Office: 459 Linus Pauling Science Center
Telephone: (541) 737-9322
Fax: (541) 737-5077
Email Address: sharon.krueger@oregonstate.edu
Mailing/Express Delivery Address:
Sharon K. Krueger, Ph.D.
Linus Pauling Institute
Oregon State University
307 Linus Pauling Science Center
Corvallis, OR 97331
| 1983 | B.S., Horticulture, University of Wisconsin-Madison |
| 1986 | M.S., Plant Breeding and Plant Genetics, University of Wisconsin-Madison |
| 1990 | Ph.D., Plant Breeding, Oregon State University |
American Association for the Advancement of Science
International Society for the Study of Xenobiotics
Pacific Northwest Association of Toxicologists
Society of Toxicology
The flavin-containing monooxygenases (FMOs) are a family of related enzymes that are poised to metabolize many of the drugs and xenobiotics that we are exposed to (by oral, inhalation or dermal exposure). Depending on the type of chemical, FMO metabolism can produce metabolites that are more or less toxic than the parent compound. Because a polymorphism exists for FMO2 in 26% of African-Americans and 5-10% of Hispanic-Americans, we hypothesize that there is potential for a distinct therapeutic response or unintended risk as a consequence of substrate exposure. Research studies to determine the relevance of FMO2 variants are underway. Lung cell lines differentially expressing FMO2 provide a platform for in vitro tests, while the Fmo2 knockout mouse under construction will allow in vivo testing of FMO2 variants. Studies of FMO structure and function are also ongoing.
NIH/NHLBI, R01 HL38650 (Co-I), Flavin-Containing Monooxygenase in Lung (2005-2008)
Celius T, Pansoy A, Matthews J, Okey AB, Henderson MC, Krueger SK, and Williams DE (2010) Flavin-containing monooxygenase-3: induction by 3-methylcholanthrene and complex regulation by xenobiotic chemicals in hepatoma cells and mouse liver. Toxicol Appl Pharmacol 247:60-69.
Krueger SK, Henderson MC, Siddens LK, VanDyke JE, Benninghoff AD, Karplus PA, Furnes B, Schlenk D, and Williams DE (2009) Characterization of sulfoxygenation and structural implications of human flavin-containing monooxygenase isoform 2 (FMO2.1) variants S195L and N413K. Drug Metab Dispos 37:1785-1791.
Castro DJ, Baird WM, Pereira CB, Giovanini J, Löhr CV, Fischer KA, Yu Z, Gonzalez FJ, Krueger SK, and Williams DE (2008) Fetal mouse Cyp1b1 and transplacental carcinogenesis from maternal exposure to dibenzo(a,l)pyrene. Cancer Prev Res 1:128-134.
Henderson MC, Siddens LK, Morré JT, Krueger SK, and Williams DE (2008) Metabolism of the anti-tuberculosis drug ethionamide by mouse and human FMO1, FMO2 and FMO3 and mouse and human lung microsomes. Toxicol Appl Pharmacol 233:420-427.
Siddens LK, Henderson MC, Vandyke JE, Williams DE, Krueger SK (2008) Characterization of mouse flavin-containing monooxygenase transcript levels in lung and liver, and activity of expressed isoforms. Biochem Pharmacol 75:570-579.
Koukouritaki SB, Poch MT, Henderson MC, Siddens LK, Krueger SK, VanDyke JE, Williams DE, Pajewski NM, Wang T and Hines RN (2007) Identification and functional analysis of human flavin-containing monooxygenase 3 (FMO3) genetic variants. J Pharmacol Exper Therap 320:266-273.
Vyas PM, Roychowdhury S, Koukouritaki SB, Hines RN, Krueger SK, Williams DE, Nauseef WM, and Svensson CK (2006) Enzyme-mediated protein haptenation of dapsone and sulfamethoxazole in human keratinocytes. - 2. Expression and role of flavin monooxygenases and peroxidases. J Pharmacol Exper Therap 319:497-505.
Yu Z, Mahadevan B, Löhr CV, Fischer KA, Louderback MA, Krueger SK, Pereira CB, Albershardt DJ, Baird WM, Bailey GS, and Williams DE (2006) Indole-3-carbinol in the maternal diet provides chemoprotection for the fetus against transplacental carcinogenesis by the polycyclic aromatic hydrocarbon, dibenzo[a,l]pyrene. Carcinogenesis 27:2116-2123.
Krueger SK, Siddens LK, Henderson MC, VanDyke JE, Karplus PA, Pereira CB, and Williams DE (2006) C-terminal truncation of rabbit flavin-containing monooxygenase isoform 2 enhances solubility. Arch Biochem Biophys 450:149-156.
Krueger SK, VanDyke JE, Hines RN and Williams DE (2006) The role of the flavin-containing monooxygenase (FMO) in the metabolism of tamoxifen and other tertiary amines. Drug Metab Reviews 38:139-147.
Yu Z, Löhr CV, Fischer KA, Louderback MA, Krueger SK, Dashwood RH, Kerkvliet NI, Pereira CB, Jennings-Gee JE, Dance ST, Miller MS, Bailey GS, and Williams DE (2006) In utero exposure of mice to dibenzo[a,l]pyrene produces lymphoma in the offspring: role of the aryl hydrocarbon receptor. Cancer Res 66:755-762.
Krueger SK, and Williams DE (2005) Mammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and role in drug metabolism. Pharmacol Therap 106:357-387.
Krueger SK, Siddens LK, Henderson MC, Andreasen EA, Tanguay RL, Pereira CB, Cabacungan ET, Hines RN, Ardlie KG, and Williams DE (2005). Haplotype and functional analysis of four flavin-containing monooxygenase isoform 2 (FMO2) polymorphisms in Hispanics. Pharmacogenetics Genomics 15:245-256.
