TitleThe Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution.
Publication TypeJournal Article
Year of Publication2019
AuthorsTaylor DM, Aronow BJ, Tan K, Bernt K, Salomonis N, Greene CS, Frolova A, Henrickson SE, Wells A, Pei L, Jaiswal JK, Whitsett J, Hamilton KE, MacParland SA, Kelsen J, Heuckeroth RO, S Potter S, Vella LA, Terry NA, Ghanem LR, Kennedy BC, Helbig I, Sullivan KE, Castelo-Soccio L, Kreigstein A, Herse F, Nawijn MC, Koppelman GH, Haendel M, Harris NL, Rokita JLynne, Zhang Y, Regev A, Rozenblatt-Rosen O, Rood JE, Tickle TL, Vento-Tormo R, Alimohamed S, Lek M, Mar JC, Loomes KM, Barrett DM, Uapinyoying P, Beggs AH, Agrawal PB, Chen Y-W, Muir AB, Garmire LX, Snapper SB, Nazarian J, Seeholzer SH, Fazelinia H, Singh LN, Faryabi RB, Raman P, Dawany N, Xie HMichael, Devkota B, Diskin SJ, Anderson SA, Rappaport EF, Peranteau W, Wikenheiser-Brokamp KA, Teichmann S, Wallace D, Peng T, Ding Y-Y, Kim MS, Xing Y, Kong SWon, Bönnemann CG, Mandl KD, White PS
JournalDev Cell
Volume49
Issue1
Pagination10-29
Date Published2019 Apr 08
ISSN1878-1551
Abstract

Single-cell gene expression analyses of mammalian tissues have uncovered profound stage-specific molecular regulatory phenomena that have changed the understanding of unique cell types and signaling pathways critical for lineage determination, morphogenesis, and growth. We discuss here the case for a Pediatric Cell Atlas as part of the Human Cell Atlas consortium to provide single-cell profiles and spatial characterization of gene expression across human tissues and organs. Such data will complement adult and developmentally focused HCA projects to provide a rich cytogenomic framework for understanding not only pediatric health and disease but also environmental and genetic impacts across the human lifespan.
DOI10.1016/j.devcel.2019.03.001
Alternate JournalDev. Cell
PubMed ID30930166
Grant ListR01 DK111495 / DK / NIDDK NIH HHS / United States
U2C HL138346 / HL / NHLBI NIH HHS / United States
R01 LM012373 / LM / NLM NIH HHS / United States
R01 AR044345 / AR / NIAMS NIH HHS / United States
P30 DK078392 / DK / NIDDK NIH HHS / United States
U19 MH104172 / MH / NIMH NIH HHS / United States
U01 HL122638 / HL / NHLBI NIH HHS / United States
R03 DK114463 / DK / NIDDK NIH HHS / United States
U01 CA226187 / CA / NCI NIH HHS / United States
K01 DK100485 / DK / NIDDK NIH HHS / United States
K08 AI135091 / AI / NIAID NIH HHS / United States
K12 HD043245 / HD / NICHD NIH HHS / United States
R01 MH107205 / MH / NIMH NIH HHS / United States
R01 HD084633 / HD / NICHD NIH HHS / United States
R01 HG010067 / HG / NHGRI NIH HHS / United States
P20 GM103457 / GM / NIGMS NIH HHS / United States
U2C CA233285 / CA / NCI NIH HHS / United States
K01 ES025434 / ES / NIEHS NIH HHS / United States
P01 HD070454 / HD / NICHD NIH HHS / United States
U01 HL122642 / HL / NHLBI NIH HHS / United States
U01 CA226196 / CA / NCI NIH HHS / United States