Cardiometabolic Disease Prevention

Kerr DC, Zava DT, Piper WT, Saturn SR, Frei B, Gombart AF. (2015) Associations between vitamin D levels and depressive symptoms in healthy young adult women. Psychiatry Res, Epub ahead of print. PubMed

Traber MG, Leonard SW, Bobe G, Fu X, Saltzman E, Grusak MA, Booth SL (2015) α-Tocopherol disappearance rates from plasma depend on lipid concentrations: studies using deuterium-labeled collard greens in younger and older adults. Am J Clin Nutr, Epub ahead of print. PubMed

Watts EJ, Shen Y, Lansky EP, Nevo E, Bobe G, Traber MG. (2015) High environmental stress yields greater tocotrienol content while changing vitamin E profiles of wild emmer wheat seeds. J Med Food 18:216-223. PubMed

Angelo G, Drake VJ, Frei B. (2014) Efficacy of multivitamin/mineral supplementation to reduce chronic disease risk: a critical review of the evidence from observational studies and randomized controlled trials. Crit Rev Food Sci Nutr, Epub ahead of print. PubMed

Athinarayanan S, Wei R, Zhang M, Bai S, Traber MG, Yates K, Cummings OW, Molleston J, Liu W, Chalasani N. (2014) Genetic polymorphism of cytochrome P450 4F2, vitamin E level and histological response in adults and children with nonalcoholic fatty liver disease who participated in PIVENS and TONIC clinical trials. PLoS One 9:e95366. PubMed

Cavender G, Liu M, Hobbs D, Frei B, Strik B, Zhao Y. (2014) Effects of different organic weed management strategies on the physicochemical, sensory, and antioxidant properties of machine-harvested blackberry fruits. J Food Sci 79:S2107-S2116. PubMed

Farley SM, Leonard SW, Stevens JF, Traber MG. (2014) Deuterium-labeled phylloquinone fed to α-tocopherol-injected rats demonstrates sensitivity of low phylloquinone-containing tissues to menaquinone-4 depletion. Mol Nutr Food Res 58:1610-1619. PubMed

Forman HJ, Traber M, Ursini F. (2014) Antioxidants: GRABbing new headlines. Free Radic Biol Med 66:1-2. PubMed

Frei B, Ames BN, Blumberg JB, Willett WC. (2014) Enough is enough.  Ann Intern Med 160:807. PubMed

Gray NE, Morré J, Kelley J, Maier CS, Stevens JF, Quinn JF, Soumyanath A. (2014) Caffeoylquinic acids in Centella asiatica protect against amyloid-β toxicity. J Alzheimers Dis 40:359-373. PubMed

Hall JA, Bobe G, Vorachek WR, Kasper K, Traber MG, Mosher WD, Pirelli GJ, Gamroth M. (2014) Effect of supranutritional organic selenium supplementation on postpartum blood micronutrients, antioxidants, metabolites, and inflammation biomarkers in selenium-replete dairy cows. Biol Trace Elem Res 161:272-287. PubMed

Humpf HU, Schneider C, Stevens JF. (2014) Functional food--where do we go? Mol Nutr Food Res 58:5-6. PubMed

Kramer CM, Launis KL, Traber MG, Ward DP. (2014) Vitamin E levels in soybean (Glycine max (L.) Merr.) expressing a p-hydroxyphenylpyruvate gene from oat (Avena sativa L.). J Agric Food Chem 62:3453-3457. PubMed

Lebold KM, Kirkwood JS, Taylor AW, Choi J, Barton CL, Miller GW, Du JL, Jump DB, Stevens JF, Tanguay RL, Traber MG. (2014) Novel liquid chromatography-mass spectrometry method shows that vitamin E deficiency depletes arachidonic and docosahexaenoic acids in zebrafish (Danio rerio) embryos. Redox Biol 172:105-113. PubMed

Lebold KM, Traber MG. (2014) Interactions between α-tocopherol, polyunsaturated fatty acids, and lipoxygenases during embryogenesis. Free Radic Biol Med 66:13-19. PubMed

