TitleDoes vitamin E decrease heart attack risk? summary and implications with respect to dietary recommendations.
Publication TypeJournal Article
Year of Publication2001
AuthorsTraber MG
JournalJ Nutr
Date Published2001 Feb
KeywordsAnimals, Antioxidants, Heart Diseases, Humans, Models, Animal, Nutrition Policy, Risk Factors, Vitamin E

The hypothesis that oxidative stress has a role in atherosclerosis rests on a large body of experimental work carried out in animal models of heart disease. The situation is more complex in humans, in that the results from vitamin E supplementation trials have been conflicting. Nonetheless, there is emerging information that alpha-tocopherol may play a critical role in maintaining the function of key cellular components in the atherosclerotic process through its ability to inhibit the activity of protein kinase C, a key player in many signal transduction pathways. alpha-Tocopherol modulates pathways of platelet aggregation, endothelial cell nitric oxide production, monocyte/macrophage superoxide production and smooth muscle cell proliferation. Regulation of adhesion molecule expression and inflammatory cell cytokine production by alpha-tocopherol has also been reported. More studies are required to relate alpha-tocopherol intakes to optimal tissue responses in humans.

Alternate JournalJ. Nutr.
PubMed ID11160568