Office: 431 Weniger Hall
Telephone: (541) 737-3164
Fax: (541) 737-7966
Email Address: firstname.lastname@example.org
Mailing/Express Delivery Address:
George Bailey, Ph.D.
Marine and Freshwater Biomedical Sciences Center
Oregon State University
435 Weniger Hall
Corvallis, OR 97331
Research interests explore mechanisms of chemical carcinogenesis and its modulation by dietary and environmental factors. Two important cancer preventive agents are being extensively studied -- indole-3-carbinol for its promise in prevention of breast cancer, and chlorophyllin, which we are testing in a clinical trial for its potential to reduce aflatoxin-related liver cancer in China. The main experimental model is the rainbow trout, supplemented by studies with traditional rodent models. Biochemical and molecular biology approaches are employed to understand carcinogen and modulator pharmacokinetics, metabolic pathways, DNA damage and repair, mutagenic activation of oncogenes and tumor suppressor genes, cell replication and apoptosis, and how these pathways are altered by dietary treatment with chemopreventive agents. Exploratory studies are examining gene transfer to improve the utility of fish as surrogate models for cancer research. This work is carried out in collaboration with other researchers in the two NIEHS centers at OSU.
|1963||A.A., Chemistry, El Camino College|
|1965||B.S., Chemistry, University of Southern California|
|1969||Ph.D., Biochemistry, University of California at Berkeley|
|1969||Instructor in Biochemistry, University of California at Berkeley|
|1969-1971||Postdoctoral Research Associate, University of British Columbia|
|1971-1979||Lecturer, Senior Lecturer, Medical School, Department of Biochemistry, University of Otago, New Zealand|
|1979-1998||Assistant, Associate, Full Professor, Distinguished Professor, Department of Food Science and Technology, Oregon State University|
|1998-2009||Distinguished Professor, Department of Environmental and Molecular Toxicology, Oregon State University|
|1985-2002||Director, Marine and Freshwater Biomedical Sciences Center, Oregon State University|
|2002-2003||Deputy Director, Marine and Freshwater Biomedical Sciences Center, Oregon State University|
|2003-2009||Principal Investigator, Linus Pauling Institute, Oregon State University|
|2009-present||Distinguished Professor Emeritus, Department of Environmental and Molecular Toxicology, Oregon State University|
|2001||Sixth Prince Hitachi Prize in Comparative Oncology, May 2001|
|1999||Award of Merit, Foundation for Promotion of Cancer Research, Japan|
|1998||Japan Strategy of Cancer Control Lecturer, April 1998|
|1995||Distinguished Professor of Food Toxicology, Oregon State University|
|1994||Standing member, NCI Study Section reserve reviewer|
|1994||Japan Environmental Mutagen Society, 1994 Plenary Lecturer|
|1994||Gary E. Costley Award for Achievement in Nutrition|
|1993||Institute of Food Technologists Certificate of Merit award|
|1991||Appointed member, NCI Metabolic Pathology Study Section|
Alpha Gamma Sigma
American Association for Cancer Research
American Association for the Advancement of Science
Phi Lambda Upsilon
Society of Toxicologists
Tilton, S.C., Gerwick, L.G., Hendricks, J.D., Rosato, C.S., Corley-Smith, G., Givan, S.A., Bailey, G.S., Bayne, C.J. and Williams, D.E. (2005) Use of a rainbow trout oligonucleotide microarray to determine transcriptional patterns in aflatoxin B1-induced hepatocellular carcinoma compared to adjacent liver. Toxicol. Sci. 88:319-330.
Tilton, S.C., Givan, S.A., Pereira, C.B., Bailey, G.S. and Williams, D.E. (2006) Toxicogenomic profiling of the hepatic tumor promoters indole-3-carbinol, 17-beta-estradiol and beta-naphthoflavone in rainbow trout. Toxicol. Sci. 90:61-72.
Yu, Z., Loehr, C.V., Fischer, K.A., Louderback, M.A., Krueger, S.K., Dashwood, R.H., Kerkvliet, N.I., Pereira, C.B., Jennings-Gee, J.E., Dance, S.T., Miller, M.S., Bailey, G.S. and Williams, D.E. (2006) In utero exposure of mice to dibenzo[a,l]pyrene produces lymphoma in the offspring: role of the aryl hydrocarbon receptor. Cancer Res. 66:755-762.
Orner, G.A., Roebuck, B.D., Dashwood, R.H. and Bailey, G.S. (2006) Post-initiation chlorophyllin exposure does not modulate aflatoxin-induced foci in the liver and colon of rats. J. Carcinog. 5:1-6.
Wang, R., Dashwood, W.M., Bailey, G.S., Williams, D.E. and Dashwood, R.H. (2006) Tumors from rats treated with 1,2-dimethylhydrazine plus chlorophyllin or indole-3-carbinol contain transcriptional changes in beta-catenin that are independent of beta-catenin mutation status. Mutat. Res. 601:11-18.
