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LPI Faculty

David Williams, Ph.D.

Principal Investigator,
Linus Pauling Institute

Director,
Superfund Research Program

Professor,
Department of Environmental and Molecular Toxicology

Office: 473 Linus Pauling Science Center

Telephone: 541-737-3277

Fax: 541-737-0497

Email Address: david.williams@oregonstate.edu

Mailing/Express Delivery Address:
David Williams, Ph.D.
Linus Pauling Institute
Oregon State University
307 Linus Pauling Science Center
Corvallis, OR 97331


Research Interests


My research interests are in the characterization and regulation of microsomal monooxygenase enzymes (Cytochromes P450 and Flavin-Containing Monooxygenases) active in drug metabolism and their involvement in the detoxication and/or bioactivation of drugs, xenobiotics and endogenous compounds. In addition, a major focus of current research efforts is on diet and cancer. These studies employ both trout, mouse and human cell culture models to address mechanistic questions. Currently, we are working on a model that addresses the issue of maternal diet on cancer risk for the fetus in later life


Education

1982 Ph.D., Biochemistry, Oregon State University
1981 M.S., Biochemistry, Oregon State University
1975 B.A., Biology, Reed College

Professional Experience

1998-present Principal Investigator, Linus Pauling Institute
2009-present Director, Superfund Research Program
2002-2009 Director, NIEHS Marine/Freshwater Biomedical Sciences Center, Oregon State University
1998-2001 Chief, Cancer Chemoprevention Program, Linus Pauling Institute, Oregon State University
1997-present Professor, Dept. Environmental and Molecular Toxicology, Oregon State University
2007- Interim Dept. Head, Environmental and Molecular Toxicology, Oregon State University
1995-1997 Professor, Dept. Food Sci.& Tech. and Toxicology Prog., Oregon State University
1994-2006 Director, NIEHS Toxicology Training Grant, Oregon State University
1991-2001 Deputy Director, Marine/Freshwater Biomedical Sciences Center, Oregon State University
1991-1995 Associate Professor, Dept. Food Sci. & Tech., and Toxicology Prog., Oregon State University
1987-1991 Assistant Professor, Dept. Food Sci. & Tech., and Toxicology Prog., Oregon State University
1986-1987 Assistant Professor (Sr. Res.), Department of Agricultural Chemistry, Oregon State University
1985-1986 Research Assistant Professor, Dept. Biochemistry, Medical College of Wisconsin, Milwaukee
1984-1985 Instructor, Dept. Biochemistry, Medical College of Wisconsin
1982-1984 Research Associate, Dept. Biochemistry, Medical College of Wisconsin; under the direction of Dr. Bettie Sue Masters

Awards and Honors

1996 Earl Price Award for Excellence in Research, Oregon State University College of Agricultural Sciences
Certificate of Merit for Authorship of "Potential Mechanisms for Food-Related Carcinogens and Anticarcinogens," a Scientific Status Summary, Institute of Food Technologists
1992 Gary E. Costley Award in Nutrition, Kellogs
1990 Phi Kappa Phi Honor Society Emerging Scholar Faculty Award, Oregon State University
1984-1986 Parker B. Francis Postdoctoral Fellowship in Pulmonary Research, the Puritan Bennett Foundation


Editorial Boards


Editorial Advisory Board, “An Evidence-based Approach to Dietary Phytochemicals” (2006) Thieme Medical Publishers

Associate Editor, Toxicology and Applied Pharmacology (2004-present)

Editorial Advisory Board, Toxicology and Applied Pharmacology (1998-2004)

Consulting Editor, Cell Biology and Toxicology (2000-present)


Professional Societies


American Society for Pharmacology and Experimental Therapeutics (2002-present)
Councilor, Drug Metabolism Division (2004-2007)

Secretary/Treasurer, Food Safety Specialty Section (1998-2000)

Oregon State Legislative Committee (1998-2000)

Toxicology Education Foundation (1998-1999)
Co-Chair K-12 Education Committee (1997-1998), Chair (1998-1999)
Education Committee (1997-1999)

American Chemical Society (1996-2000)

American Association for Cancer Research (1989-present)

American Society of Biochemistry and Molecular Biology (1989-1998)

Institute of Food Technologists (1988-1997)

Pacific Northwest Association of Toxicologists (1986-present)
President (1996-1997) President Elect (1995-1996), Vice President Elect (1994-1995), Secretary/Treasurer (1990-1992)

Society of Toxicology (1986-present)

International Society for the Study of Xenobiotics (1984-present)


Research Projects

Project 1 - PAH Mixtures as Carcinogens


The focus of this project is on PAH-dependent cancers of skin in adults and transplacentally, lung, liver and lymphoid tissue and the potential for chemoprevention in reducing PAH-dependent cancer mortality.


