Title | Lipid quantitation and metabolomics data from vitamin E-deficient and -sufficient zebrafish embryos from 0 to 120 hours-post-fertilization. |
Publication Type | Journal Article |
Year of Publication | 2017 |
Authors | McDougall M, Choi J, Kim H-K, Bobe G, J Stevens F, Cadenas E, Tanguay R, Traber MG |
Journal | Data Brief |
Volume | 11 |
Pagination | 432-441 |
Date Published | 2017 Apr |
ISSN | 2352-3409 |
Abstract | The data herein is in support of our research article by McDougall et al. (2017) [1], in which we used our zebrafish model of embryonic vitamin E (VitE) deficiency to study the consequences of VitE deficiency during development. Adult 5D wild-type zebrafish (), fed defined diets without (E-) or with VitE (E+, 500 mg -α-tocopheryl acetate/kg diet), were spawned to obtain E- and E+ embryos that we evaluated using metabolomics and specific lipid analyses (each measure at 24, 48, 72, 120 hours-post-fertilization, hpf), neurobehavioral development (locomotor responses at 96 hpf), and rescue strategies. Rescues were attempted using micro-injection into the yolksac using VitE (as a phospholipid emulsion containing d-α-tocopherol at 0 hpf) or -glucose (in saline at 24 hpf). |
DOI | 10.1016/j.dib.2017.02.046 |
Alternate Journal | Data Brief |
PubMed ID | 28280764 |
PubMed Central ID | PMC5334496 |
Grant List | P30 ES000210 / ES / NIEHS NIH HHS / United States S10 RR027878 / RR / NCRR NIH HHS / United States |