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Recent LPI Publications

Cardiovascular and Metabolic Diseases

Frei B, Ames BN, Blumberg JB, Willett WC. (2014) Enough is enough. Ann Intern Med 160:807. Link

Durst RW, Weaver GW. (2013) Nutritional content of fresh and canned peaches. J Sci Food Agric 93:593-603. PubMed

Michels AJ, Hagen TM, Frei B. (2013) Human genetic variation influences vitamin C homeostasis by altering vitamin C transport and antioxidant enzyme function. Annu Rev Nutr 33:45-70. PubMed

Tripathy S, Jump DB. (2013) Elovl5 regulates the mTORC2-Akt-FOXO1 pathway by controlling hepatic cis-vaccenic acid synthesis in diet-induced obese mice. J Lipid Res 54:71-84. PubMed

Rodriguez KJ, Wong HK, Oddos T, Southall M, Frei B, Kaur S. (2013) A purified Feverfew extract protects from oxidative damage by inducing DNA repair in skin cells via a PI3-kinase-dependent Nrf2/ARE pathway. J Dermatol Sci 72:304-310. PubMed

Michels AJ, Frei B. (2013) Myths, artifacts, and fatal flaws: Identifying limitations and opportunities in vitamin C research. Nutrients 5:5161-5192. PubMed

Meyer KA, Sijtsma FP, Nettleton JA, Steffen LM, Van Horn L, Shikany JM, Gross MD, Mursu J, Traber MG, Jacobs DR Jr. (2013) Dietary patterns are associated with plasma F2-isoprostanes in an observational cohort study of adults. Free Radic Biol Med 57:201-209. PubMed

Traber MG. (2013) Mechanisms for the prevention of vitamin E excess. J Lipid Res 54:2295-2306. PubMed

Lebold KM, Löhr CV, Barton CL, Miller GW, Labut EM, Tanguay RL, Traber MG. (2013) Chronic vitamin E deficiency promotes vitamin C deficiency in zebrafish leading to degenerative myopathy and impaired swimming behavior. Comp Biochem Physiol C Toxicol Pharmacol 157:382-389. PubMed

Farley SM, Leonard SW, Taylor AW, Birringer M, Edson KZ, Rettie AE, Traber MG. (2013) ω-Hydroxylation of phylloquinone by CYP4F2 is not increased by α-tocopherol. Mol Nutr Food Res. 57:1785-1793. PubMed

Iwaniec UT, Turner RT, Smith BJ, Stoecker BJ, Rust A, Zhang B, Vasu VT, Gohil K, Cross CE, Traber MG. (2013) Evaluation of long-term vitamin E insufficiency or excess on bone mass, density, and microarchitecture in rodents. Free Radic Biol Med 65:1209-1214. PubMed

Mah E, Pei R, Guo Y, Ballard KD, Barker T, Rogers VE, Parker BA, Taylor AW, Traber MG, Volek JS, Bruno RS. (2013) γ-Tocopherol-rich supplementation additively improves vascular endothelial function during smoking cessation. Free Radic Biol Med 65:1291-1299. PubMed

Shen Y, Lansky E, Traber M, Nevo E. (2013) Increases in both acute and chronic temperature potentiate tocotrienol concentrations in wild barley at 'Evolution Canyon'. Chem Biodivers 10:1696-1705. PubMed

Murer SB, Aeberli I, Braegger CP, Gittermann M, Hersberger M, Leonard SW, Taylor AW, Traber MG, Zimmermann MB. (2013) Antioxidant supplements reduce oxidative stress and stabilize liver function tests but do not reduce inflammation in a randomized controlled trial in obese children and adolescents. Nutr 144:193-201. PubMed

Depner CM, Traber MG, Bobe G, Kensicki E, Bohren KM, Milne G, Jump DB. (2013) A metabolomic analysis of omega-3 fatty acid-mediated attenuation of western diet-induced nonalcoholic steatohepatitis in LDLR (-/-) mice. PLoS One. 8:e83756. PubMed

Wang Z, Kirkwood JS, Taylor AW, Stevens JF, Leid M, Ganguli-Indra G, Indra AK. (2013) Transcription factor Ctip2 controls epidermal lipid metabolism and regulates expression of genes involved in sphingolipid biosynthesis during skin development. J Invest Dermatol 133:668-676. PubMed

Kirkwood JS, Maier C, Stevens JF. (2013) Simultaneous, untargeted metabolic profiling of polar and nonpolar metabolites by LC-Q-TOF mass spectrometry. Curr Protoc Toxicol, Chapter 4:Unit4.39. PubMed

