Cardiometabolic Disease Prevention

Choi J, Leonard SW, Kasper K, McDougall M, Stevens JF, Tanguay RL, Traber MG. (2015) Novel function of vitamin E in regulation of zebrafish (Danio rerio) brain lysophospholipids discovered using lipidomics. J Lipid res 56:1182-1190. PubMed

Zhang WJ, Frei B. (2015) Astragaloside IV inhibits NF-κB activation and inflammatory gene expression in LPS-treated mice. Mediators Inflamm 2015:274314. PubMed

Elie MR, Choi J, Nkrumah-Elie YM, Gonnerman GD, Stevens JF, Tanguay RL. (2015) Metabolomic analysis to define and compare the effects of PAHs and oxygenated PAHs in developing zebrafish. Environ Res 140:502-510. PubMed

Jump DB, Depner CM, Tripathy S, Lytle KA. (2015) Impact of dietary fat on the development of non-alcoholic fatty liver disease in Ldlr-/- mice. Proc Nutr Soc 18:1-9. PubMed

Lytle KA, Depner CM, Wong CP, Jump DB. (2015) Docosahexaenoic acid attenuates Western diet-induced hepatic fibrosis in Ldlr-/- mice by targeting the TGFβ-Smad3 pathway. J Lipid Res 56:1936-1946. PubMed

Mah E, Sapper TN, Chitchumroonchokchai C, Failla ML, Schill KE, Clinton SK, Bobe G, Traber MG, Bruno RS. (2015) α-Tocopherol bioavailability is lower in adults with metabolic syndrome regardless of dairy fat co-ingestion: a randomized, double-blind, crossover trial. Am J Clin Nutr 102:1070-1080. PubMed

Jump DB, Depner CM, Tripathy S, Lytle KA. (2015) Potential for dietary ω-3 fatty acids to prevent nonalcoholic fatty liver disease and reduce the risk of primary liver cancer. Adv Nutr 6:694-702. PubMed

Kerr DC, Zava DT, Piper WT, Saturn SR, Frei B, Gombart AF. (2015) Associations between vitamin D levels and depressive symptoms in healthy young adult women. Psychiatry Res 227:46-51. PubMed

Traber MG, Leonard SW, Bobe G, Fu X, Saltzman E, Grusak MA, Booth SL (2015) α-Tocopherol disappearance rates from plasma depend on lipid concentrations: studies using deuterium-labeled collard greens in younger and older adults. Am J Clin Nutr 101:752-759. PubMed

Watts EJ, Shen Y, Lansky EP, Nevo E, Bobe G, Traber MG. (2015) High environmental stress yields greater tocotrienol content while changing vitamin E profiles of wild emmer wheat seeds. J Med Food 18:216-223. PubMed

Angelo G, Drake VJ, Frei B. (2014) Efficacy of multivitamin/mineral supplementation to reduce chronic disease risk: a critical review of the evidence from observational studies and randomized controlled trials. Crit Rev Food Sci Nutr 55:1968-1991. PubMed

Athinarayanan S, Wei R, Zhang M, Bai S, Traber MG, Yates K, Cummings OW, Molleston J, Liu W, Chalasani N. (2014) Genetic polymorphism of cytochrome P450 4F2, vitamin E level and histological response in adults and children with nonalcoholic fatty liver disease who participated in PIVENS and TONIC clinical trials. PLoS One 9:e95366. PubMed

Cavender G, Liu M, Hobbs D, Frei B, Strik B, Zhao Y. (2014) Effects of different organic weed management strategies on the physicochemical, sensory, and antioxidant properties of machine-harvested blackberry fruits. J Food Sci 79:S2107-S2116. PubMed

Farley SM, Leonard SW, Stevens JF, Traber MG. (2014) Deuterium-labeled phylloquinone fed to α-tocopherol-injected rats demonstrates sensitivity of low phylloquinone-containing tissues to menaquinone-4 depletion. Mol Nutr Food Res 58:1610-1619. PubMed

Forman HJ, Traber M, Ursini F. (2014) Antioxidants: GRABbing new headlines. Free Radic Biol Med 66:1-2. PubMed

Frei B, Ames BN, Blumberg JB, Willett WC. (2014) Enough is enough.  Ann Intern Med 160:807. PubMed

Gray NE, Morré J, Kelley J, Maier CS, Stevens JF, Quinn JF, Soumyanath A. (2014) Caffeoylquinic acids in Centella asiatica protect against amyloid-β toxicity. J Alzheimers Dis 40:359-373. PubMed

