TitleEpigenetic Regulation by Sulforaphane: Opportunities for Breast and Prostate Cancer Chemoprevention.
Publication TypeJournal Article
Year of Publication2015
AuthorsAtwell LL, Beaver LM, Shannon J, Williams DE, Dashwood RH, Ho E
JournalCurr Pharmacol Rep
Date Published2015 Apr 01

Sulforaphane (SFN) is a phytochemical derived from cruciferous vegetables that has multiple molecular targets and anti-cancer properties. Researchers have demonstrated several chemopreventive benefits of SFN consumption, such as reductions in tumor growth, increases in cancer cell apoptosis, and disruption of signaling within tumor microenvironments both and . Emerging evidence indicates that SFN exerts several of its chemopreventive effects by altering epigenetic mechanisms. This review summarizes evidence of the impact of SFN on epigenetic events and how they relate to the chemopreventive effects of SFN observed in preclinical and clinical studies of breast and prostate cancers. Specific areas of focus include the role of SFN in the regulation of cell cycle, apoptosis, inflammation, antioxidant defense, and cancer cell signaling and their relationships to epigenetic mechanisms. Finally, remaining challenges and research needs for translating mechanistic work with SFN into human studies and clinical intervention trials are discussed.

Alternate JournalCurr Pharmacol Rep
PubMed ID26042194
PubMed Central IDPMC4450146
Grant ListP01 CA090890 / CA / NCI NIH HHS / United States
R01 CA122906 / CA / NCI NIH HHS / United States
R21 CA132236 / CA / NCI NIH HHS / United States