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Faculty




Gayle Orner, Ph.D.

Research Assistant Professor, Linus Pauling Institute

Office: 500 Weniger Hall

Telephone: (541) 737-8730

Fax: (541) 737-5077

Email Address: gayle.orner@oregonstate.edu

Mailing/Express Delivery Address:
Gayle Orner, Ph.D.
Linus Pauling Institute
Oregon State University
571 Weniger Hall
Corvallis, OR 97331-6512


Education

1984 B.S., Biology, The Pennsylvania State University
1995 Ph.D., Toxicology, Oregon State University

Professional Experience

1985-89 Biological Research Technician, Toxicology Division, Letterman Army Institute of Research, Presidio of San Francisco, CA
1989-90 Biological Research Technician/Noncommissioned Officer in Charge, Oxidative Injury Group, Division of Military Trauma Research, Letterman Army Institute of Research, Presidio of San Francisco, CA
1995-98 Postdoctoral Research Fellow, Molecular Biosciences Department, Pacific Northwest National Laboratory, Richland, WA
1998-2003 Research Associate, Linus Pauling Institute/Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR
2003-present Research Assistant Professor, Linus Pauling Institute, Oregon State University, Corvallis, OR

Awards and Grants

1984 Bachelor's Degree Conferred with Distinction
Golden Key National Honor Society
Phi Sigma Biological Honor Society
1985-90 U.S. Army Commendation Medal, 4 awards
1987 Distinguished Graduate, U.S. Army Primary Leadership Development Course
1989 U.S. Army Achievement Medal
Medical Research and Development Command Noncommissioned Officer of the Year
1990 U.S. Army National Defense Service Medal
U.S. Army Humanitarian Service Medal
1990-94 NIEHS Toxicology Training Grant Predoctoral Trainee, Oregon State University
1993 Oregon State University Graduate Student Congress, Student Poster Award
AACR Histopathology of Neoplasia Workshop Participant
Gordon Conference on Drub Metabolism, student Travel Award
Pacific Northwest Associate for Toxicology, Student Poster Award
1994 Pacific Northwest Association for Toxicology, Student Platform Award
1995 Society of Toxicology Student Travel Award
1995-98 Associate Western Universities Postdoctoral Fellowship
1997 Hanford Site Pollution Prevention Accomplishments
1998-00 NIEHS Toxicology Trianing Grant Postdoctoral Trainee, Oregon State University
2001-02 Linus Pauling Institute, Oregon State University, Pilot Project "Combined Chemoprevention of Intestinal Cancer"
2002-03 Linus Pauling Institute, Oregon State University, Pilot Project "Modulation of Intestinal Tumorigenesis in Apcmin Mice by Chlorophyllin"
2003-05 NIH/NCI Cancer Chemoprevention Research Small Grant Program (R03) "Combined Chemoprevention in Beta-Catenin Mutant Mice"
2003-05 NIH/NCI/NCCAM Developmental/Pilot Project in Cancer CAM (R21) "Combined Effects of Tea Plus NSAIDs Towards Colon Cancer"

Professional Activities and Memberships

American Association for Cancer Research (Active Member)
Environmental Mutagen Society
Women in Cancer Research
Pacific Northwest Association of Toxicologists
Society of Toxicology
International Society for the Study of Xenobiotics
American Association for Laboratory Animal Science (Technician Certification)


Recent Publications

Williams, D.E., Bailey, G.S., Reddy, A., Hendricks, J.D., Oganesian, A., Orner, G.A., Pereira, C.B., and Swenberg, J.A. (2003) The rainbow trout tumor model: Recent applications in low dose exposures to tumor initiators and promoters. Toxicol. Pathol. 31, 58-61.

Orner, G.A., Dashwood, W-M., Blum, C.A., Díaz, D., Li, Q., and Dashwood, R.H. (2003) Suppression of tumorigenesis in the Apcmin mouse: Down-regulation of beta-catenin signaling by a combination of tea plus sulindac. Carcinogenesis 24, 263-267.

Blum, C.A., Xu, M., Orner, G.A., Díaz, D., Li, Q., Dashwood, W-M., and Dashwood, R.H. (2003) Promotion versus suppression of rat colon carcinogenesis by chlorophyllin and chlorophyll: modulation of apoptosis, cell proliferation, and beta-catenin/Tcf signaling. Mutation Res. 523-524, 217-223.

Orner, G.A., Dashwood, W.M., and Dashwood, R.H. (2004) Tumor-suppressing effects of antioxidants from tea. J Nutr. 134, 3177S-3178S.

Myzak, M.C., Dashwood, W.M., Orner, G.A., Ho, E. and Dashwood, R.H. (2006) Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apcmin mice. FASEB J. 20, 506-508.

Orner, G.A., Roebuck, B.D., Dashwood, R.H. and Bailey, G.S. (2006) Post-initiation chlorophyllin exposure does not modulate aflatoxin-induced foci in the liver and colon of rats. J. Carcinog. 5, 1-6.

Tilton, S.C., Hendricks, J.D., Orner, G.A., Pereira, C.B., Bailey, G.S., and Williams, D.E. (2007) Gene expression analysis during tumor enhancement by the dietary phytochemical, 3,3'-diindolylmethane, in rainbow trout. Carcinogenesis 28, 1589-1598.

Simonich, M.T., Egner, P.A., Roebuck, B.D., Orner, G.A., Jubert, C., Pereira, C., Groopman, J.D., Kensler, T.W., Dashwood, R.H., Williams, D.E., and Bailey, G.S. (2007) Natural chlorophyll inhibits aflatoxin B1-induced multi-organ carcinogenesis in the rat. Carcinogenesis 28, 1294-1302.

Carter, O., Dashwood, R.H., Wang, R., Dashwood, W.M., Orner, G.A., Fischer, K.A., Löhr, C.V., Pereira, C.B., Bailey, G.S., and Williams, D.E. (2007) Comparison of white tea, green tea, epigallocatechin-3-gallate, and caffeine as inhibitors of PhIP-induced colonic aberrant crypts. Nutr. Cancer 58, 60-65.