TitleCaffeoylquinic Acids in Reverse Cognitive Deficits in Male 5XFAD Alzheimer's Disease Model Mice.
Publication TypeJournal Article
Year of Publication2020
AuthorsMatthews DG, Caruso M, Magana AAlcazar, Wright KM, Maier CS, Stevens JF, Gray NE, Quinn JF, Soumyanath A
Date Published2020 Nov 13

(CA) is an edible plant and a popular botanical dietary supplement. It is reputed, in Ayurveda, to mitigate age-related cognitive decline. There is a considerable body of preclinical literature supporting CA's ability to improve learning and memory. This study evaluated the contribution of CA's triterpenes (TT), widely considered its active compounds, and caffeoylquinic acids (CQA) to the cognitive effects of CA water extract (CAW) in 5XFAD mice, a model of Alzheimer's disease. 5XFAD mice were fed a control diet alone, or one containing 1% CAW or compound groups (TT, CQA, or TT + CQA) equivalent to their content in 1% CAW. Wild-type (WT) littermates received the control diet. Conditioned fear response (CFR) was evaluated after 4.5 weeks. Female 5XFAD controls showed no deficit in CFR compared to WT females, nor any effects from treatment. In males, CFR of 5XFAD controls was attenuated compared to WT littermates ( = 0.005). 5XFAD males receiving CQA or TT + CQA had significantly improved CFR ( < 0.05) compared to 5XFAD male controls. CFR did not differ between 5XFAD males receiving treatment diets and WT males. These data confirm a role for CQA in CAW's cognitive effects.

Alternate JournalNutrients
PubMed ID33202902
PubMed Central IDPMC7698091
Grant ListR01AT008099 / AT / NCCIH NIH HHS / United States
T32AT002688 / AT / NCCIH NIH HHS / United States
R00AT008831 / AT / NCCIH NIH HHS / United States
IO1BX003440 / / U.S. Department of Veterans Affairs /
S10RR027878 / NH / NIH HHS / United States