Legette L, Karnpracha C, Reed RL, Choi J, Bobe G, Christensen JM, Rodriguez-Proteau R, Purnell JQ, Stevens JF. (2014) Human pharmacokinetics of xanthohumol, an antihyperglycemic flavonoid from hops. Mol Nutr Food Res 58:248-255. PubMed

Lykkesfeldt J, Michels AJ, Frei B. (2014) Vitamin C. Adv Nutr 5:16-18. PubMed

Mah E, Pei R, Guo Y, Masterjohn C, Ballard KD, Taylor BA, Taylor AW, Traber MG, Volek JS, Bruno RS. (2014) Greater γ-tocopherol status during acute smoking abstinence with nicotine replacement therapy improved vascular endothelial function by decreasing 8-iso-15(S)-prostaglandin F2α.  Exp Biol Med (Maywood), Epub ahead of print. PubMed

McEvoy CT, Schilling D, Clay N, Jackson K, Go MD, Spitale P, Bunten C, Leiva M, Gonzales D, Hollister-Smith J, Durand M, Frei B, Buist AS, Peters D, Morris CD, Spindel ER. (2014) Vitamin C supplementation for pregnant smoking women and pulmonary function in their newborn infants: a randomized clinical trial.  JAMA 311:2074-2082. PubMed

Miller GW, Truong L, Barton CL, Labut EM, Lebold KM, Traber MG, Tanguay RL. (2014) The influences of parental diet and vitamin E intake on the embryonic zebrafish transcriptome. Comp Biochem Physiol Part D Genomics Proteomics 10C:22-29. PubMed

Motorykin I, Traber MG, Tanguay RL, Maier CS. (2014) Proteome-driven elucidation of adaptive responses to combined vitamin E and C deficiency in Zebrafish. J Proteome Res 13:1647-1656. PubMed

Murer SB, Aeberli I, Braegger CP, Gittermann M, Hersberger M, Leonard SW, Taylor AW, Traber MG, Zimmermann MB. (2014) Antioxidant supplements reduced oxidative stress and stabilized liver function tests but did not reduce inflammation in a randomized controlled trial in obese children and adolescents. J Nutr 144:193-201. PubMed

Tripathy S, Lytle KA, Stevens RD, Bain JR, Newgard CB, Greenberg AS, Huang LS, Jump DB. (2014) Fatty acid elongase-5 (Elovl5) regulates hepatic triglyceride catabolism in obease C57BL/6J mice.  J Lipid Res 55:1448-1464. PubMed

Traber MG. (2014) Vitamin E inadequacy in humans: causes and consequences. Adv Nutr 5:503-514. PubMed

Traber MG. (2014) Vitamin K conundrums. Mol Nutr Food Res 58:1589. PubMed

Warnock JJ, Spina J, Bobe G, Duesterdieck-Zellmer KF, Ott J, Baltzer WI, Bay BK. (2014) Culture of canine synoviocytes on porcine intestinal submucosa scaffolds as a strategy for meniscal tissue engineering for treatment of meniscal injury in dogs. Vet J 199:49-56. PubMed

Wei H, Zhang WJ, LeBoeuf R, Frei B. (2014) Copper induces—and copper chelation by tetrathiomolybdate inhibits—endothelial activation in vitro. Redox Report 19:40-48. PubMed

Cancer Prevention and Intervention

Atwell LL, Hsu A, Wong CP, Stevens JF, Bella D, Yu TW, Pereira CB, Löhr CV, Christensen JM, Dashwood RH, Williams DE, Shannon J, Ho E. (2015) Absorption and chemopreventive targets of sulforaphane in humans following consumption of broccoli sprouts or a myrosinase-treated broccoli sprout extract.  Mol Nutr Food Res 59:424-433. PubMed

Huang L, Drake VJ, Ho E. (2015) Zinc. Adv Nutr 6:224-226. PubMed

Wong CP, Rinaldi NA, Ho E. (2015) Zinc deficiency enhanced inflammatory response by increasing immune cell activation and inducing IL6 promoter demethylation.  Mol Nutr Food Res, Epub ahead of print. PubMed

