TitleInfluence of cobalamin on the survival of mice bearing ascites tumor.
Publication TypeJournal Article
Year of Publication1993
AuthorsTsao CS, Myashita K
JournalPathobiology
Volume61
Issue2
Pagination104-8
Date Published1993
ISSN1015-2008
KeywordsAnimals, Body Weight, Cobamides, Female, Lethal Dose 50, Leukemia P388, Mice, Mice, Inbred DBA, Mice, Inbred Strains, Structure-Activity Relationship, Vitamin B 12
Abstract

The effect of cobalamin (vitamin B12) on the survival time of mice bearing P388 leukemia has been examined. Among the three cobalamins studied, the enzymatically active derivatives, methylcobalamin and 5'-deoxyadenosylcobalamin, were able to significantly increase the survival time of mice implanted intraperitoneally with the tumor cells. The pharmaceutical form, cyanocobalamin, was not active. The antitumor activity of these cobalamins may be associated with their functions in metabolism.
DOI10.1159/000163770
Alternate JournalPathobiology
PubMed ID8216825