Office: 503 Weniger Hall
Telephone: (541) 737-5086
Fax: (541) 737-5077
Email Address: rod.dashwood@oregonstate.edu
Mailing/Express Delivery Address:
Roderick Dashwood, Ph.D.
Linus Pauling Institute
Oregon State University
571 Weniger Hall
Corvallis, OR 97331-6512
| 1986-1990 | Post-doctoral Associate, Department of Food Science and Technology, Oregon State University (OSU) |
| 1990-1995 | Assistant Professor, Department of Environmental Biochemistry, University of Hawaii (UH) |
| 1995-1998 | Associate Professor, Department of Environmental Biochemistry, UH |
| 1997-1998 | Foreign Research Fellow, National Cancer Center Research Institute, Tokyo, Japan |
| 1998-2002 | Principal Investigator, Linus Pauling Institute,
OSU Associate Professor, Environmental and Molecular Toxicology, OSU Member of the Carcinogenesis Core, NIEHS Environmental Health Sciences Center, OSU |
| 1998-present | Member of the NIEHS
Environmental Health Sciences Center, OSU Adjunct Professor, Department of Biochemistry and Biophysics, OSU Adjunct Professor, Molecular and Cellular Biology Program, OSU |
| 2001-present | Director, Cancer Chemoprotection Program, Linus Pauling Institute, OSU |
| 2002-present | Principal Investigator, Linus Pauling Institute,
OSU Professor of Environmental and Molecular Toxicology, OSU |
| 1995 | Regents' Medal for Excellence in Teaching |
| 1997 | Regents' Medal for Excellence in Research |
| 1997 | Foundation for Promotion of Cancer Research Fellowship, Tokyo, Japan |
Mutation Research Reviews
Pharmacological Research
Clinical Epigenetics
Site Visit Team, "Tea and Cancer Prevention" (P01), Rutgers University
Grant Review, Subcommittee E - ad hoc
Grant Review, National Cancer Institute (NCI)/National Center for
Complementary and Alternative Medicine (NCCAM) - ad hoc
Grant Review, Cancer Etiology Study Section - ad hoc
Expert Panel, NIEHS/National Toxicology Program (NTP) Report
on Carcinogens
National Advisory Council for Complementary and Alternative Medicine - ad
hoc
Grant Review, Chemo/Dietary Prevention (CDP) Study Section - ad hoc
Session Chair,
Session Chair, Organizing Committee, LPI Conference on Diet and Optimum Health, Portland, Oregon (2007)
Co-organizer, Symposium on "Tea and Health", 3rd International Conference on Polyphenols and Health, Kyoto, Japan (2007)
Session Chair, 38th International Symposium of the Princess Takamatsu Cancer Research Fund, "New Challenges and Control for Colon Cancer", Tokyo, Japan (2007)
Symposium Chair, 2nd International Conference on Translational Cancer Research, Lonavala, India (2007)
Scientific Advisory Committee, International Conference on Mechanisms of Antimutagenesis and Anticarcinogenesis 2007, Jeju Island, South Korea (2007)
Session Chair and member of International Scientific Committee, 4th International Niigata Symposium on Diet and Health, "Integrative functions of diet in anti-aging and cancer prevention", Niigata City, Japan (2008)
Co-chair, LPI "Diet and Optimum Health Conference" (2009)
Session chair, SFRR Asia, Langkawi, Malaysia (2009)
This lab examines genetic and epigenetic mechanisms of colorectal cancer development. We use human colon cancer cells and whole animal approaches, including transgenic models, to study mutational events in oncogenes and tumor suppressors (e.g., K-ras, beta-catenin, APC), and the influence of dietary chemopreventive agents. Our epigenetic work focuses on dietary phytochemicals as histone deacetylase (HDAC) inhibitors. Sulforaphane from broccoli, garlic organosulfur and organoselenium compounds, and a short-chain fatty acid derived from gut fermentation of dietary fiber (butyrate) inhibit HDAC activity in cancer cells, and trigger growth arrest/apoptosis. HDAC inhibition and histone acetylation also occurred in peripheral blood mononuclear cells from healthy human volunteers who consumed a single serving of broccoli sprouts (R.H. Dashwood and E. Ho (2007) Semin Cancer Biol 17, 363-369). We are now interested in translating this work into human subjects undergoing screening colonoscopies.
Modulation of Colon Carcinogenesis by Chlorophyllin, National Cancer Institute, NIH (R01 grant CA065525)
Beta-Catenin Pathway and Chemoprevention by Tea, National Cancer Institute, NIH (PI and Leader of Project 3 in Program Project Grant P01 CA090890)
Dietary HDAC Inhibitors in Colon Cancer Prevention, National Cancer Institute, NIH (R01 grant CA122959)
Dashwood RH and Ho E (2008) Dietary agents as histone deacetylase inhibitors: sulforaphane and structurally-related isothiocyanates. Nutr Rev, 66, S36-S38.
Delage B and Dashwood RH (2008) Dietary manipulation of histone structure and function. Ann Rev Nutr 28, 347-366.
