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Recent LPI Publications

Cancer Chemoprotection Program

Benninghoff AD, Bisson WH, Koch DC, Ehresman DJ, Kolluri SK, Williams DE. (2011) Estrogen-like activity of perfluoroalkyl acids in vivo and interaction with human and rainbow trout estrogen receptors in vitro. Toxicol Sci 120:42-58. PubMed

Bobe G, Murphy G, Albert PS, Sansbury LB, Young MR, Lanza E, Schatzkin A, Colburn NH, Cross AJ. (2011) Do interleukin polymorphisms play a role in the prevention of colorectal adenoma recurrence by dietary flavonols? Eur J Cancer Prev 20:86-95. PubMed

Hsu A, Bruno RS, Löhr CV, Taylor AW, Dashwood RH, Bray TM, Ho E. (2011) Dietary soy and tea mitigate chronic inflammation and prostate cancer via NFκB pathway in the Noble rat model. J Nutr Biochem 22:502-510. PubMed

May KC, Bobe G, Mueller CJ, Cannon MJ. (2011) Conjugated linoleic acid decreases prostaglandin synthesis in bovine luteal cells in vitro. Mol Reprod Dev 78:328-336. PubMed

Rajendran P, Delage B, Dashwood WM, Yu TW, Wuth B, Williams DE, Ho E, Dashwood RH. (2011) Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3/SMRT corepressor complex dissociation/reassembly. Mol Cancer 10:68. PubMed

Wang R, Dashwood RH. (2011) Endothelins and their receptors in cancer: Identification of therapeutic targets. Pharmacol Res 63:519-524. PubMed

Rajendran P, Williams DE, Ho E, Dashwood RH. (2011) Metabolism as a key to histone deacetylase inhibition. Crit Rev Biochem Mol Biol 46:181-199. PubMed

Clarke JD, Hsu A, Yu Z, Dashwood RH, Ho E. (2011) Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cells. Mol Nutr Food Res 55:999-1009. PubMed

Surh YJ, Dashwood RH, Na HK, Ji LL. (2011) Introduction to Nutrition and physical activity in aging, obesity, and cancer. Ann N Y Acad Sci 1229:vii-viii. PubMed

Wang R, Dashwood WM, Nian H, Löhr CV, Fischer KA, Tsuchiya N, Nakagama H, Ashktorab H, Dashwood RH. (2011) NADPH oxidase overexpression in human colon cancers and rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Int J Cancer 128:2581-2590. PubMed

Wang W, Jariyasopit N, Schrlau J, Jia Y, Tao S, Yu TW, Dashwood RH, Zhang W, Wang X, Simonich SL. (2011) Concentration and photochemistry of PAHs, NPAHs, and OPAHs and toxicity of PM2.5 during the Beijing Olympic Games. Environ Sci Technol 45:6887-6895. PubMed

Li Q, Luo C, Löhr CV, Dashwood RH. (2011) Activator protein-2α functions as a master regulator of multiple transcription factors in the mouse liver. Hepatol Res 41:776-783. PubMed

Hall JA, Sendek RL, Chinn RM, Bailey DP, Thonstad KN, Wang Y, Forsberg NE, Vorachek WR, Stang BV, Van Saun RJ, Bobe G. (2011) Higher whole-blood selenium is associated with improved immune responses in footrot-affected sheep. Vet Res 42:99. PubMed

Wong CP, Nguyen LP, Noh SK, Bray TM, Bruno RS, Ho E. (2011) Induction of regulatory T cells by green tea polyphenol EGCG. Immunol Lett 139:7-13. PubMed

Hasaniya NW, Premaratne S, Zhang WW, Razzuk A, Abdul-Ghani AA, Dashwood RH, Eklof B, Tinsley L, McNamara JJ. (2011) Amelioration of ischemia-reperfusion injury in an isolated rabbit lung model using OXANOH. Vasc Endovascular Surg 45:581-591. PubMed

Rajendran P, Ho E, Williams DE, Dashwood RH. (2011) Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells. Clin Epigenetics 3:4. PubMed

