Office: 503 Weniger Hall
Telephone: (541) 737-5086
Fax: (541) 737-5077
Email Address: rod.dashwood@oregonstate.edu
Mailing/Express Delivery Address:
Roderick Dashwood, Ph.D.
Linus Pauling Institute
Oregon State University
571 Weniger Hall
Corvallis, OR 97331-6512
| 1986-1990 | Post-doctoral Associate, Department of Food Science and Technology, Oregon State University (OSU) |
| 1990-1995 | Assistant Professor, Department of Environmental Biochemistry, University of Hawaii (UH) |
| 1995-1998 | Associate Professor, Department of Environmental Biochemistry, UH |
| 1997-1998 | Foreign Research Fellow, National Cancer Center Research Institute, Tokyo, Japan |
| 1998-2002 | Principal Investigator, Linus Pauling Institute,
OSU Associate Professor, Environmental and Molecular Toxicology, OSU Member of the Carcinogenesis Core, NIEHS Environmental Health Sciences Center, OSU |
| 1998-present | Member of the Carcinogenesis Core, NIEHS
Environmental Health Sciences Center, OSU Adjunct Professor, Department of Biochemistry and Biophysics, OSU Adjunct Professor, Molecular and Cellular Biology Program, OSU |
| 2001-present | Director, Cancer Chemoprotection Program, Linus Pauling Institute, OSU |
| 2002-present | Principal Investigator, Linus Pauling Institute,
OSU Professor of Environmental and Molecular Toxicology, OSU |
| 2004-present | Leader, Environmental Mutagenesis and Carcinogenesis Core, EHSC, OSU |
| 1995 | Regents' Medal for Excellence in Teaching |
| 1997 | Regents' Medal for Excellence in Research |
| 1997 | Foundation for Promotion of Cancer Research Fellowship, Tokyo, Japan |
Mutation Research Reviews
"Fundamental and Molecular Mechanisms of Mutagenesis: Fish and Fish Transgenics in Laboratory and Field Genotoxicology Studies", Mutation Research Special Issue 399 (1998) 123-268, edited by R.H. Dashwood and G.S. Bailey.
Site Visit Team, "Tea and Cancer Prevention" (P01), Rutgers University
Grant Review, Subcommittee E - ad hoc
Grant Review, National Cancer Institute (NCI)/National Center for
Complementary and Alternative Medicine (NCCAM) - ad hoc
Grant Review, Cancer Etiology Study Section - ad hoc
Expert Panel, NIEHS/National Toxicology Program (NTP) Report
on Carcinogens
National Advisory Council for Complementary and Alternative Medicine - ad
hoc
Session Chair,
4th International Conference on Mechanisms of Antimutagenesis and Anticarcinogenesis,
Banff, Canada (1994)
Meeting Organizer, USDA
Western Region Meeting, Beneficial and Adverse Effects of Natural Dietary
Chemicals on Human Health and Food Safety, Honolulu, HI (1995)
Session Chair,
27th International Symposium of the Princess Takamatsu Cancer Research
Fund, Tokyo, Japan (1996)
Session Co-chair, Antimutagenesis/Chemoprevention,
Environmental Mutagen Society, San Diego, CA (2001)
Session Chair,
8th International Conference on Environmental Mutagens, Shizuoka, Japan
(2001)
Session Co-chair,
LPI Conference on
Diet and Optimum Health, Portland, OR (2003)
Session Chair, Impact
of the Environment on Colon Cancer, Miami, FL (2003)
Session Co-chair, LPI
Conference on Diet and Optimum Health, Portland, OR (2005)
Symposium Chair, 9th
International Conference on Environmental Mutagens, San Francisco, CA
(2005)
Session Chair, UPM 75th Anniversary Conference, Cancer Prevention in the 21st Century, Kuala Lumpur, Malaysia (2006)
Session Chair, Organizing Committee, LPI Conference on Diet and Optimum Health, Portland, Oregon (2007)
Organizer and co-chair, Symposium co-organizer "Tea and Health", 3rd International Conference on Polyphenols and Health, Kyoto, Japan (2007)
The research program in my laboratory seeks to improve our understanding of the molecular and biochemical events associated with the development of colorectal cancer (CRC). Family history can be an important consideration in some individuals, and the study of such diseases as familial adenomatous polyposis (FAP) has provided insights into the genes that play a role in the development of CRC. These include oncogenes such as Ki-ras and Ctnnb1 (beta-catenin) and tumor suppressor genes such as APC, as well as genes associated with DNA repair mechanisms. Diet and lifestyle factors (such as regular exercise) also impact in a major way on CRC.
To gain better insight into these risk factors, we use in vitro and whole animal approaches, including transgenic models of CRC. Results to date suggest that chlorophylls (in green, leafy vegetables) and tea polyphenols might be effective in reducing the risk from CRC. Sulforaphane (from broccoli), allyl compounds (from garlic), and various other dietary phytochemicals are also studied as histone deacetylase (HDAC) inhibitors. HDAC inhibitors are receiving increasing interest due to their potential to act as cancer chemopreventive as well as chemotherapeutic agents. Protection during later stages of CRC might involve epigenetic changes in the ‘histone code’, such as alterations in specific acetylated lysine residues (see the article in the Spring/Summer 2004 Research Report).
Modulation of Colon Carcinogenesis by Chlorophyllin, National Cancer Institute, NIH (grant CA065525)
Beta-Catenin Pathway and Chemoprevention by Tea, National Cancer Institute, NIH (PI and Leader of Project 3 in Program Project Grant P01 CA090890)
Wang, R., Dashwood, W.M., Lohr, C.V., Fischer, K.A., Pereira, C.B., Louderback, M., Nakagama, H., Bailey, G.S., Williams, D.E., and Dashwood, R.H. (2008) Protective versus promotional effects of white tea and caffeine on PhIP-induced tumorigenesis and beta-catenin expression in the rat. Carcinogenesis, Feb 17, [Epub ahead of print] PMID: 18283038.
