1. Insulin binds to and activates the
insulin receptor.
2. Insulin receptor activation stimulates the movement of chromium
into the cell.
3. Chromium binds to a peptide known as Apo-LMWCr* (Apo-LC).
4. Functional LMWCr (LC) binds to the insulin receptor and enhances
its activity.
*LMWCr = low-molecular weight chromium-binding substance
Adapted from Vincent, J.B. Quest for the molecular mechanism of chromium action and its relationship to diabetes. Nutr Rev. 2000; 58: 67-72.