme Memorial Symposium, Johns Hopkins University School of Medicine.
2015 Researcher of the Year, University of Illinois at Chicago
2017 Fellow of the International Carotenoid Society
2017 Varro E. Tyler Prize, American Society of Pharmacognosy,

Professional Activities and Memberships

President

Phytochemical Society of North America (2013-2014)

Member

Phi Lambda Upsilon (Chemistry Honor Society)

 

Editor

 

Recent Publications 

  • Kondratyuk TP, Adrian JA, Wright BJ, Park EJ, van Breemen RB, Morris KR, Pezzuto JM. "Evidence supporting the conceptual framework of cancer chemoprevention in canines.". Scientific reports. 2016;6:26500. doi:10.1038/srep26500.
  • Hauck ZZ, Feinstein DL, van Breemen RB. "LC-MS-MS Analysis of Brodifacoum Isomers in Rat Tissue.". Journal of analytical toxicology. 2016;40(4):304-9. doi:10.1093/jat/bkw008.
  • Zhou Q, Chen T, Zhang W, Bozkanat M, Li Y, Xiao L, van Breemen RB, Christman JW, Sznajder JI, Zhou G. "Suppression of von Hippel-Lindau Protein in Fibroblasts Protects against Bleomycin-Induced Pulmonary Fibrosis.". American journal of respiratory cell and molecular biology. 2016;54(5):728-39. doi:10.1165/rcmb.2015-0111OC.
  • Stahlhut RW, van Breemen RB, Gerona RR, Taylor JA, Welshons WV, Vom Saal FS. "Comment on "Optimal Exposure Biomarkers for Nonpersistent Chemicals in Environmental Epidemiology".". Environmental health perspectives. 2016;124(4):A66. doi:10.1289/ehp.1511057.
  • Imai A, Lankin DC, Nikolić D, Ahn S, van Breemen RB, Farnsworth NR, McAlpine JB, Chen S, Pauli GF. "Cycloartane Triterpenes from the Aerial Parts of Actaea racemosa.". Journal of natural products. 2016;79(3):541-54. doi:10.1021/acs.jnatprod.5b00927.
  • Kataria Y, Deaton RJ, Enk E, Jin M, Petrauskaite M, Dong L, Goldenberg JR, Cotler SJ, Jensen DM, van Breemen RB, Gann PH. "Retinoid and carotenoid status in serum and liver among patients at high-risk for liver cancer.". BMC gastroenterology. 2016;16:30. doi:10.1186/s12876-016-0432-5.
  • Newsome AG, Li Y, van Breemen RB. "Improved Quantification of Free and Ester-Bound Gallic Acid in Foods and Beverages by UHPLC-MS/MS.". Journal of agricultural and food chemistry. 2016;64(6):1326-34. doi:10.1021/acs.jafc.5b04966.
  • Hauck ZZ, Huang KG, Li G, van Breemen RB. "Determination of bisphenol A-glucuronide in human urine using ultrahigh-pressure liquid chromatography/tandem mass spectrometry.". Rapid communications in mass spectrometry : RCM. 2016;30(3):400-6. doi:10.1002/rcm.7450.