TitleChlorogenic Acids, Acting via Calcineurin, Are the Main Compounds in Extracts That Mediate Resilience to Chronic Stress in .
Publication TypeJournal Article
Year of Publication2023
AuthorsHolvoet H, Long DM, Yang L, Choi J, Marney L, Poeck B, Maier CS, Soumyanath A, Kretzschmar D, Strauss R
Date Published2023 Sep 16
KeywordsAnhedonia, Animals, Calcineurin, Centella, Chlorogenic Acid, Drosophila melanogaster, Plant Extracts, Resilience, Psychological, Triterpenes

Common symptoms of depressive disorders include anhedonia, sleep problems, and reduced physical activity. Drugs used to treat depression mostly aim to increase serotonin signaling but these can have unwanted side effects. Depression has also been treated by traditional medicine using plants like (CA) and this has been found to be well tolerated. However, very few controlled studies have addressed CA's protective role in depression, nor have the active compounds or mechanisms that mediate this function been identified. To address this issue, we used to investigate whether CA can improve depression-associated symptoms like anhedonia and decreased climbing activity. We found that a water extract of CA provides resilience to stress induced phenotypes and that this effect is primarily due to mono-caffeoylquinic acids found in CA. Furthermore, we describe that the protective function of CA is due to a synergy between chlorogenic acid and one of its isomers also present in CA. However, increasing the concentration of chlorogenic acid can overcome the requirement for the second isomer. Lastly, we found that chlorogenic acid acts via calcineurin, a multifunctional phosphatase that can regulate synaptic transmission and plasticity and is also involved in neuronal maintenance.

Alternate JournalNutrients
PubMed ID37764799
PubMed Central IDPMC10537055
Grant ListP40 OD018537 / OD / NIH HHS / United States
S10 OD026922 / OD / NIH HHS / United States
U19 AT010829 / AT / NCCIH NIH HHS / United States
U19AT010829 / AT / NCCIH NIH HHS / United States