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Micronutrient Information Center

A proposed model for the enhancing effects of chromium on insulin activity

1. Insulin binds to and activates the insulin receptor.
2. Insulin receptor activation stimulates the movement of chromium into the cell.
3. Chromium binds to a peptide known as Apo-LMWCr* (Apo-LC).
4. Functional LMWCr (LC) binds to the insulin receptor and enhances its activity.

*LMWCr = low-molecular weight chromium-binding substance

Adapted from Vincent, J.B. Quest for the molecular mechanism of chromium action and its relationship to diabetes. Nutr Rev. 2000; 58: 67-72.