Clarke JD, Riedl K, Bella D, Schwartz SJ, Stevens JF, Ho E. (2011) Comparison of isothiocyanate metabolite levels and histone deacetylase activity in human subjects consuming broccoli sprouts or broccoli supplement. J Agric Food Chem 59:10955-10963. PubMed

Clarke JD, Hsu A, Riedl K, Bella D, Schwartz SJ, Stevens JF, Ho E. (2011) Bioavailability and inter-conversion of sulforaphane and erucin in human subjects consuming broccoli sprouts or broccoli supplement in a cross-over study design. Pharmacol Res 64:456-463. PubMed

Ho E, Beaver LM, Williams DE, Dashwood RH. (2011) Dietary factors and epigenetic regulation for prostate cancer prevention. Adv Nutr 2:497-510. PubMed

Clarke JD, Hsu A, Williams DE, Dashwood RH, Stevens JF, Yamamoto M, Ho E. (2011) Metabolism and tissue distribution of sulforaphane in Nrf2 knockout and wild-type mice. Pharm Res 28:3171-3179. PubMed

Hsu A, Wong CP, Yu Z, Williams DE, Dashwood RH, Ho E. (2011) Promoter de-methylation of cyclin D2 by sulforaphane in prostate cancer cells. Clin Epigenetics 3:3. PubMed

Crowell SR, Amin SG, Anderson KA, Krishnegowda G, Sharma AK, Soelberg JJ, Williams DE, Corley RA. (2011) Preliminary physiologically based pharmacokinetic models for benzo[a]pyrene and dibenzo[def,p]chrysene in rodents. Toxicol Appl Pharmacol 257:365-376. PubMed

Fieber LA, Tanguay RL, Walter RB, Williams DE. (2012) Aquatic animal models of human disease: selected papers from the 5th conference. Comp Biochem Physiol C Toxicol Pharmacol 155:9-10. PubMed

Williams DE. (2012) The rainbow trout liver cancer model: response to environmental chemicals and studies on promotion and chemoprevention. Comp Biochem Physiol C Toxicol Pharmacol 155:121-127. PubMed

Benninghoff AD, Orner GA, Buchner CH, Hendricks JD, Duffy AM, Williams DE. (2012) Promotion of hepatocarcinogenesis by perfluoroalkyl acids in rainbow trout. Toxicol Sci 125:69-78. PubMed

McQuistan TJ, Simonich MT, Pratt MM, Pereira CB, Hendricks JD, Dashwood RH, Williams DE, Bailey GS. (2012) Cancer chemoprevention by dietary chlorophylls: a 12,000-animal dose-dose matrix biomarker and tumor study. Food Chem Toxicol 50:341-352. PubMed

Hall JA, Van Saun RJ, Bobe G, Stewart WC, Vorachek WR, Mosher WD, Nichols T, Forsberg NE, Pirelli GJ. (2012) Organic and inorganic selenium: I. Oral bioavailability in ewes. J Anim Sci 90:568-576. PubMed

Stewart WC, Bobe G, Vorachek WR, Pirelli GJ, Mosher WD, Nichols T, Van Saun RJ, Forsberg NE, Hall JA. (2012) Organic and inorganic selenium: II. Transfer efficiency from ewes to lambs. J Anim Sci 90:577-584. PubMed

Parasramka MA, Ho E, Williams DE, Dashwood RH. (2012) MicroRNAs, diet, and cancer: new mechanistic insights on the epigenetic actions of phytochemicals. Mol Carcinog 51:213-230. PubMed

Bobe G, Murphy G, Albert PS, Sansbury LB, Lanza E, Schatzkin A, Cross AJ. (2012) Dietary lignan and proanthocyanidin consumption and colorectal adenoma recurrence in the Polyp Prevention Trial. Int J Cancer 130:1649-1659. PubMed

Shorey LE, Castro DJ, Baird WM, Siddens LK, Löhr CV, Matzke MM, Waters KM, Corley RA, Williams DE. (2012) Transplacental carcinogenesis with dibenzo[def,p]chrysene (DBC): timing of maternal exposures determines target tissue response in offspring. Cancer Lett 317:49-55. PubMed

