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LPI Faculty

Donald B. Jump, Ph.D.

Principal Investigator,
Linus Pauling Institute

Director,
Nutrition Graduate Program, College of Public Health and Human Sciences

Professor,
School of Biological and Population Health Sciences

Office: 107A Milam Hall

Telephone: 541-737-4007

Fax: 541-737-6914

Email Address: donald.jump@oregonstate.edu

Mailing/Express Delivery Address:
Donald B. Jump
College of Public Health and Human Sciences
Oregon State University
107A Milam Hall
Corvallis, OR 97331


Research Interests

The type and quantity of dietary fat we ingest impacts the onset and progression of chronic diseases, e.g., atherosclerosis, diabetes and obesity. Our studies focus on the impact dietary fat has on hepatic gene expression, i.e., diet-gene interactions. Over the years we have defined mechanisms by which specific dietary fats regulate gene transcription by controlling the activity or abundance of key transcription factors. These transcription factors target genes involved in hepatic carbohydrate and lipid metabolism. Since the liver plays a central role in whole body carbohydrate and lipid metabolism, our studies reveal how diet can modify liver function, which in turn affects our health and the onset of metabolic diseases.


Education

1980 Ph.D., Biochemistry, Georgetown University
1974 M.S., Biology, Rutgers University
1971 B.S., Biology, Delaware State College

Professional Experience

2011-present Professor, School of Biological and Population Health Sciences, Oregon State University, Corvallis, OR
2007-present Principal Investigator, Linus Pauling Institute, Oregon State University, Corvallis, OR
2007-2011 Professor, Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR
1995-2007 Professor, Departments of Physiology, Biochemistry and Molecular Biology, Michigan State University, E. Lansing, MI
1994-2002 Associate Chair of Physiology, and Director of the Graduate Program for Physiology, Michigan State University, E. Lansing, MI
1992-1995 Associate Professor, Joint Appointment, Department of Biochemistry Michigan State University, MI
1990-1992 Associate Professor (with tenure), Department of Physiology, Michigan State University, East Lansing, MI
1985-1990 Assistant Professor (tenure stream), Department of Physiology, Michigan State University, East Lansing, MI
1982-1985 Assistant Professor, Departments of Medicine, Genetics and Cell Biology, University of Minnesota Medical School, Minneapolis, MN
1980-1982 Post-doctoral Fellow, Department of Medicine, Division of Endocrinology and Metabolism, University of Minnesota, Minneapolis, MN
1977-1980 Pre-doctoral Research Fellow, Department of Biochemistry, Georgetown University, Washington, D. C.
1973-1976 Research Assistant, Agricultural Chemistry Department, Oregon State University, Corvallis, OR
1972-1973 Research Assistant, Oncology Section, Institute for Medical Research Camden, NJ

Professional Awards

2005 Osborne and Mendel Award, American Society for Nutrition
2003 Keynote speaker: 1st Lipidomic Congress, Paris, France
1999 Visiting Professor, Nutrition Council, Iowa State University, Ames, IA
1998 Speaker at the National Academy of Science for National Research Council, Wash., D.C.
1995 Jean Andrews Visiting Professor, Nutritional Science Program,University of Texas-Austin
1979-81 National Research Service Award (NIH-T32, 1979-1981), Univ. Minnesota

Professional Activities and Memberships

2005-present American Society of Nutritional Sciences
1985-present American Society of Biochemistry and Molecular Biology

Recent Publications

Lebold KM, Kirkwood JS, Taylor AW, Choi J, Barton CL, Miller GW, Du JL, Jump DB, Stevens JF, Tanguay RL, Traber MG. (2013) Novel liquid chromatography-mass spectrometry method shows that vitamin E deficiency depletes arachidonic and docosahexaenoic acids in zebrafish (Danio rerio) embryos. Redox Biol 2:105-113.

Depner CM, Traber MG, Bobe G, Kensicki E, Bohren KM, Milne G, Jump DB. (2013) A metabolomic analysis of omega-3 fatty acid-mediated attenuation of western diet-induced nonalcoholic steatohepatitis in LDLR-/- mice. PLoS One 8:e83756.

Jump DB, Tripathy S, Depner CM. (2013) Fatty Acid-regulated transcription factors in the liver. Ann Rev of Nutr 33:249-269.

Depner CM, Philbrick KA, Jump DB. (2013) Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr-/- mouse model of western diet-induced nonalcoholic steatohepatitis. J of Nutr 143:315-323.

Tripathy S, Jump DB. (2013) Elovl5 regulates the mTORC2-Akt-FOXO1 pathway by controlling hepatic cis-vaccenic acid synthesis in diet-induced obese mice. J Lipid Res 54:71-84.

Jump DB, Depner CM, Tripathy S. (2012) Omega-3 fatty acid supplementation and cardiovascular disease. J Lipid Res 53:2525-2545.

Depner CM, Torres-Gonzalez M, Tripathy S, Milne G, Jump DB. (2012) Menhaden oil decreases high-fat diet-induced markers of hepatic damage, steatosis, inflammation, and fibrosis in obese Ldlr-/- mice. J Nutr 142:1495-1503.

Lebold KM, Jump DB, Miller GW, Wright CL, Labut EM, Barton CL, Tanguay RL, Traber MG. (2011) Vitamin E deficiency decreases long-chain PUFA in zebrafish (Danio rerio). J Nutr 141:2113-2118.

Jump DB, Torres-Gonzalez M, Olson LK. (2011) Soraphen A, an inhibitor of acetyl CoA carboxylase activity, interferes with fatty acid elongation. Biochem Pharmacol 81:649-660.

Jump DB. (2011) Fatty acid regulation of hepatic lipid metabolism. Curr Opin Clin Nutr Metab Care 14:115-120.