TitleDietary manipulation of histone structure and function.
Publication TypeJournal Article
Year of Publication2008
AuthorsDelage B, Dashwood RH
JournalAnnu Rev Nutr
Volume28
Pagination347-66
Date Published2008
ISSN0199-9885
KeywordsAnimals, DNA Methylation, Epigenesis, Genetic, Female, Fetal Nutrition Disorders, Gene Expression Regulation, Gene Expression Regulation, Developmental, Gene Silencing, Histones, Humans, Male, Maternal Nutritional Physiological Phenomena, Pregnancy, Prenatal Exposure Delayed Effects, Prenatal Nutritional Physiological Phenomena
Abstract

Post-translational modifications of histones are the subject of intensive investigations with the aim of decoding how they regulate, alone or in combination, chromatin structure, genomic stability, and gene expression. Major epigenetic programming events take place during gametogenesis and fetal development and are thought to have long-lasting consequences on adult health. Epidemiological and experimental studies have pointed toward maternal nutrition as a major player during prenatal development in influencing disease susceptibility later in life. Although the mechanisms underlying such observations are not well elucidated, epigenetic alterations of histones by particular maternal diets might be of central importance. Moreover, as much as dietary sources can influence epigenetic programming during pregnancy, they have started to be implicated in cancer chemoprevention, via the targeting of reversible epigenetic deregulations at the level of the histones.

DOI10.1146/annurev.nutr.28.061807.155354
Alternate JournalAnnu. Rev. Nutr.
PubMed ID18598138
PubMed Central IDPMC2737739
Grant ListCA122959 / CA / NCI NIH HHS / United States
P01 CA090890 / CA / NCI NIH HHS / United States
P01 CA090890-01A20003 / CA / NCI NIH HHS / United States
CA90890 / CA / NCI NIH HHS / United States
R01 CA122959-02 / CA / NCI NIH HHS / United States
R29 CA065525 / CA / NCI NIH HHS / United States
R01 CA065525 / CA / NCI NIH HHS / United States
R01 CA122959 / CA / NCI NIH HHS / United States
CA65525 / CA / NCI NIH HHS / United States
R01 CA065525-06A1 / CA / NCI NIH HHS / United States
P01 CA090890-01A29001 / CA / NCI NIH HHS / United States