Office: 373 Linus Pauling Science Center
Telephone: (541) 737-1898
Fax: (541) 737-5077
Email Address: email@example.com
Mailing/Express Delivery Address:
Gerd Bobe, Ph.D.
Linus Pauling Institute
Oregon State University
307 Linus Pauling Science Center
Corvallis, OR 97331
This laboratory focuses on identifying biomarkers in humans and parallel animal models that are associated with colorectal and pancreatic cancer and can be modified by diet and dietary supplements, including micronutrients and polyphenols. Colorectal cancer is an important public health problem annually leading worldwide to over 0.5 million deaths and in the U.S. nearly 150,000 new cases and 50,000 deaths. Dietary change, both feasible and safe, represents a viable strategy for preventing colorectal cancer; however, dietary intervention trials often showed no protection. There is a need for biomarkers of exposure, risk, and response/efficacy to dietary interventions. Such biomarkers will provide crucial data to a) identify individuals at increased risk or early stages of colorectal carcinogenesis, b) measure compliance with dietary interventions, and c) predict individuals most likely to benefit from a long-term dietary intervention (i.e., personalized cancer prevention).
In collaborations with researchers at the National Cancer Institute, Pennsylvania State University, Ohio State University, Texas A&M University, and Tufts, we have been using prospective NCI-funded human cohort and nutrition studies and link them to USDA and Tufts food data bases to identify diets and dietary components with promise of efficacious cancer prevention, most notable flavonols. For dietary components showing efficacy, we have been identifying biomarkers of exposure, risk, and early dietary response through parallel human intervention and animal model studies in serum, feces, and tissue, most notable interleukin 6. The functional significance of the identified molecular targets in carcinogenesis will be tested using cell culture and transgenic mouse studies. The goal is to use the identified molecular targets and biomarkers in clinical trials to test the efficacy of diets and dietary supplements for cancer prevention.
|1997||M.S., Nutritional Physiology and Animal Breeding, Minor in Statistics, Iowa State University|
|2002||Ph.D., Animal Nutrition, Minor in Statistics, Iowa State University|
|2006||M.P.H., Public Health Nutrition, Johns Hopkins Bloomberg School of Public Health|
|1992-2002||Graduate Research or Teaching Assistant, Departments of Animal Science, Biology, Biochemistry, Iowa State University, Ames, IA|
|2003-2005||Visiting Research Associate, Department of Food Science and Human Nutrition, National Food Safety and Toxicology Center, Michigan State University, East Lansing, MI|
|2005-2009||Cancer Prevention Fellow, Office of Preventive Oncology, Laboratory of Cancer Prevention, National Cancer Institute, Bethesda, MD|
|2009||Cancer Research Training Award Fellow, Laboratory of Cancer Prevention, National Cancer Institute, Frederick, MD|
|2009-present||Assistant Professor, Department of Animal Sciences
Principal Investigator, Linus Pauling Institute
Adjunct Faculty, Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR
|2004||Recipient of the Richard M. Hoyt Award for Graduate Student Research from the National Milk Producers Fed.|
|2005/2009||Recipient of the Cancer Research Training Award from the NCI's Cancer Prevention Fellowship Program|
|2006||Member of Delta Omega, Honorary Society for Public Health|
|2007/2009||Recipient of the Aflac Scholar-in-Training Award from American Association for Cancer Research (AACR)|
|2008||Recipient of the Cancer Prevention Training Merit Award from NCI|
American Association for Cancer Research
American Dairy Science Association
American Society of Animal Science
American Society of Nutritional Science
American Society of Preventive Oncology
Institute of Food Technologists
Society for Experimental Biology and Medicine
Society for Nutrition Education and Behavior
Identification of molecular targets and predictive biomarkers for dietary colon cancer prevention, NIH Office of Cancer Complimentary and Alternative Medicine.
How do dietary flavonoids protect against advanced colorectal adenoma recurrence? A molecular epidemiologic study in the Polyp Prevention Trial (PPT), NIH Office of Dietary Supplements.
Saud SM, Young MR, Jones-Hall YL, Ileva L, Evbuomwan MO, Wise J, Colburn NH, Kim YS, Bobe G. (2013) Chemopreventive activity of plant flavonoid isorhamnetin in colorectal cancer is mediated by oncogenic Src and ß-catenin. Cancer Res. 73:5473-5484.
Moustafa ME, Carlson BA, Anver MR, Bobe G, Zhong N, Ward JM, Perella CM, Hoffmann VJ, Rogers K, Combs GF Jr, Schweizer U, Merlino G, Gladyshev VN, Hatfield DL. (2013) Selenium and selenoprotein deficiencies induce widespread pyogranuloma formation in mice, while high levels of dietary selenium decrease liver tumor size driven by TGFα. PLoS One. 8:e57389.
