Office: 107A Milam Hall
Email Address: firstname.lastname@example.org
Mailing/Express Delivery Address:
Donald B. Jump
College of Public Health and Human Sciences
Oregon State University
107A Milam Hall
Corvallis, OR 97331
The type and quantity of dietary fat we ingest impacts the onset and progression of chronic diseases, e.g., atherosclerosis, diabetes and obesity. Our studies focus on the impact dietary fat has on hepatic gene expression, i.e., diet-gene interactions. Over the years we have defined mechanisms by which specific dietary fats regulate gene transcription by controlling the activity or abundance of key transcription factors. These transcription factors target genes involved in hepatic carbohydrate and lipid metabolism. Since the liver plays a central role in whole body carbohydrate and lipid metabolism, our studies reveal how diet can modify liver function, which in turn affects our health and the onset of metabolic diseases.
|1980||Ph.D., Biochemistry, Georgetown University|
|1974||M.S., Biology, Rutgers University|
|1971||B.S., Biology, Delaware State College|
|2011-present||Professor, School of Biological and Population Health Sciences, Oregon State University, Corvallis, OR|
|2007-present||Principal Investigator, Linus Pauling Institute, Oregon State University, Corvallis, OR|
|2007-2011||Professor, Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR|
|1995-2007||Professor, Departments of Physiology, Biochemistry and Molecular Biology, Michigan State University, E. Lansing, MI|
|1994-2002||Associate Chair of Physiology, and Director of the Graduate Program for Physiology, Michigan State University, E. Lansing, MI|
|1992-1995||Associate Professor, Joint Appointment, Department of Biochemistry Michigan State University, MI|
|1990-1992||Associate Professor (with tenure), Department of Physiology, Michigan State University, East Lansing, MI|
|1985-1990||Assistant Professor (tenure stream), Department of Physiology, Michigan State University, East Lansing, MI|
|1982-1985||Assistant Professor, Departments of Medicine, Genetics and Cell Biology, University of Minnesota Medical School, Minneapolis, MN|
|1980-1982||Post-doctoral Fellow, Department of Medicine, Division of Endocrinology and Metabolism, University of Minnesota, Minneapolis, MN|
|1977-1980||Pre-doctoral Research Fellow, Department of Biochemistry, Georgetown University, Washington, D. C.|
|1973-1976||Research Assistant, Agricultural Chemistry Department, Oregon State University, Corvallis, OR|
|1972-1973||Research Assistant, Oncology Section, Institute for Medical Research Camden, NJ|
|2005||Osborne and Mendel Award, American Society for Nutrition|
|2003||Keynote speaker: 1st Lipidomic Congress, Paris, France|
|1999||Visiting Professor, Nutrition Council, Iowa State University, Ames, IA|
|1998||Speaker at the National Academy of Science for National Research Council, Wash., D.C.|
|1995||Jean Andrews Visiting Professor, Nutritional Science Program,University of Texas-Austin|
|1979-81||National Research Service Award (NIH-T32, 1979-1981), Univ. Minnesota|
|2005-present||American Society of Nutritional Sciences|
|1985-present||American Society of Biochemistry and Molecular Biology|
Jump DB, Tripathy S, Depner CM. (2013) Fatty Acid-regulated transcription factors in the liver. Ann Rev of Nutr 33:249-269.
Depner CM, Philbrick KA, Jump DB. (2013) Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr-/- mouse model of western diet-induced nonalcoholic steatohepatitis. J of Nutr 143:315-323.
Tripathy S, Jump DB. (2013) Elovl5 regulates the mTORC2-Akt-FOXO1 pathway by controlling hepatic cis-vaccenic acid synthesis in diet-induced obese mice. J Lipid Res 54:71-84.
Jump DB, Depner CM, Tripathy S. (2012) Omega-3 fatty acid supplementation and cardiovascular disease. J Lipid Res 53:2525-2545.
Depner CM, Torres-Gonzalez M, Tripathy S, Milne G, Jump DB. (2012) Menhaden oil decreases high-fat diet-induced markers of hepatic damage, steatosis, inflammation, and fibrosis in obese Ldlr-/- mice. J Nutr 142:1495-1503.
Lebold KM, Jump DB, Miller GW, Wright CL, Labut EM, Barton CL, Tanguay RL, Traber MG. (2011) Vitamin E deficiency decreases long-chain PUFA in zebrafish (Danio rerio). J Nutr 141:2113-2118.
Jump DB, Torres-Gonzalez M, Olson LK. (2011) Soraphen A, an inhibitor of acetyl CoA carboxylase activity, interferes with fatty acid elongation. Biochem Pharmacol 81:649-660.
Jump DB. (2011) Fatty acid regulation of hepatic lipid metabolism. Curr Opin Clin Nutr Metab Care 14:115-120.
Tripathy S, Torres-Gonzalez M, Jump DB. (2010) Elevated hepatic fatty acid elongase-5 activity corrects dietary fat-induced hyperglycemia in obese C57BL/6J mice. J Lipid Res 51:2642-2654.
Green CD, Ozguden-Akkoc CG, Wang Y, Jump DB, Olson LK. (2010) Role of fatty acid elongases in determination of de novo synthesized monounsaturated fatty acid species. J Lipid Res 51:1871-1877.
Tikhonenko M, Lydic TA, Wang Y, Chen W, Opreanu M, Sochacki A, McSorley KM, Renis RL, Kern T, Jump DB, Reid GE, Busik JV. (2010) Remodeling of retinal Fatty acids in an animal model of diabetes: a decrease in long-chain polyunsaturated fatty acids is associated with a decrease in fatty acid elongases Elovl2 and Elovl4. Diabetes 59:219-227.
Menagh PJ, Turner RT, Jump DB, Wong CP, Lowry MB, Yakar S, Rosen CJ, Iwaniec UT. (2010) Growth hormone regulates the balance between bone formation and bone marrow adiposity. J Bone Miner Res 25:757-768.
Jump DB. (2009) Mammalian fatty acid elongases. Methods Mol Biol 579:375-389.
Green CD, Jump DB, Olson LK. (2009) Elevated insulin secretion from liver X receptor-activated pancreatic beta-cells involves increased de novo lipid synthesis and triacylglyceride turnover. Endocrinology 150:2637-2645.
Jump DB. (2008) N-3 polyunsaturated fatty acid regulation of hepatic gene transcription. Curr Opin Lipidol 19:242-247.