Yu, Z,, Mahadevan, B., Lohr, C.V., Fischer, K.A., Louderback, M.A., Krueger, S.K., Pereira, C.B., Albershardt, D.J., Baird, W.M., Bailey, G.S. and Williams, D.E. (2006) Indole-3-carbinol in the maternal diet provides chemoprotection for the fetus against transplacental carcinogenesis by the polycyclic aromatic hydrocarbon, dibenzo[a,l]pyrene. Carcinogenesis 27:2116-2123.
Kwon, D., Yoon, S., Carter, O., Bailey, G.S. and Dashwood, R.H. (2006) Antioxidant and antigenotoxic activities of Angelica keiskei, Oenanthe javanica and Brassica oleracea in the Salmonella mutagenicity assay and in HCT116 human colon cancer cells. Biofactors 26:231-244.
Pratt, M.M., Reddy, A.P., Hendricks, J.D., Pereira, C., Kensler, T.W. and Bailey, G.S. (2007) The importance of carcinogen dose in chemoprevention studies: quantitative interrelationships between, dibenzo[a,l]pyrene dose, chlorophyllin dose, target organ DNA adduct biomarkers and final tumor outcome. Carcinogenesis 28:611-624.
Tilton, S.C., Hendricks, J.D., Orner, G.A., Pereira, C.B., Bailey, G.S. and Williams, D.E. (2007) Gene expression analysis during tumor enhancement by the dietary phytochemical, 3,3'-diindolylmethane, in rainbow trout. Carcinogenesis 28:1589-1598.
Simonich, M.T., Egner, P.A., Roebuck, B.D., Orner, G.A., Jubert, C., Pereira, C., Groopman, J.D., Kensler, T.W., Dashwood, R.H., Williams, D.E. and Bailey, G.S. (2007) Natural chlorophyll inhibits aflatoxin B1-induced multi-organ carcinogenesis in the rat. Carcinogenesis 28:1294-1302.
Carter, O., Dashwood, R.H., Wang, R., Dashwood, W.M., Orner, G.A., Fischer, K.A., Lohr, C.V., Pereira, C.B., Bailey, G.S. and Williams, D.E. (2007) Comparison of white tea, green tea, epigallocatechin-3-gallate, and caffeine as inhibitors of PhIP-induced colonic aberrant crypts. Nutr. Cancer 58:60-65.
Friedman, M., McQuistan, T., Hendricks, J.D., Pereira, C., and Bailey, G.S. (2007) Protective effect of dietary tomatine against dibenzo[a,l]pyrene (DBP)-induced liver and stomach tumors in rainbow trout. Mol. Nutr. Food Res. 51:1485-1491.
Simonich, M.T., McQuistan, T., Jubert, C., Pereira, C., Hendricks, J.D., Schimerlik, M., Zhu, B., Dashwood, R.H., Williams, D.E., and Bailey, G.S. (2007) Low-dose dietary chlorophyll inhibits multi-organ carcinogenesis in the rainbow trout. Food Chem. Toxicol. 46:1014-1024.
Wang, R., Dashwood, W.M., Lohr, C.V., Fischer, K.A., Pereira, C.B., Louderback, M., Nakagama, H., Bailey, G.S., Williams, D.E., and Dashwood, R.H. (2008) Protective versus promotional effects of white tea and caffeine on PhIP-induced tumorigenesis and beta-catenin expression in the rat. Carcinogenesis 29:834-839.
Castro, D.J., Löhr, C.V., Fischer, K.A., Waters, K.M., Webb-Robertson, B.J., Dashwood, R.H., Bailey, G.S., and Williams, D.E. (2009) Identifying efficacious approaches to chemoprevention with chlorophyllin, purified chlorophylls and freeze-dried spinach in a mouse model of transplacental carcinogenesis. Carcinogenesis 30:315-320.
Williams, D.E., Orner, G., Willard, K.D., Tilton, S., Hendricks, J.D., Pereira, C., Benninghoff, A.D., and Bailey, G.S. (2009) Rainbow trout (Oncorhynchus mykiss) and ultra-low dose cancer studies. Comp. Biochem. Physiol. C. Toxicol. Pharmacol. 149:175-181.
Bailey, G.S., Reddy, A.P., Pereira, C.B., Harttig, U., Baird, W., Spitsbergen, J.M., Hendricks, J.D., Orner, G.A., Williams, D.E., Swenberg, J.A. 2009 Nonlinear cancer response at ultralow dose: a 40800-animal ED(001) tumor and biomarker study. Chem. Res. Toxicol. 22:1264-1276.
Chimploy, K., Díaz, G.D., Li, Q., Carter, O., Dashwood, W.M., Mathews, C.K., Williams, D.E., Bailey, G.S., Dashwood, R.H. 2009 E2F4 and ribonucleotide reductase mediate S-phase arrest in colon cancer cells treated with chlorophyllin. Int. J. Cancer 125:2086-2094.