TitleEpidermal Lipids: Key Mediators of Atopic Dermatitis Pathogenesis.
Publication TypeJournal Article
Year of Publication2019
AuthorsBhattacharya N, Sato WJ, Kelly A, Ganguli-Indra G, Indra AK
JournalTrends Mol Med
Date Published2019 06
KeywordsAnimals, Biomarkers, Ceramides, Dermatitis, Atopic, Disease Susceptibility, Epidermis, Gene Expression Regulation, Humans, Lipid Metabolism, Metabolic Networks and Pathways, T-Lymphocyte Subsets

The skin barrier keeps the 'inside in' and the 'outside out', forming a protective blanket against external insults. Epidermal lipids, such as ceramides, fatty acids (FAs), triglycerides, and cholesterol, are integral components driving the formation and maintenance of the epidermal permeability barrier (EPB). A breach in this lipid barrier sets the platform for the subsequent onset and progression of atopic dermatitis (AD). Such lipids are also important in the normal functioning of organisms, both plants and animals, and in diseases, including cancer. Given the doubling of the number of cases of AD in recent years and the chronic nature of this disorder, here we shed light on the multifaceted role of diverse types of lipid in mediating AD pathogenesis.

Alternate JournalTrends Mol Med
PubMed ID31054869
PubMed Central IDPMC6698381
Grant ListR01 AR056008 / AR / NIAMS NIH HHS / United States
R15 AR068584 / AR / NIAMS NIH HHS / United States