Title | Dietary resveratrol increases mid-life fecundity of female Nothobranchius guentheri. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Lee Y, Drake AC, Thomas NO, Ferguson LG, Chappell PE, Shay KPetersen |
Journal | Comp Biochem Physiol C Toxicol Pharmacol |
Volume | 208 |
Pagination | 71-76 |
Date Published | 2018 Jun |
ISSN | 1532-0456 |
Keywords | Age Factors, Animal Feed, Animals, Antioxidants, Body Weight, Diet, Female, Fertility, Fish Proteins, Fishes, Nicotinamide Phosphoribosyltransferase, Ovary, Resveratrol, Sexual Maturation, Sirtuin 1, Stilbenes |
Abstract | The decline of female reproductive function is an early phenotype of aging in humans, occurring only midway through the lifespan. Yet the number of women delaying pregnancy continues to rise in industrialized societies due to personal or socioeconomic circumstances, often resulting in subfertility or difficulty conceiving. There are few defined mechanisms associated with this etiology, and equally few effective therapies. To combat this problem, we used a novel emerging model, Nothobranchius guentheri, that recapitulates the age-associated spectrum of changes that adversely affect human fertility. We hypothesized that resveratrol (RSV), which activates SirT1 as an oxidative stress sensor and longevity assurance enzyme, would improve female fecundity in mid-life. RSV, a polyphenol found in grapes and red wine, has been touted as an anti-aging dietary supplement due to its ability to prolong both lifespan and health span. SirT1 is an NAD+ dependent histone deacetylase, whose activity is regulated by the nicotinamide to NAD+ salvage pathway, especially the rate-limiting enzyme NAMPT. We found that female N. guentheri fed 600μgRSV/g food into mid-life (~20weeks), beginning at sexual maturity, showed increased embryo production compared to those on Control diet. Furthermore, the RSV-fed fish had significantly increased NAMPT. This suggests that dietary RSV has a positive effect on female fertility, and that it may become an effective therapy to regulate sirtuin activity and combat reproductive senescence. |
DOI | 10.1016/j.cbpc.2017.10.006 |
Alternate Journal | Comp. Biochem. Physiol. C Toxicol. Pharmacol. |
PubMed ID | 29054583 |
PubMed Central ID | PMC5906208 |
Grant List | T32 AT002688 / AT / NCCIH NIH HHS / United States |