Titleα-Tocopherol adipose tissue stores are depleted after burn injury in pediatric patients.
Publication TypeJournal Article
Year of Publication2010
AuthorsTraber MG, Leonard SW, Traber DL, Traber LD, Gallagher J, Bobe G, Jeschke MG, Finnerty CC, Herndon D
JournalAm J Clin Nutr
Date Published2010 Dec
KeywordsAdipose Tissue, Adolescent, alpha-Tocopherol, Burns, Child, Child, Preschool, Female, Humans, Male, Reference Values, Regression Analysis, Triglycerides, Vitamin E Deficiency

BACKGROUND: We previously showed that thermal injury depletes plasma vitamin E in pediatric burn patients; however, plasma changes may reflect immediate alterations in vitamin E nutriture. Adipose tissue α-tocopherol concentrations are generally accepted to reflect long-term vitamin E status.

OBJECTIVE: To test the hypothesis that thermal injury depletes body stores of vitamin E, α-tocopherol concentrations were measured in adipose tissue samples.

DESIGN: Pediatric patients (n = 8) were followed up to 1 y after burn injury. Surgically obtained samples were collected at various intervals and stored at -80°C in a biorepository. α- and γ-Tocopherols, cholesterol, and triglycerides were measured in the same tissue aliquot.

RESULTS: During the first week after injury, adipose tissue α-tocopherol concentrations were within the expected normal range of 199 ± 40 nmol/g adipose tissue but were substantially lower at weeks 2 and 3 (133 ± 13 and 109 ± 8 nmol/g adipose tissue, respectively). Individual rates of decrease, estimated by linear regression, showed that adipose tissue α-tocopherol decreased by an average of 6.1 ± 0.6 nmol/g daily. During the first month after injury, adipose tissue triglyceride concentrations also decreased, whereas no changes in cholesterol concentrations occurred.

CONCLUSIONS: These data emphasize that the burn injury experienced by these pediatric patients altered their metabolism such that vitamin E status diminished during the month after injury. Further studies are needed to evaluate the mechanism and consequences of the observed vitamin E depletion. This trial was registered at clinicaltrials.gov as NCT00675714.

Alternate JournalAm. J. Clin. Nutr.
PubMed ID20881067
PubMed Central IDPMC2980963
Grant ListT32 GM-008256 / GM / NIGMS NIH HHS / United States
P50-GM60338 / GM / NIGMS NIH HHS / United States
KL2RR029875 / RR / NCRR NIH HHS / United States
UL1 TR000071 / TR / NCATS NIH HHS / United States
P012 GM066312 / GM / NIGMS NIH HHS / United States
P50 GM060338 / GM / NIGMS NIH HHS / United States
DK 067930 / DK / NIDDK NIH HHS / United States
UL1 RR029876 / RR / NCRR NIH HHS / United States
UL1RR029876 / RR / NCRR NIH HHS / United States