Hall JA, Bobe G, Vorachek WR, Kasper K, Traber MG, Mosher WD, Pirelli GJ, Gamroth M. (2014) Effect of supranutritional organic selenium supplementation on postpartum blood micronutrients, antioxidants, metabolites, and inflammation biomarkers in selenium-replete dairy cows. Biol Trace Elem Res 161:272-287. PubMed

Humpf HU, Schneider C, Stevens JF. (2014) Functional food--where do we go? Mol Nutr Food Res 58:5-6. PubMed

Kramer CM, Launis KL, Traber MG, Ward DP. (2014) Vitamin E levels in soybean (Glycine max (L.) Merr.) expressing a p-hydroxyphenylpyruvate gene from oat (Avena sativa L.). J Agric Food Chem 62:3453-3457. PubMed

Lebold KM, Kirkwood JS, Taylor AW, Choi J, Barton CL, Miller GW, Du JL, Jump DB, Stevens JF, Tanguay RL, Traber MG. (2014) Novel liquid chromatography-mass spectrometry method shows that vitamin E deficiency depletes arachidonic and docosahexaenoic acids in zebrafish (Danio rerio) embryos. Redox Biol 172:105-113. PubMed

Lebold KM, Traber MG. (2014) Interactions between α-tocopherol, polyunsaturated fatty acids, and lipoxygenases during embryogenesis. Free Radic Biol Med 66:13-19. PubMed

Legette L, Karnpracha C, Reed RL, Choi J, Bobe G, Christensen JM, Rodriguez-Proteau R, Purnell JQ, Stevens JF. (2014) Human pharmacokinetics of xanthohumol, an antihyperglycemic flavonoid from hops. Mol Nutr Food Res 58:248-255. PubMed

Lykkesfeldt J, Michels AJ, Frei B. (2014) Vitamin C. Adv Nutr 5:16-18. PubMed

Mah E, Pei R, Guo Y, Masterjohn C, Ballard KD, Taylor BA, Taylor AW, Traber MG, Volek JS, Bruno RS. (2014) Greater γ-tocopherol status during acute smoking abstinence with nicotine replacement therapy improved vascular endothelial function by decreasing 8-iso-15(S)-prostaglandin F2α.  Exp Biol Med 240:527-533. PubMed

McEvoy CT, Schilling D, Clay N, Jackson K, Go MD, Spitale P, Bunten C, Leiva M, Gonzales D, Hollister-Smith J, Durand M, Frei B, Buist AS, Peters D, Morris CD, Spindel ER. (2014) Vitamin C supplementation for pregnant smoking women and pulmonary function in their newborn infants: a randomized clinical trial.  JAMA 311:2074-2082. PubMed

Miller GW, Truong L, Barton CL, Labut EM, Lebold KM, Traber MG, Tanguay RL. (2014) The influences of parental diet and vitamin E intake on the embryonic zebrafish transcriptome. Comp Biochem Physiol Part D Genomics Proteomics 10C:22-29. PubMed

Motorykin I, Traber MG, Tanguay RL, Maier CS. (2014) Proteome-driven elucidation of adaptive responses to combined vitamin E and C deficiency in Zebrafish. J Proteome Res 13:1647-1656. PubMed

Murer SB, Aeberli I, Braegger CP, Gittermann M, Hersberger M, Leonard SW, Taylor AW, Traber MG, Zimmermann MB. (2014) Antioxidant supplements reduced oxidative stress and stabilized liver function tests but did not reduce inflammation in a randomized controlled trial in obese children and adolescents. J Nutr 144:193-201. PubMed

Tripathy S, Lytle KA, Stevens RD, Bain JR, Newgard CB, Greenberg AS, Huang LS, Jump DB. (2014) Fatty acid elongase-5 (Elovl5) regulates hepatic triglyceride catabolism in obease C57BL/6J mice.  J Lipid Res 55:1448-1464. PubMed

Traber MG. (2014) Vitamin E inadequacy in humans: causes and consequences. Adv Nutr 5:503-514. PubMed

Traber MG. (2014) Vitamin K conundrums. Mol Nutr Food Res 58:1589. PubMed

Warnock JJ, Spina J, Bobe G, Duesterdieck-Zellmer KF, Ott J, Baltzer WI, Bay BK. (2014) Culture of canine synoviocytes on porcine intestinal submucosa scaffolds as a strategy for meniscal tissue engineering for treatment of meniscal injury in dogs. Vet J 199:49-56. PubMed