Beaver LM, Buchanan A, Sokolowski El, Riscoe AN, Wong CP, Chang JH, Löhr CV, Williams DE, Dashwood RH, Ho E. (2014) Transcriptome analysis reveals a dynamic and differential transcriptional response to sulforaphane in normal and prostate cancer cells and suggests a role for Sp1 in chemoprevention. Mol Nutr Food Res 58:2001-2013. PubMed

Henderson MC, Siddens LK, Krueger SK, Stevens JF, Kedzie K, Fang WK, Heidelbaugh T, Nguyen P, Chow K, Garst M, Gil D, Williams DE. (2014) Flavin-containing monoxygenase S-oxygenation of a series of thioureas and thiones.  Toxicol Appl Pharmacol 278:91-99. PubMed

Madeen E, Corley RA, Crowell S, Turteltaub K, Ognibene T, Malfatti M, McQuistan TJ, Garrard M, Sudakin D, Williams DE. (2014) Human in vivo pharmacokinetics of [14C]dibenzo[def,p]chrysene by accelerator mass spectrometry following oral microdosing.  Chem Res Toxicol, Epub ahead of print. PubMed

Siddens LK, Krueger SK, Henderson MC, Williams DE. (2014) Mammalian flavin-containing monooxygenase (FMO) as a source of hydrogen peroxide. Biochem Pharmacol 89:141-147. PubMed

Warnock JJ, Bobe G, Duesterdieck-Zellmer KF, Spina J, Ott J, Baltzer WI, Bay BK. (2014) Growth factor treated tensioned synoviocyte neotissues: Towards meniscal bioscaffold tissue engineering. Vet J 200:22-30. PubMed

Wong CP, Hsu A, Buchanan A, Palomera-Sanchez Z, Beaver LM, Houseman EA, Williams DE, Dashwood RH, Ho E. (2014) Effects of sulforaphane and 3,3'-diindolylmethane on genome-wide promoter methylation in normal prostate epithelial cells and prostate cancer cells. PLoS One 9:e86787. PubMed

Healthy Aging Program

Gombart AF. (2015) The end of the line for neutrophils. Blood 125:1688-1690. PubMed

Kerr DC, Zava DT, Piper WT, Saturn SR, Frei B, Gombart AF. (2015) Associations between vitamin D levels and depressive symptoms in healthy young adult women.  Psychiatry Res, Epub ahead of print. PubMed

Pride H, Yu Z, Sunchu B, Mochnick J, Coles A, Zhang Y, Buffenstein R, Hormsby PJ, Austad SN, Pérez VI. (2015) Long-lived species have improvoed proteostasis compared to phylogenetically-related shorter-lived species.  Biochem Biophys Res Comm 457:669-675. PubMed

Roemeling MD, Williams J, Beckman JS, Hurst, JK. (2015) Imidazole catalyzes chlorination by unreactive primary chloramines.  Free Radic Biol Med 82:167-178. PubMed

Dhawan P, Wei R, Sun C, Gombart AF, Koeffler HP, Diamond G, Christakos S. (2014) C/EBPα and the vitamin D receptor cooperate in the regulation of cathelicidin in lung epithelial cells.  J Cell Physiol, Epub ahead of print. PubMed

Fok WC, Bokov A, Gelfond J, Yu Z, Zhang Y, Doderer M, Chen Y, Javors M, Wood WH 3rd, Zhang Y, Becker KG, Richardson A, Pérez VI. (2014) Combined treatment of rapamycin and dietary restriction has a larger effect on the transcriptome and metabolome of liver. Aging Cell 13:311-319. PubMed

Fok WC, Chen Y, Bokov A, Zhang Y, Salmon AB, Diaz V, Javors M, Wood WH 3rd, Zhang Y, Becker KG, Pérez VI, Richardson A. (2014) Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome. PLoS One 9:e83988. PubMed

