Principal Investigator and Director a.i., Linus Pauling Institute
Professor of Medicinal Chemistry, Department of Pharmaceutical Sciences, College of Pharmacy
Office: 435 Linus Pauling Science Center
Email Address: email@example.com
Mailing/Express Delivery Address:
Fred Stevens, Ph.D.
Linus Pauling Institute
Oregon State University
307 Linus Pauling Science Center
Corvallis, OR 97331
Research in the Stevens laboratory is aimed at determining the role and function of vitamins and dietary phytochemicals in human health and disease. Mass spectrometry-based metabolomics is a new direction in the laboratory for discovery of biological effects and mechanisms of actions.
Project 1: Xanthohumol and metabolic syndrome
Dr. Stevens and his associates have discovered that the hop natural product, xanthohumol, exerts anti-obesity and anti-hyperglycemic effects in animal models of metabolic syndrome. Current research on xanthohumol, now marketed as a dietary supplement and food additive, is focused on its fate in the human body and its effects on gene regulation relevant to lipid and glucose metabolism. Xanthohumol could earn a place in the early treatment of metabolic syndrome to prevent or retard the development of atherosclerosis and diabetes (Funding: NIH/NCCIH and Hopsteiner, Inc.).
Project 2: Vitamin C mitigates cardiovascular disease
Cardiovascular disease finds its origin in a chronic inflammatory state of the vasculature. Dr. Stevens and other investigators of the Linus Pauling Institute have shown that vitamin C supplementation reduces the formation of pro-inflammatory lipid peroxidation products in humans, which is significant because many large clinical trials have not been able to establish any effect of vitamin C on biomarkers of oxidative stress. The Stevens lab is also investigating the beneficial effects of vitamin C in the prevention of tolerance against nitrate therapy.
3) Brain stimulants from the medicinal herb, Centella asiatica, in the fight against Alzheimer’s disease (Funding: NIH/NCCIH).
4) Bioactives from the oilseed crop, meadowfoam (Limnanthes alba) (Funding: Natural Plant Products, Inc.).
||Postdoctoral Research Associate degree, Institute of Plant Biochemistry, Halle, Germany
||Postdoctoral Research Associate, Free University of Amsterdam
||Postdoctoral Research Associate, Oregon State University (OSU)
||Ph.D. University of Groningen, The Netherlands
||Pharmacy license, University of Groningen, The Netherlands
||M.Sc., University of Groningen, The Netherlands
||Director a.i., Linus Pauling Institute
||Professor of Medicinal Chemistry, Department of Pharmaceutical Sciences, OSU
||Associate Professor of Medicinal Chemistry, Department of Pharmaceutical Sciences, OSU
||Co-Director, Mass Spectrometry Core, Environmental and Health Sciences Center, OSU
||Principal Investigator, Linus Pauling Institute, OSU
||Assistant Professor of Medicinal Chemistry, Department of Pharmaceutical Sciences, OSU
||Assistant Professor (Sr. Res.), Department of Chemistry, OSU
||Staff Scientist/Group Leader, Institute of Plant Biochemistry, Halle a/d Saale, Germany
||Research Associate, Department of Bioorganic Chemistry, Free University of Amsterdam, The Netherlands
Awards and Honors
||Invited Speaker, 7th International Conference on Polyphenols and Health (ICPH 2015), Tours, France
Keynote Speaker, 2nd International Conference on Pharmacognosy, Phytochemistry, and Natural Products, Beijing, China
||Invited Speaker, 8th World Congress on Polyphenols Applications, Lisbon, Portugal
||Keynote Speaker, 3rd International Symposium on Vitamin C, Seoul, Korea
||Guest Professor (course on medicinal natural products), University of Antwerp, Belgium
||Teacher of the Year Award, Oregon State College of Pharmacy
||Beginning Grant-in-Aid Award, American Heart Association
||Ph.D. Cum Laude
||F.H.L Van Os Award, Society for Medicinal Plant Research (The Netherlands)
Professional Activities and Memberships
Phytochemical Society of North America (2013-2014)
Royal Pharmaceutical Society of the Netherlands (1990-present)
American Society of Mass Spectrometry (1996-present)
Phytochemical Society of North America (1997-present)
American Society of Pharmacognosy (2005-present)
American Heart Association (2004-present)
American Chemical Society (2008-present)
Reviewer for funding agencies
Netherlands Organization for Scientific Research (NWO, The Hague, 2005)
North Carolina Biotechnology Center (2007)
Bicentennial Program for Science and Technology, CONICYT (Reviewer and Site Visitor, Santiago, Chile, 2006-present)
National Institutes of Health (2009)
U.S. Department of Agriculture (2009)
Fonds Wetenschappelijk Onderzoek-Flanders, Belgium (2010-present)
Natural Sciences and Engineering Research Council of Canada (2010-2014)
Journal of Agricultural and Food Chemistry (1998-present)
Chemical Research in Toxicology (2004-9)
Journal of Mass Spectrometry (2004)
Planta Medica (2005)
Nature Chemical Biology (2005-9)
Cancer Letters (2006)
Free Radical Research (2006)
Antioxidants & Redox Signaling
Current Medicinal Chemistry
Free Radical Biology & Medicine
Journal of Applied Physiology
Molecular Nutrition and Food Research
Rapid Communications in Mass Spectrometry
Journal of Natural Products
Steroid Biochemistry & Molecular Biology
British Journal of Nutrition (2007)
Molecular Nutrition and Food Research (2005)
Recent Advances in Phytochemistry (2011-2014)
Phytochemistry Reviews (2015-present)
Complete list of publications: http://orcid.org/0000-0002-6348-9347
Stevens JF & Maier CS. (2016). The chemistry of gut microbial metabolism of polyphenols. Phytochem Rev 15: 425.
