TitleLipid quantitation and metabolomics data from vitamin E-deficient and -sufficient zebrafish embryos from 0 to 120 hours-post-fertilization.
Publication TypeJournal Article
Year of Publication2017
AuthorsMcDougall M, Choi J, Kim H-K, Bobe G, J Stevens F, Cadenas E, Tanguay R, Traber MG
JournalData Brief
Date Published2017 Apr

The data herein is in support of our research article by McDougall et al. (2017) [1], in which we used our zebrafish model of embryonic vitamin E (VitE) deficiency to study the consequences of VitE deficiency during development. Adult 5D wild-type zebrafish (), fed defined diets without (E-) or with VitE (E+, 500 mg -α-tocopheryl acetate/kg diet), were spawned to obtain E- and E+ embryos that we evaluated using metabolomics and specific lipid analyses (each measure at 24, 48, 72, 120 hours-post-fertilization, hpf), neurobehavioral development (locomotor responses at 96 hpf), and rescue strategies. Rescues were attempted using micro-injection into the yolksac using VitE (as a phospholipid emulsion containing d-α-tocopherol at 0 hpf) or -glucose (in saline at 24 hpf).

Alternate JournalData Brief
PubMed ID28280764
PubMed Central IDPMC5334496
Grant ListP30 ES000210 / ES / NIEHS NIH HHS / United States
S10 RR027878 / RR / NCRR NIH HHS / United States