TitleApplication of Paper Strip Extraction in Combination with LC-MS-MS in Pharmacokinetics.
Publication TypeJournal Article
Year of Publication2013
AuthorsLegette LCL, Reed RL, Murty L, Maier CS, Stevens JF
JournalSpectroscopy (Springf)
Date Published2013 Oct 01

Recent advances in sampling techniques in the pharmaceutical industry sparked significant interest in applying improvements to extraction methods for greater analyte detection and quantitation. In particular, the dried blood spot (DBS) sampling technique has numerous advantages compared to traditional methods such as liquid-liquid extraction, including the use of small sample volumes, less sample processing, and less exposure to toxic solvents (ether, methyl -butyl ether [MTBE], and dichloromethane). In this article, we discuss the adaptation of DBS technology to develop and validate a novel paper strip extraction method for the analysis of natural product metabolites in biological samples obtained from a human pharmacokinetic study of xanthohumol, a hop prenylflavonoid.

Alternate JournalSpectroscopy (Springf)
PubMed ID25328281
PubMed Central IDPMC4201118
Grant ListP30 ES000210 / ES / NIEHS NIH HHS / United States
R21 AT005294 / AT / NCCIH NIH HHS / United States
S10 RR022589 / RR / NCRR NIH HHS / United States
T32 AT002688 / AT / NCCIH NIH HHS / United States