Miranda CL, Elias VD, Hay JJ, Choi J, Reed RL, Stevens JF. (2016). Xanthohumol improves dysfunctional glucose and lipid metabolism in diet-induced obese C57BL/6J mice. Arch Biochem Biophys 599:22-30.
Kirkwood JS, Miranda CL, Bobe G, Maier CS, Stevens JF. (2016). 18O-Tracer Metabolomics Reveals Protein Turnover and CDP-Choline Cycle Activity in Differentiating 3T3-L1 Pre-Adipocytes. PLoS One 11(6).
Wattanasiritham L, Theerakulkait C, Wickramasekara S, Maier CS, Stevens JF. (2016) Isolation and identification of antioxidant peptides from enzymatically hydrolyzed rice bran protein. Food Chem 192:156-162.
Elie MR, Choi J, Nkrumah-Elie YM, Gonnerman GD, Stevens JF, Tanguay RL. (2015) Metabolomic analysis to define and compare the effects of PAHs and oxygenated PAHs in developing zebrafish. Environ Res 140:502-510.
Choi J, Leonard SW, Kasper K, McDougall M, Stevens JF, Tanguay RL, Traber MG. (2015) Novel function of vitamin E in regulation of zebrafish (Danio rerio) brain lysophospholipids discovered using lipidomics. J Lipid Res 56:1182-1190.
Atwell LL, Hsu A, Wong CP, Stevens JF, Bella D, Yu TW, Pereira CB, Löhr CV, Christensen JM, Dashwood RH, Williams DE, Shannon J, Ho E. (2015) Absorption and chemopreventive targets of sulforaphane in humans following consumption of broccoli sprouts or a myrosinase-treated broccoli sprout extract. Mol Nutr Food Res 59:424-433.
Farley SM, Leonard SW, Stevens JF, Traber MG. (2014) Deuterium-labeled phylloquinone fed to α-tocopherol-injected rats demonstrates sensitivity of low phylloquinone-containing tissues to menaquinone-4 depletion. Mol Nutr Food Res 58:1610-1619.
Intanon S, Reed RL, Stevens JF, Hulting AG, Mallory-Smith CA. (2014) Identification and phytotoxicity of a new glucosinolate breakdown product from Meadowfoam (Limnanthes alba) seed meal. J Agric Food Chem 62:7423-7429.
Gray NE, Morré J, Kelley J, Maier CS, Stevens JF, Quinn JF, Soumyanath A. (2014) Caffeoylquinic acids in Centella asiatica protect against amyloid-ß toxicity. J Alzheimers Dis 40:359-373.
Lebold KM, Kirkwood JS, Taylor AW, Choi J, Barton CL, Miller GW, Du JL, Jump DB, Stevens JF, Tanguay RL, Traber MG. (2014) Novel liquid chromatography-mass spectrometry method shows that vitamin E deficiency depletes arachidonic and docosahexaenoic acids in zebrafish (Danio rerio) embryos. Redox Biol 172:105-113.
Humpf HU, Schneider C, Stevens JF. (2014) Functional food--where do we go? Mol Nutr Food Res 58:5-6.
Legette L, Karnpracha C, Reed RL, Choi J, Bobe G, Christensen JM, Rodriguez-Proteau R, Purnell JQ, Stevens JF. (2014) Human pharmacokinetics of xanthohumol, an antihyperglycemic flavonoid from hops. Mol Nutr Food Res 58:248-55.
Kirkwood JS, Legette LL, Miranda CL, Jiang Y, Stevens JF. (2013) A metabolomics-driven elucidation of the anti-obesity mechanisms of xanthohumol. J Biol Chem 288:19000-19013.
Kirkwood JS, Maier C, Stevens JF. (2013) Simultaneous, untargeted metabolic profiling of polar and nonpolar metabolites by LC-Q-TOF mass spectrometry. Curr Protoc Toxicol Chapter 4:Unit 4.39.
Wang Z, Kirkwood JS, Taylor AW, Stevens JF, Leid M, Ganguli-Indra G, Indra AK. (2013) Transcription factor Ctip2 controls epidermal lipid metabolism and regulates expression of genes involved in sphingolipid biosynthesis during skin development. J Invest Dermatol 133:668-676.
Legette LL, Luna AY, Reed RL, Miranda CL, Bobe G, Proteau RR, Stevens JF. (2013) Xanthohumol lowers body weight and fasting plasma glucose in obese male Zucker fa/fa rats. Phytochem 91:236-241.
Kirkwood JS, Lebold KM, Miranda CL, Wright CL, Miller GW, Tanguay RL, Barton CL, Traber MG, Stevens, JF. (2012) Vitamin C deficiency activates the purine nucleotide cycle in zebrafish. J Biol Chem 287:3833-3841
Zasada IA, Weiland JE, Reed RL, Stevens JF. (2012) Activity of meadowfoam (Limnanthes alba) seed meal glucolimnanthin degradation products against soilborne pathogens. J Agric Food Chem 60:339-345.
Legette L, Ma L, Reed RL, Miranda CL, Christensen JM, Proteau RR, Stevens JF. (2012) Pharmacokinetics of xanthohumol and metabolites in rats after oral and intravenous administration. Molec Nutr Food Res 56:466-474.