TitleCigarette smoke alters human vitamin E requirements.
Publication TypeJournal Article
Year of Publication2005
AuthorsBruno RS, Traber MG
JournalJ Nutr
Date Published2005 Apr
KeywordsHumans, Lipid Peroxidation, Nutritional Requirements, Oxidative Stress, Smoking, Vitamin E

Vitamin E is a lipophilic chain-breaking antioxidant that prevents lipid peroxidation. Although cigarette smoke is a potent source of oxidative stress that depletes vitamin E in vitro, it is unclear whether it has a similar effect in vivo, particularly in humans. Therefore, this review will discuss the role of cigarette smoke on gamma-tocopherol (gamma-T) nitration, its effect on alpha-tocopherol (alpha-T) biokinetics in smokers, and the changes in the synthesis, plasma concentrations, and urinary excretion of the vitamin E metabolite (CEHC; carboxy-ethyl-hydroxy-chroman). Last, the possibility of CEHC as a biomarker of vitamin E status will be assessed as will the question whether smokers have increased dietary requirements of vitamin E.

Alternate JournalJ. Nutr.
PubMed ID15795416
Grant ListDK 59576 / DK / NIDDK NIH HHS / United States
P30 ES 00210 / ES / NIEHS NIH HHS / United States