TitlePerspective: Council for Responsible Nutrition Science in Session. Optimizing Health with Nutrition-Opportunities, Gaps, and the Future.
Publication TypeJournal Article
Year of Publication2023
AuthorsHo E, Drake VJ, Michels AJ, Nkrumah-Elie YM, Brown LVL, Scott JM, Newman JW, Shukitt-Hale B, Soumyanath A, Chilton FH, Lindemann SR, Shao A, Mitmesser SHazels
JournalAdv Nutr
Date Published2023 Sep
KeywordsBiomarkers, Gastrointestinal Microbiome, Humans, Nutritional Sciences, Nutritional Status

Achieving optimal health is an aspirational goal for the population, yet the definition of health remains unclear. The role of nutrition in health has evolved beyond correcting malnutrition and specific deficiencies and has begun to focus more on achieving and maintaining 'optimal' health through nutrition. As such, the Council for Responsible Nutrition held its October 2022 Science in Session conference to advance this concept. Here, we summarize and discuss the findings of their Optimizing Health through Nutrition - Opportunities and Challenges workshop, including several gaps that need to be addressed to advance progress in the field. Defining and evaluating various indices of optimal health will require overcoming these key gaps. For example, there is a strong need to develop better biomarkers of nutrient status, including more accurate markers of food intake, as well as biomarkers of optimal health that account for maintaining resilience-the ability to recover from or respond to stressors without loss to physical and cognitive performance. In addition, there is a need to identify factors that drive individualized responses to nutrition, including genotype, metabotypes, and the gut microbiome, and to realize the opportunity of precision nutrition for optimal health. This review outlines hallmarks of resilience, provides current examples of nutritional factors to optimize cognitive and performance resilience, and gives an overview of various genetic, metabolic, and microbiome determinants of individualized responses.

Alternate JournalAdv Nutr
PubMed ID37270030
PubMed Central IDPMC10509435
Grant ListU19 AT010829 / AT / NCCIH NIH HHS / United States
R61 AT009628 / AT / NCCIH NIH HHS / United States
R01 AT008621 / AT / NCCIH NIH HHS / United States
R35 GM133634 / GM / NIGMS NIH HHS / United States