Titleα-Tocopherol Pharmacokinetics in Adults with Cystic Fibrosis: Benefits of Supplemental Vitamin C Administration.
Publication TypeJournal Article
Year of Publication2022
AuthorsTraber MG, Leonard SW, Vasu VT, Morrissey BM, Lei HJohn, Atkinson J, Cross CE
Date Published2022 Sep 09
KeywordsAdult, alpha-Tocopherol, Ascorbic Acid, Cystic Fibrosis, gamma-Tocopherol, Humans, Tocopherols, Vitamin E, Vitamins

BACKGROUND: Numerous abnormalities in cystic fibrosis (CF) could influence tocopherol absorption, transportation, storage, metabolism and excretion. We hypothesized that the oxidative distress due to inflammation in CF increases vitamin E utilization, which could be positively influenced by supplemental vitamin C administration.

METHODS: Immediately before and after receiving vitamin C (500 mg) twice daily for 3.5 weeks, adult CF patients ( = 6) with moderately advanced respiratory tract (RT) disease consumed a standardized breakfast with 30% fat and a capsule containing 50 mg each hexadeuterium (d)-α- and dideuterium (d)-γ-tocopheryl acetates. Blood samples were taken frequently up to 72 h; plasma tocopherol pharmacokinetics were determined. During both trials, d-α- and d-γ-tocopherols were similarly absorbed and reached similar maximal plasma concentrations ~18-20 h. As predicted, during vitamin C supplementation, the rates of plasma d-α-tocopherol decline were significantly slower.

CONCLUSIONS: The vitamin C-induced decrease in the plasma disappearance rate of α-tocopherol suggests that vitamin C recycled α-tocopherol, thereby augmenting its concentrations. We conclude that some attention should be paid to plasma ascorbic acid concentrations in CF patients, particularly to those individuals with more advanced RT inflammatory disease and including those with severe exacerbations.

Alternate JournalNutrients
PubMed ID36145092
PubMed Central IDPMC9505313
Grant Listn/a / / Linus Pauling Institute, Oregon State University /
UL1 TR001860 / TR / NCATS NIH HHS / United States
n/a / / Cystic Fibrosis Foundation /
n/a / / UC Davis Center for Health and Nutrition Research Program /
155187 / / NSERC Discovery Grant /