Arem H, Bobe G, Sampson J, Subar AF, Park Y, Risch H, Hollenbeck A, Mayne ST, Stolzenberg-Solomon RZ. (2013) Flavonoid intake and risk of pancreatic cancer in the National Institutes of Health-AARP Diet and Health Study Cohort. Br J Cancer. 10:1168-1172.
Mentor-Marcel RA, Bobe G, Sardo C, Wang LS, Kuo CT, Stoner G, Colburn NH. (2012) Plasma cytokines as potential response indicators to dietary freeze-dried black raspberries in colorectal cancer patients. Nutr Cancer. 64:820-825.
Bobe G, Murphy G, Albert PS, Sansbury LB, Lanza E, Schatzkin A, Cross AJ. (2012) Dietary lignan and proanthocyanidin consumption and colorectal adenoma recurrence in the Polyp Prevention Trial. Int J Cancer. 130:1649-1659.
Bobe G, Lanza E, Albert PS, Sansbury LB, Schatzkin A, Cross AJ. (2012) Dietary lignan and proanthocyanidin consumption and colorectal adenoma recurrence in the Polyp Prevention Trial. Int J Cancer Prev. 130:1649-1655.
Bobe G, Murphy G, Albert PS, Sansbury LB, Young MR, Lanza E, Schatzkin A, Colburn NH, Cross AJ. (2011) Do interleukin polymorphisms play a role in the prevention of colorectal adenoma recurrence by dietary flavonols? Eur J Cancer Prev. 20:86-95.
Zhang Z, Lanza E, Kris-Etherton PM, Colburn NH, Bagshaw D, Rovine MJ, Ulbrecht JS, Bobe G, Chapkin RS, Hartman TJ. (2010) A high legume low glycemic index diet improves serum lipid profiles in men. Lipids. 45:765-775.
Bobe G, Murphy G, Rogers CJ, Hance KW, Albert PS, Laiyemo AO, Sansbury LB, Lanza E, Schatzkin A, Cross AJ. (2010) Serum adiponectin, leptin, C-peptide, homocysteine, and colorectal adenoma recurrence in the Polyp Prevention Trial. Cancer Epid Bio Prev. 19:1441-1452.
Bobe G, Albert PS, Sansbury LB, Lanza E, Schatzkin A, Colburn NH, Cross AJ. (2010) Interleukin-6 as a potential indicator for prevention of high-risk adenoma recurrence by dietary flavonols in the polyp prevention trial. Cancer Prev Res (Phila). 3:764-775.
Gamero AM, Young MR, Mentor-Marcel R Bobe G, Scarzello AJ, Wise J, Colburn NH. (2010) STAT2 contributes to promotion of colorectal and skin carcinogenesis. Cancer Prev Res (Phila). 3:495-504.
Camalier CE, Young MR, Bobe G, Perella CM, Colburn NH, Beck GR Jr. (2010) Elevated phosphate activates N-ras and promotes cell transformation and skin tumorigenesis. Cancer Prev Res (Phila). 3:359-370.
Hartman TJ, Albert PS, Zhang Z, Bagshaw D, Kris-Etherton PM, Ulbrecht J, Miller CK, Bobe G, Colburn NH, Lanza E. (2010) Consumption of a legume-enriched, low-glycemic index diet is associated with biomarkers of insulin resistance and inflammation among men at risk for colorectal cancer. J Nutr. 140:60-67.
Zhao C, Ivanov I, Dougherty ER, Hartman TJ, Lanza E, Bobe G, Colburn NH, Lupton JR, Davidson LA, Chapkin RS. (2009) Noninvasive detection of candidate molecular biomarkers in subjects with a history of insulin resistance and colorectal adenomas. Cancer Prev Res. 2:590-597.
Bobe G, Peterson JJ, Gridley G, Hyer M, Dwyer JT, Brown LM. (2009) Flavonoid consumption and esophageal cancer among black and white men in the United States. Int J Cancer. 125:1147-1154.
Kim YS, Young MR, Bobe G, Colburn NH, Milner JA. (2009) Bioactive food components, inflammatory targets, and cancer prevention. Cancer Prev Res. 2:200-208.
Wang B, Bobe G, LaPres JJ, Bourquin LD. (2009) High sucrose diets promote intestinal epithelial cell proliferation and tumorigenesis in APC(Min) mice by increasing insulin and IGF-I levels. Nutr Cancer. 61:81-93.
Wang B, Bobe G, LaPres JJ, Bourquin LD. (2009) Dietary carbohydrate source alters gene expression profile of intestinal epithelium in mice. Nutr Cancer. 61:146-155.
Mentor-Marcel RA, Bobe G, Barrett KG, Young MR, Albert PS, Bennink MR, Lanza E, Colburn NH. (2009) Inflammation-associated serum and colon markers as indicators of dietary attenuation of colon carcinogenesis in ob/ob mice. Cancer Prev Res. 2:60-69.