Selected Recent Publications

Siddens LK, Krueger SK, Henderson MC, Williams DE. (2014) Mammalian flavin-containing monooxygenase (FMO) as a source of hydrogen peroxide. Biochem Pharmacol [Epub ahead of print].

Wong CP, Hsu A, Buchanan A, Palomera-Sanchez Z, Beaver LM, Houseman EA, Williams DE, Dashwood RH, Ho E. (2014) Effects of sulforaphane and 3,3'-diindolylmethane on genome-wide promoter methylation in normal prostate epithelial cells and prostate cancer cells. PLoS One 9:e86787.

Watson GW, Beaver LM, Williams DE, Dashwood RH, Ho E. (2013) Phytochemicals from cruciferous vegetables, epigenetics, and prostate cancer prevention. AAPS J 15:951-961.

Crowell SR, Sharma AK, Amin S, Soelberg JJ, Sadler NC, Wright AT, Baird WM, Williams DE, Corley RA. (2013) Impact of pregnancy on the pharmacokinetics of dibenzo[def,p]chrysene in mice. Toxicol Sci 135:48-62.

Benninghoff AD, Williams DE. (2013) The role of estrogen receptor β in transplacental cancer prevention by indole-3-carbinol. Cancer Prev Res (Phila) 6:339-348.

Kaur P, Shorey LE, Ho E, Dashwood RH, Williams DE. (2013) The epigenome as a potential mediator of cancer and disease prevention in prenatal development. Nutr Rev 71:441-457.

Rajendran P, Kidane AI, Yu TW, Dashwood WM, Bisson WH, Löhr CV, Ho E, Williams DE, Dashwood RH. (2013) HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates. Epigenetics 8:612-623.

Shorey LE, Madeen EP, Atwell LL, Ho E, Löhr CV, Pereira CB, Dashwood RH, Williams DE. (2013) Differential modulation of dibenzo[def,p]chrysene transplacental carcinogenesis: maternal diets rich in indole-3-carbinol versus sulforaphane. Toxicol Appl Pharmacol 270:60-69.

Larkin A, Siddens LK, Krueger SK, Tilton SC, Waters KM, Williams DE, Baird WM. (2013) Application of a fuzzy neural network model in predicting polycyclic aromatic hydrocarbon-mediated perturbations of the Cyp1b1 transcriptional regulatory network in mouse skin. Toxicol Appl Pharmacol 267:192-199.

Wang R, Löhr CV, Fischer K, Dashwood WM, Greenwood JA, Ho E, Williams DE, Ashktorab H, Dashwood MR, Dashwood RH. (2013) Epigenetic inactivation of endothelin-2 and endothelin-3 in colon cancer. Int J Cancer 132:1004-1012.

Beaver LM, Yu TW, Sokolowski EI, Williams DE, Dashwood RH, Ho. (2012) 3,3'-Diindolylmethane, but not indole-3-carbinol, inhibits histone deacetylase activity in prostate cancer cells. Toxicol Appl Pharmacol 263:345-351.

Palmer AL, Leykam VL, Larkin A, Krueger SK, Phillips IR, Shephard EA, Williams DE. (2012) Metabolism and Pharmacokinetics of the Anti-Tuberculosis Drug Ethionamide in a Flavin-Containing Monooxygenase Null Mouse. Pharmaceuticals (Basel) 5:1147-1159.

Parasramka MA, Dashwood WM, Wang R, Saeed HH, Williams DE, Ho E, Dashwood RH. (2012) A role for low-abundance miRNAs in colon cancer: the miR-206/Krüppel-like factor 4 (KLF4) axis. Clin Epigenetics 4:16.

Siddens LK, Larkin A, Krueger SK, Bradfield CA, Waters KM, Tilton SC, Pereira CB, Löhr CV, Arlt VM, Phillips DH, Williams DE, Baird WM. (2012) Polycyclic aromatic hydrocarbons as skin carcinogens: comparison of benzo[a]pyrene, dibenzo[def,p]chrysene and three environmental mixtures in the FVB/N mouse. Toxicol Appl Pharmacol 264:377-386.

Parasramka MA, Dashwood WM, Wang R, Abdelli A, Bailey GS, Williams DE, Ho E, Dashwood RH. (2012) MicroRNA profiling of carcinogen-induced rat colon tumors and the influence of dietary spinach. Mol Nutr Food Res 56:1259-1269.

Shorey LE, Hagman AM, Williams DE, Ho E, Dashwood RH, Benninghoff AD. (2012) 3,3'-Diindolylmethane induces G1 arrest and apoptosis in human acute T-cell lymphoblastic leukemia cells. PLoS One 7:e34975.