Fok WC, Livi C, Bokov A, Yu Z, Chen Y, Richardson A, Pérez VI. (2014) Short-term rapamycin treatment in mice has few effects on the transcriptome of white adipose tissue compared to dietary restriction. Mech Ageing Dev 140:23-29. PubMed

Guo C, Gombart AF. (2014) The antibiotic effects of vitamin D. Endocr Metab Immune Disord Drug Targets 14:255-266. PubMed

Guo C, Sinnott B, Niu B, Lowry MB, Fantacone ML, Gombart AF. (2014) Synergistic induction of human cathelicidin antimicrobial peptide gene expression by vitamin D and stilbenoids. Mol Nutr Food Res 58:528-536. PubMed

Keith D, Finlay L, Butler J, Gómez L, Smith E, Moreau R, Hagen T. (2014) Lipoic acid entrains the hepatic circadian clock and lipid metabolic proteins that have been desynchronized with advanced age.  Biochem Biophys Res Commun 450:324-329. PubMed

Lowry MB, Guo C, Borregaard N, Gombart AF. (2014) Regulation of the human cathelicidin antimicrobial peptide gene by 1α,25-dihydroxyvitamin D3 in primary immune cells. J Steroid Biochem Mol Biol 143:183-91. PubMed

Okamoto R, Gery S, Gombart AF, Wang X, Castellani LW, Akagi T, Chen S, Arditi M, Ho Q, Lusis AJ, Li Q, Koeffler HP. (2014) Deficiency of CCAAT/enhancer binding protein-epsilon reduces atherosclerotic lesions in LDLR-/- mice. PLoS One. 9:e85341. PubMed

Roberts BR, Lim NK, McAllum EJ, Donnelly PS, Hare DJ, Doble PA, Turner BJ, Price KA, Chun Lim S, Paterson BM, Hickey JL, Rhoads TW, Williams JR, Kanninen KM, Hung LW, Liddell JR, Grubman A, Monty JF, Llanos RM, Kramer DR, Mercer JF, Bush AI, Masters CL, Duce JA, Li QX, Beckman JS, Barnham KJ, White AR, Crouch PJ. (2014) Oral treatment with CuII(atsm) increases mutant SOD1 in vivo but protects motor neurons and improves the phenotype of a transgenic mouse model of amyotrophic lateral sclerosis. J Neurosci 34:8021-8031. PubMed

Schwarzländer M, Wagner S, Ermakova YG, Belousov VV, Radi R, Beckman JS, Buettner GR, Demaurex N, Duchen MR, Forman HJ, Fricker MD, Gems D, Halestrap AP, Halliwell B, Jakob U, Johnston IG, Jones NS, Logan DC, Morgan B, Müller FL, Nicholls DG, Remington SJ, Schumacker PT, Winterbourn CC, Sweetlove LJ, Meyer AJ, Dick TP, Murphy MP. (2014) The 'mitoflash' probe cpYFP does not respond to superoxide. Nature 514:E12-14. PubMed

Triana-Martínez F, López-Diazguerrero NE, Maciel-Barón LA, Morales-Rosales SL, Galván-Arzate S, Fernandez-Perrino FJ, Zentella A, Pérez VI, Gomez-Quiroz LE, Königsberg M. (2014) Cell proliferation arrest and redox state status as part of different stages during senescence establishment in mouse fibroblasts. Biogerontology 15:165-176. PubMed

Voinov VG, Bennett SE, Beckman JS, Barofsky DF. (2014) ECD of tyrosine phosphorylation in a triple quadrupole mass spectrometer with a radio-frequency-free electromagnetostatic cell. J Am Soc Mass Spectrom 25:1730-1738. PubMed

Yu Z, Wang R, Fok WC, Coles A, Salmon AB, Pérez VI. (2014) Rapamycin and dietary restriction induce metabolically distinctive changes in mouse liver. J Gerontol A Biol Sci Med Sci, Epub ahead of print. PubMed

Zamzow DR, Elias V, Legette LL, Choi J, Stevens, JF, Magnusson KR. (2014) Xanthohumol improved cognitive flexibility in young mice. Behav Brain Res 275:1-10. PubMed