Kirkwood JS, Legette LL, Miranda CL, Jiang Y, Stevens JF. (2013) A metabolomics-driven elucidation of the anti-obesity mechanisms of xanthohumol. J Biol Chem 288:19000-19013. PubMed

Depner CM, Philbrick KA, Jump DB. (2013) Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis. J Nutr 143:315-323. PubMed

Jump DB, Tripathy S, Depner CM. (2013) Fatty acid-regulated transcription factors in the liver. Annu Rev Nutr 33:249-269. PubMed

Lebold KM, Kirkwood JS, Taylor AW, Choi J, Barton CL, Miller GW, Du JL, Jump DB, Stevens JF, Tanguay RL, Traber MG. (2013) Novel liquid chromatography-mass spectrometry method shows that vitamin E deficiency depletes arachidonic and docosahexaenoic acids in zebrafish (Danio rerio) embryos. Redox Biol. 2:105-113. PubMed

Michels AJ, Frei B. (2013) Myths, artifacts, and fatal flaws: Identifying limitations and opportunities in vitamin C research. Nutrients 5:5161-5192. PubMed

Legette L, Karnpracha C, Reed RL, Choi J, Bobe G, Christensen JM, Rodriguez-Proteau R, Purnell JQ, Stevens JF. (2014) Human pharmacokinetics of xanthohumol, an antihyperglycemic flavonoid from hops. Mol Nutr Food Res 58:248-255. PubMed

Lebold KM, Traber MG. (2014) Interactions between α-tocopherol, polyunsaturated fatty acids, and lipoxygenases during embryogenesis. Free Radic Biol Med 66:13-19. PubMed

Forman HJ, Traber M, Ursini F. (2014) Antioxidants: GRABbing new headlines. Free Radic Biol Med 66:1-2. PubMed

Wei H, Zhang WJ, LeBoeuf R, Frei B. (2014) Copper induces—and copper chelation by tetrathiomolybdate inhibits—endothelial activation in vitro. Redox Report 19:40-48. PubMed

Lykkesfeldt J, Michels AJ, Frei B. (2014) Vitamin C. Adv Nutr 5:16-8. PubMed

Warnock JJ, Spina J, Bobe G, Duesterdieck-Zellmer KF, Ott J, Baltzer WI, Bay BK. (2014) Culture of canine synoviocytes on porcine intestinal submucosa scaffolds as a strategy for meniscal tissue engineering for treatment of meniscal injury in dogs. Vet J 199:49-56. PubMed

Gray NE, Morré J, Kelley J, Maier CS, Stevens JF, Quinn JF, Soumyanath A. (2014) Caffeoylquinic acids in Centella asiatica protect against amyloid-β toxicity. J Alzheimers Dis [Epub ahead of print]. PubMed

Cancer Chemoprotection Program

Kaur P, Shorey LE, Ho E, Dashwood RH, Williams DE. (2013) The epigenome as a potential mediator of cancer and disease prevention in prenatal development. Nutr Rev 71:441-457. PubMed

Watson GW, Beaver LM, Williams DE, Dashwood RH, Ho E. (2013) Phytochemicals from cruciferous vegetables, epigenetics, and prostate cancer prevention. AAPS J 15:951-961. PubMed

Rajendran P, Kidane AI, Yu TW, Dashwood WM, Bisson WH, Löhr CV, Ho E, Williams DE, Dashwood RH. (2013) HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates. Epigenetics 8:612-623. PubMed

Shorey LE, Madeen EP, Atwell LL, Ho E, Löhr CV, Pereira CB, Dashwood RH, Williams DE. (2013) Differential modulation of dibenzo[def,p]chrysene transplacental carcinogenesis: maternal diets rich in indole-3-carbinol versus sulforaphane. Toxicol Appl Pharmacol 270:60-69. PubMed

Larkin A, Siddens LK, Krueger SK, Tilton SC, Waters KM, Williams DE, Baird WM. (2013) Application of a fuzzy neural network model in predicting polycyclic aromatic hydrocarbon-mediated perturbations of the Cyp1b1 transcriptional regulatory network in mouse skin. Toxicol Appl Pharmacol 267:192-199. PubMed

Depner CM, Traber MG, Bobe G, Kensicki E, Bohren KM, Milne G, Jump DB. (2013) A metabolomic analysis of omega-3 fatty acid-mediated attenuation of western diet-induced nonalcoholic steatohepatitis in LDLR (-/-) mice. PLoS One 8:e83756. PubMed