Wei H, Zhang WJ, LeBoeuf R, Frei B. (2014) Copper induces—and copper chelation by tetrathiomolybdate inhibits—endothelial activation in vitro. Redox Report 19:40-48. PubMed


Cancer Prevention and Intervention

Harper TA Jr, Morré J, Lauer FT, McQuistan TJ, Hummel JM, Burchiel SW, Williams DE. (2015) Analysis of dibenzo[def,p]chrysene-deoxyadenosine adducts in wild-type and cytochrome P450 1b1 knockout mice using stable-isotope dilution UHPLC-MS/MS. Mutat Res Genet Toxicol Environ Mutagen 782:51-56. PubMed

Tilton SC, Siddens LK, Krueger SK, Larkin AJ, Löhr CV, Williams DE, Baird WM, Waters KM. (2015) Mechanism-based classification of PAH mixtures to predict carcinogenic potential. Toxicol Sci 146:135-145. PubMed

Atwell LL, Beaver LM, Shannon J, Williams DE, Dashwood RH, Ho E. (2015) Epigenetic regulation by sulforaphane: Opportunities for breast and prostate cancer chemoprevention. Curr Pharmacol Rep 1:102-111. PubMed

Siddens LK, Bunde KL, Harper TA Jr, McQuistan TJ, Löhr CV, Bramer LM, Waters KM, Tilton SC, Krueger SK, Williams DE, Baird WM. (2015) Cytochrome P450 1b1 in polycyclic aromatic hydrocarbon (PAH)-induced skin carcinogenesis: Tumorigenicity of individual PAHs and coal-tar extract, DNA adduction and expression of select genes in the Cyp1b1 knockout mouse. Toxicol Appl Pharmacol 287:149-160. PubMed

Watson GW, Wickramasekara S, Fang Y, Palomera-Sanchez Z, Maier CS, Williams DE, Dashwood RH, Perez VI, Ho E. (2015) Analysis of autophagic flux in response to sulforaphane in metastatic prostate cancer cells. Mol Nutr Food Res 59:1954-1961. PubMed

Rajendran P, Dashwood WM, Li L, Kang Y, Kim E, Johnson G, Fischer KA, Löhr CV, Williams DE, Ho E, Yamamoto M, Lieberman DA, Dashwood RH. (2015) Nrf2 status affects tumor growth, HDAC3 gene promoter associations, and the response to sulforaphane in the colon. Clin Epigenetics 7:102. PubMed

Abbas A, Hall JA, Patterson WL 3rd, Ho E, Hsu A, Al-Mulla F, Georgel PT. (2015) Sulforaphane modulates telomerase activity via epigenetic regulation in prostate cancer cell lines. Biochem Cell Biol 9:1-11. PubMed

Atwell LL, Zhang Z, Mori M, Farris PE, Vetto JT, Naik AM, Oh KY, Thuillier P, Ho E, Shannon J. (2015) Sulforaphane bioavailability and chemopreventive activity in women scheduled for breast biopsy. Cancer Prev Res 8:1184-1191. PubMed

Watson GW, Wickramasekara S, Maier CS, Williams DE, Dashwood RH, Ho E. (2015) Assessment of global proteome in LNCaP cells by 2D-RP/RP LC-MS/MS following sulforaphane exposure. EuPA Open Proteom 9:34-40. PubMed

Watson GW, Wickramasekara S, Fang Y, Maier CS, Williams DE, Dashwood RH, Perez VI, Ho E. (2015) HDAC6 activity is not required for basal autophagic flux in metastatic prostate cancer cells. Exp Biol Med, Epub ahead of print. PubMed

Atwell LL, Hsu A, Wong CP, Stevens JF, Bella D, Yu TW, Pereira CB, Löhr CV, Christensen JM, Dashwood RH, Williams DE, Shannon J, Ho E. (2015) Absorption and chemopreventive targets of sulforaphane in humans following consumption of broccoli sprouts or a myrosinase-treated broccoli sprout extract. Mol Nutr Food Res 59:424-433. PubMed

Huang L, Drake VJ, Ho E. (2015) Zinc. Adv Nutr 6:224-226. PubMed

Wong CP, Rinaldi NA, Ho E. (2015) Zinc deficiency enhanced inflammatory response by increasing immune cell activation and inducing IL6 promoter demethylation. Mol Nutr Food Res 59:991-999. PubMed

