Research interests explore mechanisms of chemical carcinogenesis and its modulation by dietary and environmental factors. Two important cancer preventive agents are being extensively studied — indole-3-carbinol for its promise in prevention of breast cancer, and chlorophyllin, which we are testing in a clinical trial for its potential to reduce aflatoxin-related liver cancer in China. The main experimental model is the rainbow trout, supplemented by studies with traditional rodent models. Biochemical and molecular biology approaches are employed to understand carcinogen and modulator pharmacokinetics, metabolic pathways, DNA damage and repair, mutagenic activation of oncogenes and tumor suppressor genes, cell replication and apoptosis, and how these pathways are altered by dietary treatment with chemopreventive agents. Exploratory studies are examining gene transfer to improve the utility of fish as surrogate models for cancer research. This work is carried out in collaboration with other researchers in the two NIEHS centers at OSU.
|1963||A.A., Chemistry, El Camino College|
|1965||B.S., Chemistry, University of Southern California|
|1969||Ph.D., Biochemistry, University of California at Berkeley|
|1969||Instructor in Biochemistry, University of California at Berkeley|
|1969-1971||Postdoctoral Research Associate, University of British Columbia|
|1971-1979||Lecturer, Senior Lecturer, Medical School, Department of Biochemistry, University of Otago, New Zealand|
|1979-1998||Assistant, Associate, Full Professor, Distinguished Professor, Department of Food Science and Technology, Oregon State University|
|1998-2009||Distinguished Professor, Department of Environmental and Molecular Toxicology, Oregon State University|
|1985-2002||Director, Marine and Freshwater Biomedical Sciences Center, Oregon State University|
|2002-2003||Deputy Director, Marine and Freshwater Biomedical Sciences Center, Oregon State University|
|2003-2009||Principal Investigator, Linus Pauling Institute, Oregon State University|
|2009-present||Distinguished Professor Emeritus, Department of Environmental and Molecular Toxicology, Oregon State University|
|2001||Sixth Prince Hitachi Prize in Comparative Oncology, May 2001|
|1999||Award of Merit, Foundation for Promotion of Cancer Research, Japan|
|1998||Japan Strategy of Cancer Control Lecturer, April 1998|
|1995||Distinguished Professor of Food Toxicology, Oregon State University|
|1994||Standing member, NCI Study Section reserve reviewer|
|1994||Japan Environmental Mutagen Society, 1994 Plenary Lecturer|
|1994||Gary E. Costley Award for Achievement in Nutrition|
|1993||Institute of Food Technologists Certificate of Merit award|
|1991||Appointed member, NCI Metabolic Pathology Study Section|
Alpha Gamma Sigma
American Association for Cancer Research
American Association for the Advancement of Science
Phi Lambda Upsilon
Society of Toxicologists
Parasramka MA, Dashwood WM, Wang R, Abdelli A, Bailey GS, Williams DE, Ho E, Dashwood RH (2012) MicroRNA profiling of carcinogen-induced rat colon tumors and the influence of dietary spinach. Mol Nutr Food Res 56:1259-1269.
McQuistan TJ, Simonich MT, Pratt MM, Pereira CB, Hendricks JD, Dashwood RH, Williams DE, Bailey GS (2012) Cancer chemoprevention by dietary chlorophylls: a 12,000-animal dose-dose matrix biomarker and tumor study. Food Chem Toxicol 50:341-352.
Chimploy K, Día, GD, Li Q, Carter O, Dashwood WM, Mathews CK, Williams DE, Bailey GS, and Dashwood RH (2009) E2F4 and ribonucleotide reductase mediate S-phase arrest in colon cancer cells treated with chlorophyllin. Int J Cancer 125:2086-2094.
Bailey GS, Reddy AP, Pereira CB, Harttig U, Baird W, Spitsbergen JM, Hendricks JD, Orner GA, Williams DE, Swenberg JA (2009) Nonlinear cancer response at ultralow dose: a 40800-animal ED(001) tumor and biomarker study. Chem Res Toxicol 22:1264-1276.
Williams DE, Orner G, Willard KD, Tilton S, Hendricks JD, Pereira C, Benninghoff AD, Bailey GS (2009) Rainbow trout (Oncorhynchus mykiss) and ultra-low dose cancer studies. Comp Biochem Physiol C Toxicol Pharmacol 149:175-181.
Castro DJ, Löhr CV, Fischer KA, Waters KM, Webb-Robertson BJ, Dashwood RH, Bailey GS, Williams DE (2009) Identifying efficacious approaches to chemoprevention with chlorophyllin, purified chlorophylls and freeze-dried spinach in a mouse model of transplacental carcinogenesis. Carcinogenesis 30:315-320.