Hall JA, Vorachek WR, Stewart WC, Gorman ME, Mosher WD, Pirelli GJ, Bobe G. (2013) Selenium supplementation restores innate and humoral immune responses in footrot-affected sheep. PLoS One 8:e82572. PubMed

Hall JA, Bobe G, Vorachek WR, Hugejiletu, Gorman ME, Mosher WD, Pirelli GJ. (2013) Effects of feeding selenium-enriched alfalfa hay on immunity and health of weaned beef calves. Biol Trace Elem Res 156:96-110. PubMed

Warnock JJ, Duesterdieck-Zellmer KF, Bobe G, Baltzer WI, Ott J. (2013) Synoviocyte neotissues towards in vitro meniscal tissue engineering. Res Vet Sci 95:1201-1209. PubMed

Saud SM, Young MR, Jones-Hall YL, Ileva L, Evbuomwan MO, Wise J, Colburn NH, Kim YS, Bobe G. (2013) Chemopreventive activity of plant flavonoid isorhamnetin in colorectal cancer is mediated by oncogenic Src and ß-catenin. Cancer Res 73:5473-5484. PubMed

Hugejiletu H, Bobe G, Vorachek WR, Gorman ME, Mosher WD, Pirelli GJ, Hall JA. (2013) Selenium supplementation alters gene expression profiles associated with innate immunity in whole-blood neutrophils of sheep. Biol Trace Elem Res 154:28-44. PubMed

Vorachek WR, Hugejiletu, Bobe G, Hall JA. (2013) Reference gene selection for quantitative PCR studies in sheep neutrophils. Int J Mol Sci 14:11484-11495. PubMed

Hall JA, Bobe G, Hunter JK, Vorachek WR, Stewart WC, Vanegas JA, Estill CT, Mosher WD, Pirelli GJ. (2013) Effect of feeding selenium-fertilized alfalfa hay on performance of weaned beef calves. PLoS One 8:e58188. PubMed

Moustafa ME, Carlson BA, Anver MR, Bobe G, Zhong N, Ward JM, Perella CM, Hoffmann VJ, Rogers K, Combs GF Jr, Schweizer U, Merlino G, Gladyshev VN, Hatfield DL. (2013) Selenium and selenoprotein deficiencies induce widespread pyogranuloma formation in mice, while high levels of dietary selenium decrease liver tumor size driven by TGFa. PLoS One 8:e57389. PubMed

Legette LL, Luna AY, Reed RL, Miranda CL, Bobe G, Proteau RR, Stevens JF. (2013) Xanthohumol lowers body weight and fasting plasma glucose in obese male Zucker fa/fa rats. Phytochemistry 91:236-241. PubMed

Wong CP, Magnusson KR, Ho E. (2013) Increased inflammatory response in aged mice is associated with age-related zinc deficiency and zinc transporter dysregulation. J Nutr Biochem 24:353-359. PubMed

Liuzzi JP, Wong CP, Ho E, Tracey A. (2013) Regulation of hepatic suppressor of cytokine signaling 3 by zinc. J Nutr Biochem 24:1028-1033. PubMed

Meyer M, Kesic MJ, Clarke J, Ho E, Simmen RC, Diaz-Sanchez D, Noah TL, Jaspers I. (2013) Sulforaphane induces SLPI secretion in the nasal mucosa. Respir Med 107:472-475. PubMed

Grider A, Wickwire K, Ho E, Chung CS, King J. (2013) Dietary zinc depletion and repletion affects plasma proteins: an analysis of the plasma proteome. Biometals 26:133-140. PubMed

Siddens LK, Krueger SK, Henderson MC, Williams DE. (2014) Mammalian flavin-containing monooxygenase (FMO) as a source of hydrogen peroxide. Biochem Pharmacol [Epub ahead of print]. PubMed

Warnock JJ, Bobe G, Duesterdieck-Zellmer KF, Spina J, Ott J, Baltzer WI, Bay BK. (2014) Growth factor treated tensioned synoviocyte neotissues: Towards meniscal bioscaffold tissue engineering. Vet J [Epub ahead of print]. PubMed

Wong CP, Hsu A, Buchanan A, Palomera-Sanchez Z, Beaver LM, Houseman EA, Williams DE, Dashwood RH, Ho E. (2014) Effects of sulforaphane and 3,3'-diindolylmethane on genome-wide promoter methylation in normal prostate epithelial cells and prostate cancer cells. PLoS One 9:e86787. PubMed

