Linus Pauling Institute

Smith AR, Visioli F, Frei B, Hagen TM.  2008.  Lipoic acid significantly restores, in rats, the age-related decline in vasomotion.. Br J Pharmacol. 153(8):1615-22.

Loza AMárquez, Elias V, Wong CP, Ho E, Bermudez M, Magnusson KR.  2017.  Effects of ibuprofen on cognition and NMDA receptor subunit expression across aging.. Neuroscience. 344:276-292.

Niedzwiecki A, Fleming JE.  1993.  Heat shock induces changes in the expression and binding of ubiquitin in senescent Drosophila melanogaster.. Dev Genet. 14(1):78-86.

Smith AR, Hagen TM.  2003.  Vascular endothelial dysfunction in aging: loss of Akt-dependent endothelial nitric oxide synthase phosphorylation and partial restoration by (R)-alpha-lipoic acid.. Biochem Soc Trans. 31(Pt 6):1447-9.

Suh JH, Moreau R, Heath S-HD, Hagen TM.  2005.  Dietary supplementation with (R)-alpha-lipoic acid reverses the age-related accumulation of iron and depletion of antioxidants in the rat cerebral cortex.. Redox Rep. 10(1):52-60.

Mollusky A, Reynolds-Lallement N, Lee D, Zhong JY, Magnusson KR.  2024.  Investigating the effects of age and prior military service on fluid and crystallized cognitive functions using virtual morris water maze (vMWM) and NIH Toolbox tasks.. Arch Gerontol Geriatr. 116:105156.

Finlay LA, Michels AJ, Butler JA, Smith EJ, Monette JS, Moreau RF, Petersen SKate, Frei B, Hagen TM.  2012.  R-α-lipoic acid does not reverse hepatic inflammation of aging, but lowers lipid anabolism, while accentuating circadian rhythm transcript profiles.. Am J Physiol Regul Integr Comp Physiol. 302(5):R587-97.

Li L, Smith A, Hagen TM, Frei B.  2010.  Vascular oxidative stress and inflammation increase with age: ameliorating effects of alpha-lipoic acid supplementation.. Ann N Y Acad Sci. 1203:151-9.

Gómez LA, Hagen TM.  2012.  Age-related decline in mitochondrial bioenergetics: does supercomplex destabilization determine lower oxidative capacity and higher superoxide production? Semin Cell Dev Biol. 23(7):758-67.

Smith AR, Visioli F, Frei B, Hagen TM.  2006.  Age-related changes in endothelial nitric oxide synthase phosphorylation and nitric oxide dependent vasodilation: evidence for a novel mechanism involving sphingomyelinase and ceramide-activated phosphatase 2A.. Aging Cell. 5(5):391-400.

Iwaniec UT, Turner RT, Smith BJ, Stoecker BJ, Rust A, Zhang B, Vasu VT, Gohil K, Cross CE, Traber MG.  2013.  Evaluation of long-term vitamin E insufficiency or excess on bone mass, density, and microarchitecture in rodents.. Free Radic Biol Med. 65:1209-1214.

Smith AR, Visioli F, Hagen TM.  2006.  Plasma membrane-associated endothelial nitric oxide synthase and activity in aging rat aortic vascular endothelia markedly decline with age.. Arch Biochem Biophys. 454(1):100-5.

Hagen TM, Moreau R, Suh JH, Visioli F.  2002.  Mitochondrial decay in the aging rat heart: evidence for improvement by dietary supplementation with acetyl-L-carnitine and/or lipoic acid.. Ann N Y Acad Sci. 959:491-507.

Hall JA, Bobe G, Filley SJ, Pirelli GJ, Bohle MG, Wang G, T Davis Z, Bañuelos GS.  2023.  Effects of Amount and Chemical Form of Selenium Amendments on Forage Selenium Concentrations and Species Profiles.. Biol Trace Elem Res. 201(10):4951-4960.

Netke SP, Roomi MW, Tsao C, Niedzwiecki A.  1997.  Ascorbic acid protects guinea pigs from acute aflatoxin toxicity.. Toxicol Appl Pharmacol. 143(2):429-35.

Kubglomsong S, Theerakulkait C, Reed RL, Yang L, Maier CS, Stevens JF.  2018.  Isolation and Identification of Tyrosinase-Inhibitory and Copper-Chelating Peptides from Hydrolyzed Rice-Bran-Derived Albumin.. J Agric Food Chem. 66(31):8346-8354.

Lebold KM, Grant KA, Freeman WM, Wiren KM, Miller GW, Kiley C, Leonard SW, Traber MG.  2011.  Individual differences in hyperlipidemia and vitamin E status in response to chronic alcohol self-administration in cynomolgus monkeys.. Alcohol Clin Exp Res. 35(3):474-83.

Lebold KM, Grant KA, Freeman WM, Wiren KM, Miller GW, Kiley C, Leonard SW, Traber MG.  2011.  Individual differences in hyperlipidemia and vitamin E status in response to chronic alcohol self-administration in cynomolgus monkeys.. Alcohol Clin Exp Res. 35(3):474-83.

Kuiper HC, Miranda CL, Sowell JD, Stevens JF.  2008.  Mercapturic acid conjugates of 4-hydroxy-2-nonenal and 4-oxo-2-nonenal metabolites are in vivo markers of oxidative stress.. J Biol Chem. 283(25):17131-8.

Kuiper HC, Langsdorf BL, Miranda CL, Joss J, Jubert C, Mata JE, Stevens JF.  2010.  Quantitation of mercapturic acid conjugates of 4-hydroxy-2-nonenal and 4-oxo-2-nonenal metabolites in a smoking cessation study.. Free Radic Biol Med. 48(1):65-72.

Han B, Stevens JF, Maier CS.  2007.  Design, synthesis, and application of a hydrazide-functionalized isotope-coded affinity tag for the quantification of oxylipid-protein conjugates.. Anal Chem. 79(9):3342-54.

Miranda CL, Reed RL, Kuiper HC, Alber S, Stevens JF.  2009.  Ascorbic acid promotes detoxification and elimination of 4-hydroxy-2(E)-nonenal in human monocytic THP-1 cells.. Chem Res Toxicol. 22(5):863-74.

Moreau R, Heath S-HD, Doneanu CE, J Lindsay G, Hagen TM.  2003.  Age-related increase in 4-hydroxynonenal adduction to rat heart alpha-ketoglutarate dehydrogenase does not cause loss of its catalytic activity.. Antioxid Redox Signal. 5(5):517-27.

Sowell J, Frei B, Stevens JF.  2004.  Vitamin C conjugates of genotoxic lipid peroxidation products: structural characterization and detection in human plasma.. Proc Natl Acad Sci U S A. 101(52):17964-9.

Zhu B-Z, Carr AC, Frei B.  2002.  Pyrrolidine dithiocarbamate is a potent antioxidant against hypochlorous acid-induced protein damage.. FEBS Lett. 532(1-2):80-4.