Beaver LM, Buchanan A, Sokolowski El, Riscoe AN, Wong CP, Chang JH, Löhr CV, Williams DE, Dashwood RH, Ho E. (2014) Transcriptome analysis reveals a dynamic and differential transcriptional response to sulforaphane in normal and prostate cancer cells and suggests a role for Sp1 in chemoprevention. Mol Nutr Food Res 58:2001-2013. PubMed

Henderson MC, Siddens LK, Krueger SK, Stevens JF, Kedzie K, Fang WK, Heidelbaugh T, Nguyen P, Chow K, Garst M, Gil D, Williams DE. (2014) Flavin-containing monoxygenase S-oxygenation of a series of thioureas and thiones.  Toxicol Appl Pharmacol 278:91-99. PubMed

Madeen E, Corley RA, Crowell S, Turteltaub K, Ognibene T, Malfatti M, McQuistan TJ, Garrard M, Sudakin D, Williams DE. (2014) Human in vivo pharmacokinetics of [14C]dibenzo[def,p]chrysene by accelerator mass spectrometry following oral microdosing.  Chem Res Toxicol 28:126-134. PubMed

Siddens LK, Krueger SK, Henderson MC, Williams DE. (2014) Mammalian flavin-containing monooxygenase (FMO) as a source of hydrogen peroxide. Biochem Pharmacol 89:141-147. PubMed

Warnock JJ, Bobe G, Duesterdieck-Zellmer KF, Spina J, Ott J, Baltzer WI, Bay BK. (2014) Growth factor treated tensioned synoviocyte neotissues: Towards meniscal bioscaffold tissue engineering. Vet J 200:22-30. PubMed

Wong CP, Hsu A, Buchanan A, Palomera-Sanchez Z, Beaver LM, Houseman EA, Williams DE, Dashwood RH, Ho E. (2014) Effects of sulforaphane and 3,3'-diindolylmethane on genome-wide promoter methylation in normal prostate epithelial cells and prostate cancer cells. PLoS One 9:e86787. PubMed


Healthy Aging Program

Magnusson KR, Hauck L, Jeffrey BM, Elias V, Humphrey A, Nath R, Perrone A, Bermudez LE. (2015) Relationships between diet-related changes in the gut microbiome and cognitive flexibility. Neuroscience 300:128-140. PubMed

Yu Z, Sunchu B, Fok WC, Alshaikh N, Pérez VI. (2015) Gene expression in the liver of female, but not male mice treated with rapamycin resembles changes observed under dietary restriction. Springerplus 4:174. PubMed

Smith EJ, Shay KP, Thomas NO, Butler JA, Finlay LF, Hagen TM. (2015) Age-related loss of hepatic Nrf2 protein homeostasis: Potential role for heightened expression of miR-146a. Free Radic Biol Med 89:1184-1191. PubMed

Gombart AF. (2015) The end of the line for neutrophils. Blood 125:1688-1690. PubMed

Kerr DC, Zava DT, Piper WT, Saturn SR, Frei B, Gombart AF. (2015) Associations between vitamin D levels and depressive symptoms in healthy young adult women. Psychiatry Res 227:46-51. PubMed

Pride H, Yu Z, Sunchu B, Mochnick J, Coles A, Zhang Y, Buffenstein R, Hormsby PJ, Austad SN, Pérez VI. (2015) Long-lived species have improvoed proteostasis compared to phylogenetically-related shorter-lived species.  Biochem Biophys Res Comm 457:669-675. PubMed

Roemeling MD, Williams J, Beckman JS, Hurst, JK. (2015) Imidazole catalyzes chlorination by unreactive primary chloramines.  Free Radic Biol Med 82:167-178. PubMed

Dhawan P, Wei R, Sun C, Gombart AF, Koeffler HP, Diamond G, Christakos S. (2015) C/EBPα and the vitamin D receptor cooperate in the regulation of cathelicidin in lung epithelial cells.  J Cell Physiol 230:464-472. PubMed

Yu Z, Wang R, Fok WC, Coles A, Salmon AB, Pérez VI. (2015) Rapamycin and dietary restriction induce metabolically distinctive changes in mouse liver. J Gerontol A Biol Sci Med Sci 70:410-420. PubMed

