Office: 479 Linus Pauling Science Center
Telephone: (541) 737-5086
Fax: (541) 737-5077
Email Address: rod.dashwood@oregonstate.edu
Mailing/Express Delivery Address:
Roderick Dashwood, Ph.D.
Linus Pauling Institute
Oregon State University
307 Linus Pauling Science Center
Corvallis, OR 97331
| 1986-1990 | Post-doctoral Associate, Department of Food Science and Technology, Oregon State University (OSU) |
| 1990-1995 | Assistant Professor, Department of Environmental Biochemistry, University of Hawaii (UH) |
| 1995-1998 | Associate Professor, Department of Environmental Biochemistry, UH |
| 1997-1998 | Foreign Research Fellow, National Cancer Center Research Institute, Tokyo, Japan |
| 1998-2002 | Principal Investigator, Linus Pauling Institute,
OSU Associate Professor, Environmental and Molecular Toxicology, OSU Member of the Carcinogenesis Core, NIEHS Environmental Health Sciences Center, OSU |
| 1998-present | Member of the NIEHS
Environmental Health Sciences Center, OSU Adjunct Professor, Department of Biochemistry and Biophysics, OSU Adjunct Professor, Molecular and Cellular Biology Program, OSU |
| 2001-present | Director, Cancer Chemoprotection Program, Linus Pauling Institute, OSU |
| 2002-present | Principal Investigator, Linus Pauling Institute,
OSU Professor of Environmental and Molecular Toxicology, OSU |
| 1995 | Regents' Medal for Excellence in Teaching |
| 1997 | Regents' Medal for Excellence in Research |
| 1997, 2007 | Foundation for Promotion of Cancer Research Fellowship, Tokyo, Japan |
| 2011 | Helen P. Rumble Professor for Cancer Prevention |
Mutation Research Reviews
Pharmacological Research
Clinical Epigenetics
Molecular Carcinogenesis
Grant Review, National Cancer Institute (NCI)/National Center for
Complementary and Alternative Medicine (NCCAM) - ad hoc
Grant Review, Cancer Etiology Study Section - ad hoc
National Advisory Council for Complementary and Alternative Medicine - ad
hoc
Grant Review, Chemo/Dietary Prevention (CDP) Study Section - ad hoc
Grant Review, NCI P01 IRG and Subcommittee E service - ad hoc
Session Chair and member of International Scientific Committee, 4th International Niigata Symposium on Diet and Health, "Integrative functions of diet in anti-aging and cancer prevention", Niigata City, Japan (2008)
Co-chair, LPI "Diet and Optimum Health Conference" (2009)
Session chair, SFRR Asia, Langkawi, Malaysia (2009)
Session chair, International Conference on Nutrition and Physical Activity in Aging, Obesity, and Cancer, Gyenogju, S. Korea (2011)
This lab examines genetic and epigenetic mechanisms of colorectal cancer development. We use human colon cancer cells and whole animal approaches, including transgenic models, to study mutational events in oncogenes and tumor suppressors (e.g., K-ras, beta-catenin, APC), and the influence of dietary chemopreventive agents. Our epigenetic work initially focused on dietary phytochemicals and their metabolites as histone deacetylase (HDAC) inhibitors (link). Sulforaphane from broccoli, garlic organosulfur and organoselenium compounds, and a short-chain fatty acid derived from gut fermentation of dietary fiber (butyrate) inhibit HDAC activity in cancer cells, and trigger growth arrest/apoptosis. Recent work also implicated DNA methylation and microRNAs as key silencing mechanisms targeted by isolated chemopreventive agents, and by whole foods such as spinach. We are translating these findings into human subjects (link).
Mansi A. Parasramka, W. Mohaiza Dashwood, Rong Wang, Amir Abdelli, George S. Bailey, David E. Williams, Emily Ho, and Roderick H. Dashwood. (2012) MicroRNA profiling of carcinogen-induced rat colon tumors and the influence of dietary spinach. Molecular Nutrition & Food Research 56, 1259–1269.
Comparative Mechanisms of Cancer Chemoprevention, National Cancer Institute, NIH (P01 program project grant CA090890), R.H. Dashwood, Program Director and Leader of Project 3 "Chemoprevention of Colon Cancer, HDAC Inhibition and Histone Status"
Dietary HDAC Inhibitors in Colon Cancer Prevention, National Cancer Institute, NIH (R01 grant CA122959), R.H. Dashwood, Principal Investigator
Parasramka MA, Dashwood WM, Wang R, Saeed HH, Williams DE, Ho E, Dashwood RH (2012) A role for low-abundance miRNAs in colon cancer: the miR-206/Kruppel-like factor 4 (KLF4) axis. Clin Epigenetics 4:16. [Epub ahead of print].
