Office: 320 Withycombe Hall
Telephone: (541) 737-1898
Fax: (541) 737-4174
Email Address: gerd.bobe@oregonstate.edu
Mailing/Express Delivery Address:
Gerd Bobe, Ph.D.
Department of Animal Sciences
112 Withycombe Hall
Corvallis, OR 97331-6702
| ANS 411/511 | Ruminant Nutrition |
American Association for Cancer Research
American Dairy Science Association
American Society of Animal Science
American Society of Nutritional Science
American Society of Preventive Oncology
Institute of Food Technologists
Society for Experimental Biology and Medicine
Invited Reviewer: Cancer Causes and Control, Cancer Epidemiology Biomarkers & Prevention, Carcinogenesis, Molecular Carcinogenesis, Nutrition and Cancer, Central European Journal of Medicine, International Journal of Dairy Science, Journal of Dairy Science, Dairy Science and Technology, Journal of Agricultural and Food Chemistry, Biochimie, American Journal for Food Technology, Biochemical Pharmacology, Food Chemistry, Research Journal of Microbiology, and American Journal of Epidemiology
This laboratory focuses on identifying biomarkers in humans and parallel animal models that are associated with colorectal and pancreatic cancer and can be modified by diet and dietary supplements, including micronutrients and polyphenols. Colorectal cancer is an important public health problem annually leading worldwide to over 0.5 million deaths and in the U.S. nearly 150,000 new cases and 50,000 deaths. Dietary change, both feasible and safe, represents a viable strategy for preventing colorectal cancer; however, dietary intervention trials often showed no protection. There is a need for biomarkers of exposure, risk, and response/efficacy to dietary interventions. Such biomarkers will provide crucial data to a) identify individuals at increased risk or early stages of colorectal carcinogenesis, b) measure compliance with dietary interventions, and c) predict individuals most likely to benefit from a long-term dietary intervention (i.e., personalized cancer prevention).
In collaborations with researchers at the National Cancer Institute, Pennsylvania State University, Ohio State University, Texas A&M University, and Tufts, we have been using prospective NCI-funded human cohort and nutrition studies and link them to USDA and Tufts food data bases to identify diets and dietary components with promise of efficacious cancer prevention, most notable flavonols. For dietary components showing efficacy, we have been identifying biomarkers of exposure, risk, and early dietary response through parallel human intervention and animal model studies in serum, feces, and tissue, most notable interleukin 6. The functional significance of the identified molecular targets in carcinogenesis will be tested using cell culture and transgenic mouse studies. The goal is to use the identified molecular targets and biomarkers in clinical trials to test the efficacy of diets and dietary supplements for cancer prevention.
Identification of molecular targets and predictive biomarkers for dietary colon cancer prevention, NIH Office of Cancer Complimentary and Alternative Medicine.
How do dietary flavonoids protect against advanced colorectal adenoma recurrence? A molecular epidemiologic study in the Polyp Prevention Trial (PPT), NIH Office of Dietary Supplements.
Hartman TJ, Albert PS, Zhang Z, Bagshaw D, Kris-Etherton PM, Ulbrecht J, Miller CK, Bobe G, Colburn NH, Lanza E. (2010) Consumption of a legume-enriched, low-glycemic index diet is associated with biomarkers of insulin resistance and inflammation among men at risk for colorectal cancer. J Nutr 140:60-67.
Zhao C, Ivanov I, Dougherty ER, Hartman TJ, Lanza E, Bobe G, Colburn NH, Lupton JR, Davidson LA, Chapkin RS. (2009) Noninvasive detection of candidate molecular biomarkers in subjects with a history of insulin resistance and colorectal adenomas. Cancer Prev Res 2:590-597.
Harris KL, Bobe G, Bourquin LD. (2009) Patulin surveillance in apple cider and juice marketed in Michigan. J Food Prot 72:1255-1261.
Bobe G, Peterson JJ, Gridley G, Hyer M, Dwyer JT, Brown LM. (2009) Flavonoid consumption and esophageal cancer among black and white men in the United States. Int J Cancer 125:1147-1154.
Kim YS, Young MR, Bobe G, Colburn NH, Milner JA. (2009) Bioactive food components, inflammatory targets, and cancer prevention. Cancer Prev Res 2:200-208.
Wang B, Bobe G, LaPres JJ, Bourquin LD. (2009) High sucrose diets promote intestinal epithelial cell proliferation and tumorigenesis in APC(Min) mice by increasing insulin and IGF-I levels. Nutr Cancer 61:81-93.
Wang B, Bobe G, LaPres JJ, Bourquin LD. (2009) Dietary carbohydrate source alters gene expression profile of intestinal epithelium in mice. Nutr Cancer 61:146-155.
Mentor-Marcel RA, Bobe G, Barrett KG, Young MR, Albert PS, Bennink MR, Lanza E, Colburn NH. (2009) Inflammation-associated serum and colon markers as indicators of dietary attenuation of colon carcinogenesis in ob/ob mice. Cancer Prev Res 2:60-69.
Bobe G, Sansbury LB, Albert PS, Cross AJ, Kahle L, Ashby J, Slattery ML, Caan B, Paskett E, Iber F, Kikendall JW, Lance P, Daston C, Marshall JR, Schatzkin A, Lanza E. (2008) Dietary flavonoids and colorectal adenoma recurrence in the Polyp Prevention Trial. Cancer Epidemiol Biomarkers Prev 17:1344-1353.
Bobe G, Barrett KG, Mentor-Marcel RA, Saffiotti U, Young MR, Colburn NH, Albert PS, Bennink MR, Lanza E. (2008) Dietary cooked navy beans and their fractions attenuate colon carcinogenesis in azoxymethane-induced ob/ob mice. Nutr Cancer 60:373-381.
Bobe G, Weinstein SJ, Albanes D, Hirvonen T, Ashby J, Taylor PR, Virtamo J, Stolzenberg-Solomon RZ. (2008) Flavonoid intake and risk of pancreatic cancer in male smokers (Finland). Cancer Epidemiol Biomarkers Prev 17:553-562.
Bobe G, Thede DJ, Ten Eyck TA, Bourquini LD. (2007) Microbial levels in Michigan apple cider and their association with manufacturing practices. J Food Prot 70:1187-1193.
Bobe G, Wang B, Seeram NP, Nair MG, Bourquin LD. (2006) Dietary anthocyanin-rich tart cherry extract inhibits intestinal tumorigenesis in APC(Min) mice fed suboptimal levels of sulindac. J Agric Food Chem 54:9322-9328.
