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Micronutrient Information Center

Cell membrane fatty acids are used to make bioactive lipid mediators


The cell membrane serves as a pool of PUFA available for further metabolism to various bioactive lipids. Various environmental signals induce the enzyme phospholipase A2 to cleave fatty acids from the sn2 position of membrane phospholipids. Liberated fatty acids serve as substrates for the production of various bioactive lipid mediators (22). DGLA, dihomo-gamma-linolenic acid; AA, arachidonic acid; EPA, eicosapentaenoic acid; SPMs, specialized pro-resolving mediators.