|Title||Hemoglobin S polymerization and sickle cell disease: A retrospective on the occasion of the 70th anniversary of Pauling's Science paper.|
|Publication Type||Journal Article|
|Year of Publication||2020|
|Journal||Am J Hematol|
|Date Published||2020 02|
|Keywords||Anemia, Sickle Cell, Hemoglobin, Sickle, History, 20th Century, Humans, Periodicals as Topic, Polymerization|
70 years ago, Linus Pauling, the legendary genius of 20 century chemistry, published his famous work on the molecular cause of sickle cell disease, a paper that gave birth to what is now called molecular medicine. In this paper, Pauling left important questions unanswered that have motivated an enormous amount of scientific and clinical research since then. This retrospective discusses the basic science studies that have answered those questions directly related to the kinetics and thermodynamics of hemoglobin S polymerization.
|PubMed Central ID||PMC7003899|