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Research Newsletter-Spring/Summer 2008


Dr. George Bailey retired at the end of February after a nearly 30-year career at Oregon State University and after over five years as a Principal Investigator in LPI. George earned a B.S. in chemistry at the University of Southern California, followed by a Ph.D. in biochemistry from the University of California-Berkeley. He joined OSU in 1979 as an assistant professor in the Department of Food Science and Technology and was honored in 1998 with the title of Distinguished Professor in the Department of Environmental and Molecular Toxicology. He served as the director of OSU's Marine and Freshwater Biomedical Sciences Center from 1985 to 2002. George has published over 150 papers in peer-reviewed scientific journals and has won several awards for outstanding research, including the Sixth Prince Hitachi Prize in Comparative Oncology in 2001. Over the years, he has also mentored many graduate students at OSU.

George has worked most recently in the area of "Cancer Chemoprevention by Chlorophylls, and Basic Mechanisms of Carcinogenesis." He has been especially interested in how dietary phytochemicals (plant-derived chemicals that may affect health) inhibit cancer in animal models and the extrapolation of that research to humans. Some of his early work is discussed in the interview that begins on the first page of this newsletter. Using the rainbow trout model, George and his colleagues have been able to achieve unprecedented statistical power using the dose-dose matrix experimental design in which various doses of carcinogens are tested against various doses of putative cancer chemoprotective phytochemicals. He has also assembled the most comprehensive database of carcinogen-DNA adducts as early biomarkers for cancer chemoprotection by phytochemicals in any animal model. Based on his results in trout showing that liver cancer induced by aflatoxin could be inhibited by chlorophyllin through a blocking mechanism (chlorophyllin binds to aflatoxin, preventing its uptake in the body), George and his colleagues initiated a human trial in China where people are unavoidably exposed to dietary aflatoxin. The research team measured cancer biomarkers in the urine, which were substantially decreased in people taking chlorophyllin supplements.

George was one of several members of a faculty advisory committee established by Dr. Richard Scanlan, OSU's Dean of Research in 1995, to advise OSU's then-President, Dr. John Byrne, on the possible establishment of the Linus Pauling Institute at OSU. Those deliberations were successful, and the Linus Pauling Institute moved from Palo Alto, California, in 1996 to become a research institute at OSU.

George will continue to think about science and fly-fish for trout in the Cascade Mountains of Oregon, but probably won't return to the surfing he enjoyed as a student in southern California.

Last updated June 2008