Shorey LE, Hagman AM, Williams DE, Ho E, Dashwood RH, Benninghoff AD. (2012) 3,3'-Diindolylmethane induces G1 arrest and apoptosis in human acute T-cell lymphoblastic leukemia cells. PLoS One 7:e34975. PubMed

Lee SH, Richardson RL, Dashwood RH, Baek SJ. (2012) Capsaicin represses transcriptional activity of β-catenin in human colorectal cancer cells. J Nutr Biochem 23:646-655. PubMed

Stewart WC, Bobe G, Pirelli GJ, Mosher WD, Hall JA. (2012) Organic and inorganic selenium: III. Ewe and progeny performance. J Anim Sci 90:4536-4543. PubMed

Wang R, Löhr CV, Fischer K, Dashwood WM, Greenwood JA, Ho E, Williams DE, Ashktorab H, Dashwood MR, Dashwood RH. (2012) Epigenetic inactivation of endothelin-2 and endothelin-3 in colon cancer. Int J Cancer [Epub ahead of print]. PubMed

Mentor-Marcel RA, Bobe G, Sardo C, Wang LS, Kuo CT, Stoner G, Colburn NH. (2012) Plasma cytokines as potential response indicators to dietary freeze-dried black raspberries in colorectal cancer patients. Nutr Cancer 64:820-825. PubMed

Parasramka MA, Dashwood WM, Wang R, Abdelli A, Bailey GS, Williams DE, Ho E, Dashwood RH. (2012) MicroRNA profiling of carcinogen-induced rat colon tumors and the influence of dietary spinach. Mol Nutr Food Res 56:1259-1269. PubMed

Mentor-Marcel RA, Bobe G, Sardo C, Wang LS, Kuo CT, Stoner G, Colburn NH. (2012) Plasma cytokines as potential response indicators to dietary freeze-dried black raspberries in colorectal cancer patients. Nutr Cancer 64:820-825. PubMed

Siddens LK, Larkin A, Krueger SK, Bradfield CA, Waters KM, Tilton SC, Pereira CB, Löhr CV, Arlt VM, Phillips DH, Williams DE, Baird WM. (2012) Polycyclic aromatic hydrocarbons as skin carcinogens: Comparison of benzo[a]pyrene, dibenzo[def,p]chrysene and three environmental mixtures in the FVB/N mouse. Toxicol Appl Pharmacol 264:377-386. PubMed

Beaver LM, Yu TW, Sokolowski EI, Williams DE, Dashwood RH, Ho E. (2012) 3,3'-Diindolylmethane, but not indole-3-carbinol, inhibits histone deacetylase activity in prostate cancer cells. Toxicol Appl Pharmacol 263:345-351. PubMed

Cardiovascular and Metabolic Diseases

Zhu BZ, Mao L, Fan RM, Zhu JG, Zhang YN, Wang J, Kalyanaraman B, Frei B. (2011) Ergothioneine prevents copper-induced oxidative damage to DNA and protein by forming a redox-inactive ergothioneine-copper complex. Chem Res Toxicol 24:30-34. PubMed

Bowman GL, Shannon J, Ho E, Traber MG, Frei B, Oken BS, Kaye JA, Quinn JF. (2011) Reliability and validity of food frequency questionnaire and nutrient biomarkers in elders with and without mild cognitive impairment. Alzheimer Dis Assoc Disord 25:49-57. PubMed

Kuiper HC, Stevens JF. (2011) LC-MS/MS quantitation of mercapturic acid conjugates of lipid peroxidation products as markers of oxidative stress. Curr Protoc Toxicol, Chapter 17:Unit17.14.2. PubMed

Didenco S, Gillingham MB, Go MD, Leonard SW, Traber MG, McEvoy CT. (2011) Increased vitamin E intake is associated with higher alpha-tocopherol concentration in the maternal circulation but higher alpha-carboxyethyl hydroxychroman concentration in the fetal circulation. Am J Clin Nutr 93:368-373. PubMed

