OREGON STATE UNIVERSITY
Open search box
| Title | Improved in vivo targeting of BCL-2 phenotypic conversion through hollow gold nanoshell delivery. |
| Publication Type | Journal Article |
| Year of Publication | 2019 |
| Authors | Morgan E, Gamble JT, Pearce MC, Elson DJ, Tanguay RL, Kolluri SKumar, Reich NO |
| Journal | Apoptosis |
| Date Published | 2019 Mar 16 |
| ISSN | 1573-675X |
| Abstract | Although new cancer therapeutics are discovered at a rapid pace, lack of effective means of delivery and cancer chemoresistance thwart many of the promising therapeutics. We demonstrate a method that confronts both of these issues with the light-activated delivery of a Bcl-2 functional converting peptide, NuBCP-9, using hollow gold nanoshells. This approach has shown not only to increase the efficacy of the peptide 30-fold in vitro but also has shown to reduce paclitaxel resistant H460 lung xenograft tumor growth by 56.4%. |
| DOI | 10.1007/s10495-019-01531-1 |
| Alternate Journal | Apoptosis |
| PubMed ID | 30879165 |
| Grant List | R01 EB012637 / / National Institutes of Health / 5RO1ES016651 / / National Institutes of Health / W81XWH-08-1-0600 / / Medical Research and Material Command / W81XWH-12-1-0069 / / Medical Research and Material Command / RSG-13-132-01-CDD / / American Cancer Society / |