Wang R, Löhr CV, Fischer K, Dashwood WM, Greenwood JA, Ho E, Williams DE, Ashktorab H, Dashwood MR, Dashwood RH (2012) Epigenetic inactivation of endothelin-2 and endothelin-3 in colon cancer. Int J Cancer. [Epub ahead of print].
Beaver LM, Yu TW, Sokolowski EI, Williams DE, Dashwood RH, Ho E (2012) 3,3'-Diindolylmethane, but not indole-3-carbinol, inhibits histone deacetylase activity in prostate cancer cells. Toxicol Appl Pharmacol 263:345-351.
Parasramka MA, Dashwood WM, Wang R, Abdelli A, Bailey GS, Williams DE, Ho E, Dashwood RH (2012) MicroRNA profiling of carcinogen-induced rat colon tumors and the influence of dietary spinach. Mol Nutr Food Res 56:1259-1269.
Shorey LE, Hagman AM, Williams DE, Ho E, Dashwood RH, Benninghoff AD (2012) 3,3'-Diindolylmethane induces G1 arrest and apoptosis in human acute T-cell lymphoblastic leukemia cells. PLoS One 7:e34975.
Ho E, Beaver LM, Williams DE, Dashwood RH (2011) Dietary factors and epigenetic regulation for prostate cancer prevention. Adv Nutr 2:497-510.
Hsu A, Wong CP, Williams DE, Dashwood RH, Ho E (2011) Promoter de-methylation of cyclin D2 by sulforaphane in prostate cancer cells. Clin Epigenetics 3:3.
Rajendran P, Ho E, Williams DE, Dashwood RH (2011) Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells. Clin Epigenetic 3:4.
Clarke JD, Hsu A, Williams DE, Dashwood RH, Stevens JF, Yamamoto M, Ho E (2011) Metabolism and tissue distribution of sulforaphane in Nrf2 knockout and wild-type mice. Pharm Res 28:3171-3179.
Parasramka M, Ho E, Williams DE, Dashwood RH (2011) MicroRNAs, diet, and cancer: new mechanistic insights on the epigenetic actions of phytochemicals. Mol Carcinogen 51:213-230.
Lee S-H, Richardson RL, Dashwood RH, Baek SJ (2011) Capsaicin represses transcriptional activity of beta-catenin in human colorectal cancer cells. J Nutr Biochem 23:646-655.
Li Q, Luo C, Löhr CV, Dashwood RH (2011) Activator protein-2alpha functions as a master regulator of multiple transcription factors in mouse liver. Hepatol Res 42:776-783.
Rajendran P, Delage B, Dashwood WM, Yu TW, Wuth B, Williams DE, Ho E, Dashwood RH (2011) Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3/SMRT corepressor complex dissociation/reassembly. Mol Cancer 10:68.
Rajendran P, Williams DE, Ho E, Dashwood RH (2011) Metabolism as a key to histone deacetylase inhibition. Crit Rev Biochem Mol Biol 46:181-199.
Clarke JD, Hsu A, Yu Z, Dashwood RH, Ho E (2011) Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cells. Mol Nutr Food Res 55:999-1009.
Wang R, Dashwood RH (2011) Endothelins and their receptors in cancer: Identification of therapeutic targets. Pharmacol Res 63:519-524.
Hsu A, Bruno RS, Löhr CV, Taylor AW, Dashwood RH, Bray TM, Ho E (2011) Dietary soy and tea mitigate chronic inflammation and prostate cancer via NFkappaB pathway in the Noble rat model. J Nutr Biochem 22:502-510.
Wang R, Dashwood WM, Nian H, Löhr CV, Fischer KA, Tsuchiya N, Nakagama H, Ashktorab H, Dashwood RH (2011) NADPH oxidase overexpression in human colon cancers and rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Int J Cancer 128:2581-2590.
Wang W, Jariyasopit N, Schrlau J, Jia Y, Tao S, Yu T-W, Dashwood RH, Zhang W, Wang X, Simonich SL (2011) Concentration and phytochemistry of PAHs, NPAHs, and OPAHs and toxicity of PM2.5 during the Beijing Olympic Games. Environ Sci Technol 45:6887-6895.