Jump DB, Torres-Gonzalez M, Olson LK. (2011) Soraphen A, an inhibitor of acetyl CoA carboxylase activity, interferes with fatty acid elongation. Biochem Pharmacol 81:649-660. PubMed

Jump DB. (2011) Fatty acid regulation of hepatic lipid metabolism. Curr Opin Clin Nutr Metab Care 14:115-120. Review. PubMed

Drake VJ, Frei B. (2011) Vitamin C in human disease prevention. In: Vitamins in the prevention of human diseases (Herrmann W, Obeid R, eds), pp. 347-362, Walter de Gruyter: Berlin.

Sousse LE, Yamamoto Y, Enkhbaatar P, Rehberg SW, Wells SM, Leonard S, Traber MG, Yu YM, Cox RA, Hawkins HK, Traber LD, Herndon DN, Traber DL. (2011) Acute lung injury-induced collagen deposition is associated with elevated asymmetric dimethylarginine and arginase activity. Shock 35:282-288. PubMed

Lebold KM, Grant KA, Freeman WM, Wiren KM, Miller GW, Kiley C, Leonard SW, Traber MG. (2011) Individual differences in hyperlipidemia and vitamin E status in response to chronic alcohol self-administration in cynomolgus monkeys. Alcohol Clin Exp Res 35:474-483. PubMed

Kuiper HC, Bruno RS, Traber MG, Stevens JF. (2011) Vitamin C supplementation lowers urinary levels of 4-hydroperoxy-2-nonenal metabolites in humans. Free Radic Biol Med 50:848-853. PubMed

Zhang WJ, Wei H, Tien YT, Frei B. (2011) Genetic ablation of phagocytic NADPH oxidase in mice limits TNFα-induced inflammation in the lungs but not other tissues. Free Radic Biol Med 50:1517-1525. PubMed

Lotito SB, Zhang WJ, Yang CS, Crozier A, Frei B. (2011) Metabolic conversion of dietary flavonoids alters their anti-inflammatory and antioxidant properties. Free Radic Biol Med 51:454-463. PubMed

Barker T, Martins TB, Hill HR, Kjeldsberg CR, Trawick RH, Leonard SW, Walker JA, Traber MG. (2011) Vitamins E and C modulate the association between reciprocally regulated cytokines after an anterior cruciate ligament injury and surgery. Am J Phys Med Rehabi 90:638-647. PubMed

Traber MG, Stevens JF. (2011) Vitamins C and E: beneficial effects from a mechanistic perspective. Free Radic Biol Med 51:1000-1013. PubMed

Wei H, Frei B, Beckman JS, Zhang WJ. (2011) Copper chelation by tetrathiomolybdate inhibits lipopolysaccharide-induced inflammatory responses in vivo. Am J Physiol Heart Circ Physiol 301(3):H712-H720. PubMed

Wu J, Stevens JF, Maier CS. (2011) Mass spectrometry-based quantification of myocardial protein adducts with acrolein in an in vivo model of oxidative stress. Mol Nutr Food Res 55:1401-1410. PubMed

Stevens JF, Maier CS. (2011) Acrolein. Mol Nutr Food Res 55:1275-1276. PubMed

Traber MG, Labut EM, Leonard SW, Lebold KM. (2011) α-Tocopherol injections in rats up-regulate hepatic ABC transporters, but not cytochrome P450 enzymes. Free Radic Biol Med 51:2031-2040. PubMed

Lebold KM, Jump DB, Miller GW, Wright CL, Labut EM, Barton CL, Tanguay RL, Traber MG. (2011) Vitamin E deficiency decreases long-chain PUFA in zebrafish (Danio rerio). J Nutr 141:2113-2118. PubMed

Gonzalez D, Mustacich DJ, Traber MG, Cherian G. (2011) Early feeding and dietary lipids affect broiler tissue fatty acids, vitamin E status, and cyclooxygenase-2 protein expression upon lipopolysaccharide challenge. Poult Sci 90:2790-2800. PubMed

