|Title||α-Tocopherol adipose tissue stores are depleted after burn injury in pediatric patients.|
|Publication Type||Journal Article|
|Year of Publication||2010|
|Authors||Traber MG, Leonard SW, Traber DL, Traber LD, Gallagher J, Bobe G, Jeschke MG, Finnerty CC, Herndon D|
|Journal||Am J Clin Nutr|
|Date Published||2010 Dec|
|Keywords||Adipose Tissue, Adolescent, alpha-Tocopherol, Burns, Child, Child, Preschool, Female, Humans, Male, Reference Values, Regression Analysis, Triglycerides, Vitamin E Deficiency|
BACKGROUND: We previously showed that thermal injury depletes plasma vitamin E in pediatric burn patients; however, plasma changes may reflect immediate alterations in vitamin E nutriture. Adipose tissue α-tocopherol concentrations are generally accepted to reflect long-term vitamin E status.
OBJECTIVE: To test the hypothesis that thermal injury depletes body stores of vitamin E, α-tocopherol concentrations were measured in adipose tissue samples.
DESIGN: Pediatric patients (n = 8) were followed up to 1 y after burn injury. Surgically obtained samples were collected at various intervals and stored at -80°C in a biorepository. α- and γ-Tocopherols, cholesterol, and triglycerides were measured in the same tissue aliquot.
RESULTS: During the first week after injury, adipose tissue α-tocopherol concentrations were within the expected normal range of 199 ± 40 nmol/g adipose tissue but were substantially lower at weeks 2 and 3 (133 ± 13 and 109 ± 8 nmol/g adipose tissue, respectively). Individual rates of decrease, estimated by linear regression, showed that adipose tissue α-tocopherol decreased by an average of 6.1 ± 0.6 nmol/g daily. During the first month after injury, adipose tissue triglyceride concentrations also decreased, whereas no changes in cholesterol concentrations occurred.
CONCLUSIONS: These data emphasize that the burn injury experienced by these pediatric patients altered their metabolism such that vitamin E status diminished during the month after injury. Further studies are needed to evaluate the mechanism and consequences of the observed vitamin E depletion. This trial was registered at clinicaltrials.gov as NCT00675714.
|Alternate Journal||Am. J. Clin. Nutr.|
|PubMed Central ID||PMC2980963|
|Grant List||T32 GM-008256 / GM / NIGMS NIH HHS / United States |
P50-GM60338 / GM / NIGMS NIH HHS / United States
KL2RR029875 / RR / NCRR NIH HHS / United States
UL1 TR000071 / TR / NCATS NIH HHS / United States
P012 GM066312 / GM / NIGMS NIH HHS / United States
P50 GM060338 / GM / NIGMS NIH HHS / United States
DK 067930 / DK / NIDDK NIH HHS / United States
UL1 RR029876 / RR / NCRR NIH HHS / United States
UL1RR029876 / RR / NCRR NIH HHS / United States