Simonich, M.T., McQuistan, T., Jubert, C., Pereira, C., Hendricks, J.D., Schimerlik, M., Zhu, B., Dashwood, R.H., Williams, D.E., and Bailey, G.S. (2008) Low-dose dietary chlorophyll inhibits multi-organ carcinogenesis in the rainbow trout. Food Chem. Toxicol. 46, 1014-1024.
Dashwood, R.H. and Ho, E. (2007) Dietary histone deacetylase inhibitors: From cells to mice to man. Seminars in Cancer Biology 17, 363-369.
Li, Q., Dashwood, W.-M., Zhong, X., Nakagama, H., and Dashwood, R.H. (2007) Bcl-2 over-expression in PhIP-induced colon tumors: cloning of the rat Bcl-2 promoter and characterization of a pathway involving beta-catenin, c-Myc and E2F1. Oncogene 26, 6194-6202.
Dashwood, R.H. (2007) Frontiers in polyphenols and cancer prevention. J. Nutr. 137, 267S-269S.
Myzak, M.C., Tong, P., Dashwood, W.M., Dashwood, R.H., and Ho, E. (2007) Sulforaphane retards the growth of human PC-3 prostate cancer xenografts and inhibits HDAC activity in human subjects. Exp. Biol. Med. 232, 227-234.
Carter, O., Dashwood, R.H., Wang, R., Dashwood, W.M., Orner, G.A., Fischer, K., Löhr, C.V., Pereira, C., Bailey, G.S., and Williams, D.E. (2007) Comparison of white tea, green tea, epigallocatechin-3-gallate and caffeine as inhibitors of PhIP-induced colonic aberrant crypts. Nutr. Cancer 58, 60-65.
Simonich, M.T., Egner, P., Roebuck, B.D., Orner, G.A., Jubert, C., Pereira, C., Groopman, J.D., Kensler, T.W., Dashwood, R.H., Williams, D.E., and Bailey, G.S. (2007) Natural chlorophyll inhibits aflatoxin B1-induced multi-organ carcinogenesis in the rat. Carcinogenesis 28, 1294-1302.
Higdon, J.V., Delage, B., Williams, D.E., and Dashwood, R.H. (2007) Cruciferous vegetables and human cancer risk. Pharmacol. Res. 55, 224-236.
Myzak, M.C. and Dashwood, R.H. (2006) Chemoprotection by sulforaphane: Keep one eye beyond Keap1. Cancer Lett. 233, 208-218.
Dashwood, R.H., Myzak, M.C. and Ho, E. (2006) Dietary HDAC inhibitors: time to rethink weak ligands in cancer chemoprevention? Carcinogenesis 27, 344-349.
Myzak, M.C., Hardin, K., Wang, R., Dashwood, R.H. and Ho, E. (2006) Sulforaphane inhibits histone deacetylase activity in BPH-1, LnCaP, and PC-3 prostate epithelial cells. Carcinogenesis 27, 811-819.
Myzak, M.C. and Dashwood, R.H. (2006) Histone deacetylases as targets for dietary cancer preventive agents: lessons learned with butyrate, diallyl disulfide and sulforaphane. Curr. Drug Targets 7, 443-452.
Orner, G.A., Roebuck, B.D., Dashwood, R.H. and Bailey, G.S. (2006) Post-initiation chlorophyllin exposure does not modulate aflatoxin-induced foci in the liver and colon of rats. J. Carcinog. 5, 1-6.
Yu, Z., Loehr, C.V., Fischer, K.A., Louderback, M.A., Krueger, S.K., Dashwood, R.H., Kerkvliet, N.I., Pereira, C.B., Jennings-Gee, J.E., Dance, S.T., Miller, M.S., Bailey, G.S. and Williams, D.E. (2006) In utero exposure of mice to dibenzo[a,l]pyrene produces lymphoma in the offspring: role of the aryl hydrocarbon receptor. Cancer Res. 66, 755-762.
Myzak, M.C., Dashwood, W.M., Orner, G.A., Ho, E. and Dashwood, R.H. (2006) Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apcmin mice. FASEB J. 20, 506-508.
Myzak, M.C., Ho, E. and Dashwood, R.H. (2006) Dietary agents as histone deacetylase inhibitors. Mol. Carcinog. 45, 443-446.
Cope, R.B, Loehr, C., Dashwood, R. and Kerkvliet, N. (2006) Ultraviolet radiation-induced non-melanoma skin cancer in the Crl:SHK:hr-1 hairless mouse: augmentation of tumor multiplicity by chlorophyllin and protection by indole-3-carbinol. Photochem. Photobiol. Sci. 5, 499-507.
Dashwood, R.H. (2006) Xenobiotic metabolism relevance to cancer. J. Nutr. 136, 2681S-2682S.
Wang, R., Dashwood, W.M., Bailey, G.S., Williams, D.E. and Dashwood, R.H. (2006) Tumors from rats treated with 1,2-dimethylhydrazine plus chlorophyllin or indole-3-carbinol contain transcriptional changes in beta-catenin that are independent of beta-catenin mutation status. Mutat. Res. 601, 11-18.
Kwon, D., Yoon, S., Carter, O., Bailey, G.S. and Dashwood, R.H. (2006) Antioxidant and antigenotoxic activities of Angelica keiskei, Oenanthe javanica and Brassica oleracea in the Salmonella mutagenicity assay and in HCT116 human colon cancer cells. Biofactors 26, 231-244.
