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Recent LPI Publications

Cancer Chemoprotection Program

Clarke JD, Hsu A, Yu Z, Dashwood RH, Ho E. (2011) Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cells. Mol Nutr Food Res, Epub ahead of print. PubMed

Wang R, Dashwood RH. (2011) Endothelins and their receptors in cancer: Identification of therapeutic targets. Pharmacol Res, Epub ahead of print. PubMed

Wang R, Dashwood WM, Nian H, Löhr CV, Fischer KA, Tsuchiya N, Nakagama H, Ashktorab H, Dashwood RH. (2011) NADPH oxidase overexpression in human colon cancers and rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Int J Cancer 128:2581-2590. PubMed

Cardiovascular and Metabolic Diseases

Lotito SB, Zhang WJ, Yang CS, Crozier A, Frei B. (2011) Metabolic conversion of dietary flavonoids alters their anti-inflammatory and antioxidant properties. Free Radic Biol Med, Epub ahead of print. PubMed

Barker T, Martins TB, Hill HR, Kjeldsberg CR, Trawick RH, Leonard SW, Walker JA, Traber MG. (2011) Vitamins E and C modulate the association between reciprocally regulated cytokines after an anterior cruciate ligament injury and surgery. Am J Phys Med Rehabi, Epub ahead of print. PubMed

Zhu BZ, Mao L, Fan RM, Zhu JG, Zhang YN, Wang J, Kalyanaraman B, Frei B. (2011) Ergothioneine prevents copper-induced oxidative damage to DNA and protein by forming a redox-inactive ergothioneine-copper complex. Chem Res Toxicol 24:30-34. PubMed

Kuiper HC, Stevens JF. (2011) LC-MS/MS quantitation of mercapturic acid conjugates of lipid peroxidation products as markers of oxidative stress. Curr Protoc Toxicol, Chapter 17:Unit17.14.2. PubMed

Zhang WJ, Wei H, Tien YT, Frei B. (2011) Genetic ablation of phagocytic NADPH oxidase in mice limits TNFa-induced inflammation in the lungs but not other tissues. Free Radic Biol Med 50:1517-1525. PubMed

Kuiper HC, Bruno RS, Traber MG, Stevens JF. (2011) Vitamin C supplementation lowers urinary levels of 4-hydroperoxy-2-nonenal metabolites in humans. Free Radic Biol Med 50:848-853. PubMed

Didenco S, Gillingham MB, Go MD, Leonard SW, Traber MG, McEvoy CT. (2011) Increased vitamin E intake is associated with higher alpha-tocopherol concentration in the maternal circulation but higher alpha-carboxyethyl hydroxychroman concentration in the fetal circulation. Am J Clin Nutr 93:368-373. PubMed

Jump DB, Torres-Gonzalez M, Olson LK. (2011) Soraphen A, an inhibitor of acetyl CoA carboxylase activity, interferes with fatty acid elongation. Biochem Pharmacol 81:649-660. PubMed

Jump DB. (2011) Fatty acid regulation of hepatic lipid metabolism. Curr Opin Clin Nutr Metab Care 14:115-120. Review. PubMed

Healthy Aging Program

Rhoads TW, Lopez NI, Zollinger DR, Morré JT, Arbogast BL, Maier CS, Denoyer L, Beckman JS. (2011) Measuring copper and zinc superoxide dismutase from spinal cord tissue using electrospray mass spectrometry. Anal Biochem, Epub ahead of print. PubMed

Monette JS, Gómez LA, Moreau RF, Dunn KC, Butler JA, Finlay LA, Michels AJ, Shay KP, Smith EJ, Hagen TM. (2011) (R)-alpha-Lipoic acid treatment restores ceramide balance in aging rat cardiac mitochondria. Pharmacol Res 63:23-29. PubMed