|Post-initiation chlorophyllin exposure does not modulate aflatoxin-induced foci in the liver and colon of rats.
|Year of Publication
|Orner GA, Roebuck BD, Dashwood RH, Bailey GS
|2006 Feb 06
Chlorophyllin (CHL) is a promising chemopreventive agent believed to block cancer primarily by inhibiting carcinogen uptake through the formation of molecular complexes with the carcinogens. However, recent studies suggest that CHL may have additional biological effects particularly when given after the period of carcinogen treatment. This study examines the post-initiation effects of CHL towards aflatoxin B1 (AFB1)-induced preneoplastic foci of the liver and colon. The single concentration of CHL tested in this study (0.1% in the drinking water) had no significant effects on AFB1-induced foci of the liver and colons of rats.
|PubMed Central ID
|P01 CA090890 / CA / NCI NIH HHS / United States
P30 ES003850 / ES / NIEHS NIH HHS / United States
R29 CA065525 / CA / NCI NIH HHS / United States
R01 CA065525 / CA / NCI NIH HHS / United States
R21 CA100608 / CA / NCI NIH HHS / United States
P30 ES000210 / ES / NIEHS NIH HHS / United States