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Micronutrient Information Center

Bioactive lipid mediators derived from omega-6 and omega-3 fatty acids


Dietary intake can alter the fatty acid composition of cell membranes and influence the local production of bioactive lipid mediators. Each PUFA precursor gives rise to a variety of molecules with a range of immune modulating activities: inflammatory (red and pink), anti-inflammatory (blue), and pro-resolving (green); isoprostanes (yellow) are markers of oxidative stress (16, 22, 25).