Fok WC, Bokov A, Gelfond J, Yu Z, Zhang Y, Doderer M, Chen Y, Javors M, Wood WH 3rd, Zhang Y, Becker KG, Richardson A, Pérez VI. (2014) Combined treatment of rapamycin and dietary restriction has a larger effect on the transcriptome and metabolome of liver. Aging Cell 13:311-319. PubMed

Fok WC, Chen Y, Bokov A, Zhang Y, Salmon AB, Diaz V, Javors M, Wood WH 3rd, Zhang Y, Becker KG, Pérez VI, Richardson A. (2014) Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome. PLoS One 9:e83988. PubMed

Fok WC, Livi C, Bokov A, Yu Z, Chen Y, Richardson A, Pérez VI. (2014) Short-term rapamycin treatment in mice has few effects on the transcriptome of white adipose tissue compared to dietary restriction. Mech Ageing Dev 140:23-29. PubMed

Guo C, Gombart AF. (2014) The antibiotic effects of vitamin D. Endocr Metab Immune Disord Drug Targets 14:255-266. PubMed

Guo C, Sinnott B, Niu B, Lowry MB, Fantacone ML, Gombart AF. (2014) Synergistic induction of human cathelicidin antimicrobial peptide gene expression by vitamin D and stilbenoids. Mol Nutr Food Res 58:528-536. PubMed

Keith D, Finlay L, Butler J, Gómez L, Smith E, Moreau R, Hagen T. (2014) Lipoic acid entrains the hepatic circadian clock and lipid metabolic proteins that have been desynchronized with advanced age.  Biochem Biophys Res Commun 450:324-329. PubMed

Lowry MB, Guo C, Borregaard N, Gombart AF. (2014) Regulation of the human cathelicidin antimicrobial peptide gene by 1α,25-dihydroxyvitamin D3 in primary immune cells. J Steroid Biochem Mol Biol 143:183-91. PubMed

Okamoto R, Gery S, Gombart AF, Wang X, Castellani LW, Akagi T, Chen S, Arditi M, Ho Q, Lusis AJ, Li Q, Koeffler HP. (2014) Deficiency of CCAAT/enhancer binding protein-epsilon reduces atherosclerotic lesions in LDLR-/- mice. PLoS One. 9:e85341. PubMed

Roberts BR, Lim NK, McAllum EJ, Donnelly PS, Hare DJ, Doble PA, Turner BJ, Price KA, Chun Lim S, Paterson BM, Hickey JL, Rhoads TW, Williams JR, Kanninen KM, Hung LW, Liddell JR, Grubman A, Monty JF, Llanos RM, Kramer DR, Mercer JF, Bush AI, Masters CL, Duce JA, Li QX, Beckman JS, Barnham KJ, White AR, Crouch PJ. (2014) Oral treatment with CuII(atsm) increases mutant SOD1 in vivo but protects motor neurons and improves the phenotype of a transgenic mouse model of amyotrophic lateral sclerosis. J Neurosci 34:8021-8031. PubMed

Schwarzländer M, Wagner S, Ermakova YG, Belousov VV, Radi R, Beckman JS, Buettner GR, Demaurex N, Duchen MR, Forman HJ, Fricker MD, Gems D, Halestrap AP, Halliwell B, Jakob U, Johnston IG, Jones NS, Logan DC, Morgan B, Müller FL, Nicholls DG, Remington SJ, Schumacker PT, Winterbourn CC, Sweetlove LJ, Meyer AJ, Dick TP, Murphy MP. (2014) The 'mitoflash' probe cpYFP does not respond to superoxide. Nature 514:E12-14. PubMed

Triana-Martínez F, López-Diazguerrero NE, Maciel-Barón LA, Morales-Rosales SL, Galván-Arzate S, Fernandez-Perrino FJ, Zentella A, Pérez VI, Gomez-Quiroz LE, Königsberg M. (2014) Cell proliferation arrest and redox state status as part of different stages during senescence establishment in mouse fibroblasts. Biogerontology 15:165-176. PubMed

Voinov VG, Bennett SE, Beckman JS, Barofsky DF. (2014) ECD of tyrosine phosphorylation in a triple quadrupole mass spectrometer with a radio-frequency-free electromagnetostatic cell. J Am Soc Mass Spectrom 25:1730-1738. PubMed

Zamzow DR, Elias V, Legette LL, Choi J, Stevens, JF, Magnusson KR. (2014) Xanthohumol improved cognitive flexibility in young mice. Behav Brain Res 275:1-10. PubMed