Shen Y, Lebold K, Lansky EP, Traber MG, Nevo E. (2011) 'Tocol-omic' diversity in wild barley, short communication. Chem Biodivers 8:2322-2330. PubMed

Zasada IA, Weiland JE, Reed RL, Stevens JF. (2012) Activity of meadowfoam (Limnanthes alba) seed meal glucolimnanthin degradation products against soilborne pathogens. J Agric Food Chem 60:339-345. PubMed

Ho E, Dukovcic S, Hobson B, Wong CP, Miller G, Hardin K, Traber MG, Tanguay RL. (2012) Zinc transporter expression in zebrafish (Danio rerio) during development. Comp Biochem Physiol C Toxicol Pharmacol 155:26-32. PubMed

Bravo KS, Ramírez R, Durst R, Escobedo-Avellaneda ZJ, Welti-Chanes J, Sanz PD, Torres JA. (2012) Formation risk of toxic and other unwanted compounds in pressure-assisted thermally processed foods. J Food Sci 77:R1-R10. PubMed

Semba RD, Ang A, Talegawkar S, Crasto C, Dalal M, Jardack P, Traber MG, Ferrucci L, Arab L. (2012) Dietary intake associated with serum versus urinary carboxymethyl-lysine, a major advanced glycation end product, in adults: the Energetics Study. Eur J Clin Nutr 66:3-9. PubMed

Bowman GL, Silbert LC, Howieson D, Dodge HH, Traber MG, Frei B, Kaye JA, Shannon J, Quinn JF. (2012) Nutrient biomarker patterns, cognitive function, and MRI measures of brain aging. Neurology 78:241-249. PubMed

Kirkwood JS, Lebold KM, Miranda CL, Wright CL, Miller GW, Tanguay RL, Barton CL, Traber MG, Stevens JF. (2012) Vitamin C deficiency activates the purine nucleotide cycle in zebrafish. J Biol Chem 287:3833-3841. PubMed

Legette L, Ma L, Reed RL, Miranda CL, Christensen JM, Rodriguez-Proteau R, Stevens JF. (2012) Pharmacokinetics of xanthohumol and metabolites in rats after oral and intravenous administration. Mol Nutr Food Res 56:466-474. PubMed

Yamamoto Y, Enkhbaatar P, Sousse LE, Sakurai H, Rehberg SW, Asmussen S, Kraft ER, Wright CL, Bartha E, Cox RA, Hawkins HK, Traber LD, Traber MG, Szabo C, Herndon DN, Traber DL. (2012) Nebulization with γ-tocopherol ameliorates acute lung injury after burn and smoke inhalation in the ovine model. Shock 37:408-414. PubMed

Michels A, Frei B. (2012) Vitamin C. In: Biochemical, physiological, and molecular aspects of human nutrition, 3rd ed. (Stipanuk MH, Caudill MA, eds), pp. 626-654, Elsevier Saunders: St. Louis.

Traber MG, Manor D. (2012) Vitamin E. Adv Nutr 3:330-331. PubMed

Miller GW, Labut EM, Lebold KM, Floeter A, Tanguay RL, Traber MG. (2012) Zebrafish (Danio rerio) fed vitamin E-deficient diets produce embryos with increased morphologic abnormalities and mortality. J Nutr Biochem 23:478-486. PubMed

Legette LL, Moreno Luna AY, Reed RL, Miranda CL, Bobe G, Proteau RR, Stevens JF. (2012) Xanthohumol lowers body weight and fasting plasma glucose in obese male Zucker fa/fa rats. Phytochemistry. [Epub ahead of print]. PubMed

Farley SM, Leonard SW, Labut EM, Raines HF, Card DJ, Harrington DJ, Mustacich DJ, Traber MG. (2012) Vitamin E decreases extra-hepatic menaquinone-4 concentrations in rats fed menadione or phylloquinone. Mol Nutr Food Res 56:912-922. PubMed

Miranda CL, Maier CS, Stevens JF. (2012) Flavonoids. In: eLS. John Wiley & Sons, Ltd: Chichester.

