TitleOxidative stress in athletes during extreme endurance exercise.
Publication TypeJournal Article
Year of Publication2001
AuthorsMastaloudis A, Leonard SW, Traber MG
JournalFree Radic Biol Med
Date Published2001 Oct 01
KeywordsAdult, Ascorbic Acid, Exercise, F2-Isoprostanes, Female, Humans, Lipid Peroxidation, Lipids, Male, Middle Aged, Oxidative Stress, Physical Endurance, Sports, Uric Acid, Vitamin E

Despite the many known health benefits of exercise, there is a body of evidence suggesting that endurance exercise is associated with oxidative stress. To determine whether extreme endurance exercise induces lipid peroxidation, 11 athletes (3 females, 8 males) were studied during a 50 km ultramarathon (trial 1) and during a sedentary protocol (trial 2) 1 month later. The evening before each trial, with dinner, subjects consumed 75 mg each d(3)-RRR and d(6)-all rac-alpha-tocopheryl acetates. Blood was obtained at baseline, 30 min pre-race, mid-race, post-race, 1 h post-race, 24 h post-race, and at corresponding times during trial 2. All 11 subjects completed the race; average run time was 391 +/- 23 min. Plasma F(2)-isoprostanes increased from 75 +/- 7 pg/ml at pre-race to 131 +/- 17 (p <.02) at post-race, then returned to baseline at 24 h post-race; F(2)-isoprostanes were unchanged during trial 2. Deuterated alpha-tocopherol disappearance rates were faster (2.8 x 10(-4) +/- 0.2 x 10(-4)) during the race compared to the sedentary trial (2.3 x 10(-4) +/- 0.2 x 10(-4); p <.03). These data suggest that extreme endurance exercise results in the generation of lipid peroxidation with a concomitant increase in vitamin E disappearance.

Alternate JournalFree Radic. Biol. Med.
PubMed ID11585710
Grant ListR03 ES011536 / ES / NIEHS NIH HHS / United States
ES 00210 / ES / NIEHS NIH HHS / United States