Castro DJ, Yu Z, Löhr CV, Pereira CB, Giovanini J, Fischer KA, Orner GA, Dashwood RH and Williams DE (2008) Chemoprevention of dibenzo[a,l]pyrene transplacental carcinogenesis in mice born to mothers administered green tea: primary role of caffeine. Carcinogenesis 29, 1581-1586.
Wang R, Dashwood WM, Löhr CV, Fischer KA, Nakagama H, Williams DE and Dashwood RH (2008) Beta-catenin is strongly elevated in rat colonic mucosa following short-term intermittent treatment with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and a high-fat diet. Cancer Sci 99, 1754-1759.
Nian H, Delage B, Pinto JT and Dashwood RH (2008) Allyl mercaptan, a garlic-derived organosulfur compound, inhibits histone deacetylase and enhances Sp3 binding on the P21WAF1 promoter. Carcinogenesis 29, 1816-1824.
Ashktorab H, Dashwood RH, Dashwood WM, Zaidi SI, Hewitt SM, Green WR, Lee E, Nouraie R, Malekzadeh R and Smoot DT (2008) H. pylori-induced apoptosis in human gastric cancer cells mediated via the release of AIF from mitochondria. Helicobacter 13, 506-517.
Clarke JD, Dashwood RH and Ho E (2008) Multi-targeted prevention of cancer by sulforaphane. Cancer Lett 269, 291-304.
Wang R, Dashwood WM, Löhr CV, Fischer KA, Pereira CB, Louderback M, Nakagama H, Bailey GS, Williams DE and Dashwood RH (2008) Protective versus promotional effects of white tea and caffeine on PhIP-induced tumorigenesis and beta-catenin expression in the rat. Carcinogenesis 29, 834-839.
Simonich MT, McQuistan T, Jubert C, Pereira C, Hendricks JD, Schimerlik M, Zhu B, Dashwood RH, Williams DE and Bailey GS (2008) Low-dose dietary chlorophyll inhibits multi-organ carcinogenesis in the rainbow trout. Food Chem Toxicol 46, 1014-1024.
Castro DJ, Löhr CV, Fischer KA, Waters KM, Webb-Robertson BA, Dashwood RH, Bailey GS and Williams DE (2008) Identifying efficacious approaches to chemoprevention with chlorophyllin, purified chlorophylls, and freeze-dried spinach in a mouse model of transplacental carcinogenesis. Carcinogenesis 30, 315-320.
Ashktorab H, Belgrave H, Hosseinkhah F, Brim H, Nouraie M, Takkikto M, Hewitt S, Lee EL, Dashwood RH and Smoot D (2009) Global histone H4 acetylation and HDAC2 expression in colon adenoma and carcinoma. Digest Disease Sci 54, 2109-2117.
Hasaniya H, Razzuk AM, Premaratne S, Zhang W, Abdul-Ghani AA, Siera M, Dashwood RH, Eklof B, Tinsley L and McNamara JJ (2009) Ischemia-reperfusion injury in the lung: quantitation using electron microscopy. Vasc Endovasc Surg 43, 107-177.
Nian H, Delage B, Ho E and Dashwood RH (2009) Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides: studies with sulforaphane and garlic organosulfur compounds. Environ Mol Mutagen 50, 213-221.
Li Q, Löhr CV, and Dashwood RH (2009) Activator protein 2alpha suppresses intestinal tumorigenesis in the Apcmin mouse. Cancer Lett 283, 36-42.
Nian H, Bisson WH, Dashwood WM, Pinto JT, and Dashwood RH (2009) α-Keto acid metabolites of organoselenium compounds inhibit histone deacetylase activity in human colon cancer cells. Carcinogenesis 30, 1416-1423.
Lee J, Nian H, Cooper A, Sinha R, Dai J, Bisson WH, Dashwood RH, and Pinto JT (2009) α-Keto acid metabolites of naturally-occurring organoselenium compounds as inhibitors of histone deacetylase in human prostate cancer cells. Cancer Prev Res 2, 683-693.
Chimploy K, Díaz GD, Li Q, Carter O, Dashwood WM, Mathews CK, Williams DE, Bailey GS, and Dashwood RH (2009) E2F4 and ribonucleotide reductase mediate S-phase arrest in colon cancer cells treated with chlorophyllin. Int J Cancer 125, 2086-2094.
Larsen C and Dashwood RH (2009) Suppression of Met activation in human colon cancer cells treated with (-)-epigallocatechin-3-gallate: minor role of hydrogen peroxide. Biochem Biophys Res Commun 389, 527-530.
Ho E, Clarke JD, and Dashwood RH (2009) Dietary sulforaphane, a histone deacetylase inhibitor for cancer prevention. J Nutr [Epub ahead of print].
Larsen CA, Bisson WH, and Dashwood RH (2009) Tea catechins inhibit hepatocyte growth factor receptor (MET kinase) activity in human colon cancer cells: kinetic and molecular docking studies. J Med Chem [Epub ahead of print].