Frei B, Birlouez-Aragon I, Lykkesfeldt J. (2012) Authors' perspective: what is the optimum intake of vitamin C in humans? Crit Rev Food Sci Nutr 52:815-829. PubMed

Wei H, Zhang WJ, McMillen TS, Leboeuf RC, Frei B. (2012) Copper chelation by tetrathiomolybdate inhibits vascular inflammation and atherosclerotic lesion development in apolipoprotein E-deficient mice. Atherosclerosis. 223:306-313. PubMed

Asleh R, Nakhoul FM, Miller-Lotan R, Awad H, Farbstein D, Levy NS, Nakhoul N, Iancu TC, Manov I, Laue M, Traber MG, Lebold KM, Levy AP. (2012) Poor lysosomal membrane integrity in proximal tubule cells of haptoglobin 2-2 genotype mice with diabetes mellitus. Free Radic Biol Med 53:779-786. PubMed

Depner CM, Torres-Gonzalez M, Tripathy S, Milne G, Jump DB. (2012) Menhaden oil decreases high-fat diet-induced markers of hepatic damage, steatosis, inflammation, and fibrosis in obese ldlr-/- mice. J Nutr 142:1495-1503. PubMed

Jump DB, Depner CM, Tripathy S. (2012) Omega-3 fatty acid supplementation and cardiovascular disease. J Lipid Res. 53:2525-2545. PubMed

Lebold KM, Ang A, Traber MG, Arab L. (2012) Urinary a-carboxyethyl hydroxychroman can be used as a predictor of α-tocopherol adequacy, as demonstrated in the Energetics Study. Am J Clin Nutr 96:801-809. PubMed

Yamamoto Y, Enkhbaatar P, Sakurai H, Rehberg S, Asmussen S, Ito H, Sousse LE, Cox RA, Deyo DJ, Traber LD, Traber MG, Herndon DN, Traber DL. (2012) Development of a long-term ovine model of cutaneous burn and smoke inhalation injury and the effects of early excision and skin autografting. Burns 38:908-916. PubMed

Yilmazer-Musa M, Griffith AM, Michels AJ, Schneider E, Frei B. (2012) Grape Seed and Tea Extracts and Catechin 3-Gallates Are Potent Inhibitors of α-Amylase and α-Glucosidase Activity. J Agric Food Chem 60:8924-8929. PubMed

Durst RW, Weaver GW. (2012) Nutritional content of fresh and canned peaches. J Sci Food Agric [Epub ahead of print]. PubMed

Jump DB, Depner CM, Tripathy S. (2012) Omega-3 fatty acid supplementation and cardiovascular disease. J Lipid Res [Epub ahead of print]. PubMed

Tripathy S and Jump DB. (2013) Elovl5 regulates the mTORC2-Akt-FOXO1 pathway by controlling hepatic cis-vaccenic acid synthesis in diet-induced obese mice. J Lipid Res 54:71-84. PubMed

Healthy Aging Program

Monette JS, Gómez LA, Moreau RF, Dunn KC, Butler JA, Finlay LA, Michels AJ, Shay KP, Smith EJ, Hagen TM. (2011) (R)-alpha-Lipoic acid treatment restores ceramide balance in aging rat cardiac mitochondria. Pharmacol Res 63:23-29. PubMed

Voinov VG, Deinzer ML, Beckman JS, Barofsky DF. (2011) Electron capture, collision-induced, and electron capture-collision induced dissociation in Q-TOF. J Am Soc Mass Spectrom 22:607-611. PubMed

Rhoads TW, Lopez NI, Zollinger DR, Morré JT, Arbogast BL, Maier CS, Denoyer L, Beckman JS. (2011) Measuring copper and zinc superoxide dismutase from spinal cord tissue using electrospray mass spectrometry. Anal Biochem 415:52-58. PubMed

Albright RK, Goska BJ, Hagen TM, Chi MY, Cauwenberghs G, Chiang PY. (2011) OLAM: A wearable, non-contact sensor for continuous heart-rate and activity monitoring. Conf Proc IEEE Eng Med Biol Soc 2011:5625-5628. PubMed