Legette L, Karnpracha C, Reed RL, Choi J, Bobe G, Christensen JM, Rodriguez-Proteau R, Purnell JQ, Stevens JF. (201r) Human pharmacokinetics of xanthohumol, an antihyperglycemic flavonoid from hops. Mol Nutr Food Res 58:248-55. PubMed

Healthy Aging Program

Viera L, Radmilovich M, Vargas MR, Dennys CN, Wilson L, Barnes S, Franco MC, Beckman JS, Estévez AG. (2013) Temporal patterns of tyrosine nitration in embryo heart development. Free Radic Biol Med 55:101-108. PubMed

Rhoads TW, Williams JR, Lopez NI, Morré JT, Bradford CS, Beckman JS. (2013) Using theoretical protein isotopic distributions to parse small-mass-difference post-translational modifications via mass spectrometry. J Am Soc Mass Spectrom 24:115-124. PubMed

Franco MC, Ye Y, Refakis CA, Feldman JL, Stokes AL, Basso M, Melero Fernández de Mera RM, Sparrow NA, Calingasan NY, Kiaei M, Rhoads TW, Ma TC, Grumet M, Barnes S, Beal MF, Beckman JS, Mehl R, Estévez AG. (2013) Nitration of Hsp90 induces cell death. Proc Natl Acad Sci USA 110:E1102-E1111. PubMed

Bahadorani S, Mukai ST, Rabie J, Beckman JS, Phillips JP, Hilliker AJ. (2013) Expression of zinc-deficient human superoxide dismutase in Drosophila neurons produces a locomotor defect linked to mitochondrial dysfunction. Neurobiol Aging 34:2322-2330. PubMed

Gandelman M, Levy M, Cassina P, Barbeito L, Beckman JS. (2013) P2X7 receptor-induced death of motor neurons by a peroxynitrite/FAS-dependent pathway. J Neurochem 126:382-388. PubMed

Trias E, Díaz-Amarilla P, Olivera-Bravo S, Isasi E, Drechsel DA, Lopez N, Bradford CS, Ireton KE, Beckman JS, Barbeito L. (2013) Phenotypic transition of microglia into astrocyte-like cells associated with disease onset in a model of inherited ALS. Front Cell Neurosci 7:274. PubMed

Zamzow DR, Elias V, Shumaker M, Larson C, Magnusson KR. (2013) An increase in the association of GluN2B containing NMDA receptors with membrane scaffolding proteins was related to memory declines during aging. J Neurosci 33:12300-12305. PubMed

Fok WC, Bokov A, Gelfond J, Yu Z, Zhang Y, Doderer M, Chen Y, Javors M, Wood WH 3rd, Zhang Y, Becker KG, Richardson A, Pérez VI. (2013) Combined treatment of rapamycin and dietary restriction has a larger effect on the transcriptome and metabolome of liver. Aging Cell [Epub ahead of print]. PubMed

Triana-Martínez F, López-Diazguerrero NE, Maciel-Barón LA, Morales-Rosales SL, Galván-Arzate S, Fernandez-Perrino FJ, Zentella A, Pérez VI, Gomez-Quiroz LE, Königsberg M. (2013) Cell proliferation arrest and redox state status as part of different stages during senescence establishment in mouse fibroblasts. Biogerontology [Epub ahead of print]. PubMed

Fok WC, Chen Y, Bokov A, Zhang Y, Salmon AB, Diaz V, Javors M, Wood WH 3rd, Zhang Y, Becker KG, Pérez VI, Richardson A. (2014) Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome. PLoS One 9:e83988. PubMed

Lowry MB, Guo C, Borregaard N, Gombart AF. (2014) Regulation of the human cathelicidin antimicrobial peptide gene by 1α,25-dihydroxyvitamin D3 in primary immune cells. J Steroid Biochem Mol Biol [Epub ahead of print]. PubMed

Okamoto R, Gery S, Gombart AF, Wang X, Castellani LW, Akagi T, Chen S, Arditi M, Ho Q, Lusis AJ, Li Q, Koeffler HP. (2014) Deficiency of CCAAT/enhancer binding protein-epsilon reduces atherosclerotic lesions in LDLR-/- mice. PLoS One. 9:e85341. PubMed

Guo C, Sinnott B, Niu B, Lowry MB, Fantacone ML, Gombart AF. (2014) Synergistic induction of human cathelicidin antimicrobial peptide gene expression by vitamin D and stilbenoids. Mol Nutr Food Res 58:528-536. PubMed