TitleImproved in vivo targeting of BCL-2 phenotypic conversion through hollow gold nanoshell delivery.
Publication TypeJournal Article
Year of Publication2019
AuthorsMorgan E, Gamble JT, Pearce MC, Elson DJ, Tanguay RL, Kolluri SKumar, Reich NO
Date Published2019 Mar 16

Although new cancer therapeutics are discovered at a rapid pace, lack of effective means of delivery and cancer chemoresistance thwart many of the promising therapeutics. We demonstrate a method that confronts both of these issues with the light-activated delivery of a Bcl-2 functional converting peptide, NuBCP-9, using hollow gold nanoshells. This approach has shown not only to increase the efficacy of the peptide 30-fold in vitro but also has shown to reduce paclitaxel resistant H460 lung xenograft tumor growth by 56.4%.

Alternate JournalApoptosis
PubMed ID30879165
Grant ListR01 EB012637 / / National Institutes of Health /
5RO1ES016651 / / National Institutes of Health /
W81XWH-08-1-0600 / / Medical Research and Material Command /
W81XWH-12-1-0069 / / Medical Research and Material Command /
RSG-13-132-01-CDD / / American Cancer Society /