Visioli F, Hagen TM. (2011) Antioxidants to enhance fertility: role of eNOS and potential benefits. Pharmacol Res 64:431-437. PubMed

Trumbull KA, McAllister D, Gandelman MM, Fung WY, Lew T, Brennan L, Lopez N, Morré J, Kalyanaraman B, Beckman JS. (2012) Diapocynin and apocynin administration fails to significantly extend survival in G93A SOD1 ALS mice. Neurobiol Dis 45:137-144. PubMed

Gómez LA, Heath SH, Hagen TM. (2012) Acetyl-L-carnitine supplementation reverses the age-related decline in carnitine palmitoyltransferase 1 (CPT1) activity in interfibrillar mitochondria without changing the L-carnitine content in the rat heart. Mech Ageing Dev 133:99-106. PubMed

Finlay LA, Michels AJ, Butler JA, Smith EJ, Monette JS, Moreau RF, Petersen SK, Frei B, Hagen TM. (2012) R-a-lipoic acid does not reverse hepatic inflammation of aging, but lowers lipid anabolism, while accentuating circadian rhythm transcript profiles. Am J Physiol Regul Integr Comp Physiol 302:R587-597. PubMed

Sun G, Li H, Wu X, Covarrubias M, Scherer L, Meinking K, Luk B, Chomchan P, Alluin J, Gombart AF, Rossi JJ. (2012) Interplay between HIV-1 infection and host microRNAs. Nucleic Acids Res 40:2181-2196. PubMed

Shenvi SV, Smith E, Hagen TM. (2012) Identification of age-specific Nrf2 binding to a novel antioxidant response element locus in the Gclc promoter: a compensatory means for the loss of glutathione synthetic capacity in the aging rat liver? Aging Cell 11:297-304. PubMed

Drechsel DA, Estévez AG, Barbeito L, Beckman JS. (2012) Nitric oxide-mediated oxidative damage and the progressive demise of motor neurons in ALS. Neurotox Res 22:251-264. PubMed

Gómez LA, Hagen TM. (2012) Age-related decline in mitochondrial bioenergetics: Does supercomplex destabilization determine lower oxidative capacity and higher superoxide production? Semin Cell Dev Biol 23:758-767. PubMed

Fok WC, Zhang Y, Salmon AB, Bhattacharya A, Gunda R, Jones D, Ward W, Fisher K, Richardson A, Pérez VI. (2012) Short-term treatment with rapamycin and dietary restriction have overlapping and distinctive effects in young mice. J Gerontol A Biol Sci Med Sci 68:108-116. PubMed

Shay KP, Michels AJ, Kong AN, Hagen TM. (2012) Cap-independent Nrf2 translation is part of a lipoic acid-stimulated detoxification stress response. Biochim Biophys Acta 1823:1102-1109. PubMed

Campbell Y, Fantacone ML, Gombart AF. (2012) Regulation of antimicrobial peptide gene expression by nutrients and by-products of microbial metabolism. Eur J Nutr 51:899-907. PubMed

Guo C, Rosoha E, Lowry MB, Borregaard N, Gombart AF. (2012) Curcumin induces human cathelicidin antimicrobial peptide gene expression through a vitamin D receptor-independent pathway. J Nutr Biochem [Epub ahead of print]. PubMed

Kyme P, Thoennissen NH, Tseng CW, Thoennissen GB, Wolf AJ, Shimada K, Krug UO, Lee K, Müller-Tidow C, Berdel WE, Hardy WD, Gombart AF, Koeffler HP, Liu GY. (2012) C/EBPε mediates nicotinamide-enhanced clearance of Staphylococcus aureus in mice. J Clin Invest 122:3316-3329. PubMed

Keith DJ, Butler JA, Bemer B, Dixon B, Johnson S, Garrard M, Sudakin DL, Christensen JM, Pereira C, Hagen TM. (2012) Age and gender dependent bioavailability of R- and R,S-a-lipoic acid: A pilot study. Pharmacol Res 66:199-206. PubMed