TitlePhytochemical characterization of root bark and its effects on dysfunctional metabolism and cognitive performance in high-fat-fed C57BL/6J mice.
Publication TypeJournal Article
Year of Publication2018
AuthorsBading-Taika B, Akinyeke T, Magana AAlcazar, Choi J, Ouanesisouk M, Torres ERuth Samso, Lione LA, Maier CS, Bobe G, Raber J, Miranda CL, Stevens JF
JournalJ Food Bioact
Date Published2018 Sep

Preparations of the root bark of have long been used in Central and West African traditional medicine to combat fatigue, as a neuro-stimulant in rituals, and for treatment of diabetes. The principal alkaloid of ibogaine, has attracted attention in many countries around the world for providing relief for opioid craving in drug addicts. Using a plant metabolomics approach, we detected five phenolic compounds, including 3--caffeoylquinic acid, and 30 alkaloids, seven of which were previously reported from root bark. Following a report that iboga extracts contain insulinotropic agents, we aimed to determine the potential alleviating effects of the water extract of iboga root bark on high-fat diet (HFD)-induced hyperglycemia as well as its effects on cognitive function in male C57BL/6J mice. Feeding a HFD to mice for 10 weeks produced manifestations of metabolic syndrome such as increased body weight and increased plasma levels of glucose, triacylglycerols, total cholesterol, LDL-cholesterol, insulin, leptin, and pro-inflammatory mediators (IL-6, MCP-1, ICAM-1), as compared to mice fed a low-fat diet (LFD). Supplementation of HFD with iboga extract at ibogaine doses of 0.83 (low) and 2.07 (high) mg/kg/day did not improve these HFD-induced metabolic effects except for a reduction of plasma MCP-1 in the low dose group, indicative of an anti-inflammatory effect. When the HFD mice were tested in the water maze, the high-dose iboga extract caused hippocampus-dependent impairments in spatial learning and memory, as compared to mice receiving only a HFD.

Alternate JournalJ Food Bioact
PubMed ID30582133
PubMed Central IDPMC6301038
Grant ListS10 RR027878 / RR / NCRR NIH HHS / United States
T32 ES007060 / ES / NIEHS NIH HHS / United States
T32 HL094294 / HL / NHLBI NIH HHS / United States