skip page navigationOregon State University

LPI Faculty

Emily Ho

Principal Investigator
Linus Pauling Institute

Endowed Director,
Moore Family Center for
Whole Grain Foods, Nutrition and Preventive Health

Professor, College of Public Health and Human Sciences

Office: 214 Milam Hall

Telephone: 541-737-9559

Fax: 541-737-6914

Email Address: emily.ho@oregonstate.edu

Mailing/Express Delivery Address:
Emily Ho, Ph.D.
College of Public Health and Human Sciences
214 Milam Hall
Corvallis, OR 97331-5103


Research Interests


My research interests are in the area of antioxidants and gene expression and dietary chemoprevention strategies. I am currently interested in understanding the role of the antioxidant nutrients such as zinc in maintaining DNA integrity and cancer development. Specifically, I am concerned with the effects of zinc status on DNA damage, DNA repair and stress-response signal pathways. We are also becoming interested in the effects of zinc on the immune system, especially as we age. A large proportion of thepopulation does not eat enough zinc, especially the elderly, and hence may be at increased risk for cancer and other disorders.

Another major focus in the lab is dietary approaches for prostate cancer prevention. We are investigating the molecular mechanisms by which foods such as soy, tea, and cruciferous vegetables may protect against prostate cancer.


Education


2000-2003 Postdoctoral Fellow, Nutrition, University of California, Berkeley and Children's Hospital Oakland Research Institute
2000 Ph.D., Human Nutrition, The Ohio State University
1995 B.S., Nutritional Sciences, University of Guelph, Guelph, ON, Canada

Professional Experience


2012-present Endowed Director, Moore Family Center for Whole Grain Foods, Nutrition and Preventive Health
2008-present Associate Professor, School of Biological and Population Health Sciences, Oregon State University
2005-present Principal Investigator, Linus Pauling Institute, Oregon State University
2004-present Clinical Assistant Professor, Department of Medicine, Endocrinology & Clinical Nutrition, Oregon Health & Science University, Portland, OR
2004-present Assistant Professor, Nutrition and Exercise Sciences, Oregon State University
2003-2005 Affiliate Scientist, Linus Pauling Institute, Oregon State University
1995-2000 Graduate Research and Teaching Associate, The Ohio State University, Columbus, OH

Awards and Honors


2007 Phi Kappa Phi- Emerging Scholar Award, Linus Pauling Institute
2005 Finalist-ILSI-Future Leader Award
2005 Junior Faculty Travel Award- American Urological Association
2004 Junior Investigator Award- FASEB Summer Trace Element Conference
2002 Best Paper Award in EBM journal 2001- Society for Experimental Biology and Medicine
2002 Postdoctoral Fellow-Training Grant NIH 5 T32 ES07075 'Studies of Environmental Mutagens and Carcinogens'
2000 Young Investigator Award, Outstanding Scientific Presentation, The Oxygen Society
2000 Society of Experimental Biology and Medicine Travel Award
1998 Young Investigator Award, Oxygen Club of California
1998 Graduate Research Forum, winner (oral presentation); The Ohio State University
1997 OARDC Graduate Research Award, Ohio Agriculture Research and Development Center
1997 Sigma Xi Student Research Award
1996 Young Investigator Award; The Oxygen Society

Professional Activities and Memberships


MBG-2-Grant review panel, Department of Defense Prostate Cancer Research Program, 2008
Editorial Board Member, Journal of Nutritional Biochemistry
Member, Phi Kappa Phi Society
Member, Society for Free Radical Biology and Medicine
Member, American Association for Cancer Research
Member, American Society for Nutrition

Recent Publications


Wong CP, Hsu A, Buchanan A, Palomera-Sanchez Z, Beaver LM, Houseman EA, Williams DE, Dashwood RH, Ho E. (2014) Effects of sulforaphane and 3,3'-diindolylmethane on genome-wide promoter methylation in normal prostate epithelial cells and prostate cancer cells. PLoS One 9:e86787.

Kaur P, Shorey LE, Ho E, Dashwood RH, Williams DE. (2013) The epigenome as a potential mediator of cancer and disease prevention in prenatal development. Nutr Rev 71:441-457.

Watson GW, Beaver LM, Williams DE, Dashwood RH, Ho E. (2013) Phytochemicals from cruciferous vegetables, epigenetics, and prostate cancer prevention. AAPS J 15:951-961

Rajendran P, Kidane AI, Yu TW, Dashwood WM, Bisson WH, Löhr CV, Ho E, Williams DE, Dashwood RH. (2013) HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates. Epigenetics 8:612-623.

Shorey LE, Madeen EP, Atwell LL, Ho E, Löhr CV, Pereira CB, Dashwood RH, Williams DE. (2013) Differential modulation of dibenzo[def,p]chrysene transplacental carcinogenesis: maternal diets rich in indole-3-carbinol versus sulforaphane. Toxicol Appl Pharmacol 270:60-69.

Grider A, Wickwire K, Ho E, Chung CS, King J. (2013) Dietary zinc depletion and repletion affects plasma proteins: an analysis of the plasma proteome. Biometals 26:133-140.

Meyer M, Kesic MJ, Clarke J, Ho E, Simmen RC, Diaz-Sanchez D, Noah TL, Jaspers I. (2013) Sulforaphane induces SLPI secretion in the nasal mucosa. Respir Med 107:472-475.

Liuzzi JP, Wong CP, Ho E, Tracey A. (2013) Regulation of hepatic suppressor of cytokine signaling 3 by zinc. J Nutr Biochem 24:1028-1033.

Parasramka MA, Dashwood WM, Wang R, Saeed HH, Williams DE, Ho E, Dashwood RH. (2012) A role for low-abundance miRNAs in colon cancer: the miR-206/Krüppel-like factor 4 (KLF4) axis. Clin Epigenetics 4:16.

Wong CP, Magnusson KR, Ho E. (2013) Increased inflammatory response in aged mice is associated with age-related zinc deficiency and zinc transporter dysregulation. J Nutr Biochem 24:353-359.

Wang R, Löhr CV, Fischer K, Dashwood WM, Greenwood JA, Ho E, Williams DE, Ashktorab H, Dashwood MR, Dashwood RH. (2013) Epigenetic inactivation of endothelin-2 and endothelin-3 in colon cancer. Int J Cancer 132:1004-1012.

Beaver LM, Yu TW, Sokolowski EI, Williams DE, Dashwood RH, Ho E. (2012) 3,3'-Diindolylmethane, but not indole-3-carbinol, inhibits histone deacetylase activity in prostate cancer cells. Toxicol Appl Pharmacol 263:345-351.

Parasramka MA, Dashwood WM, Wang R, Abdelli A, Bailey GS, Williams DE, Ho E, Dashwood RH. (2012) MicroRNA profiling of carcinogen-induced rat colon tumors and the influence of dietary spinach. Mol Nutr Food Res 56:1259-1269.

Shorey LE, Hagman AM, Williams DE, Ho E, Dashwood RH, Benninghoff AD. (2012) 3,3'-Diindolylmethane induces G1 arrest and apoptosis in human acute T-cell lymphoblastic leukemia cells. PLoS One 7:e34975.

Wong CP, Ho E. (2012) Zinc and its role in age-related inflammation and immune dysfunction. Mol Nutr Food Res 56:77-87.