TitleResearch gaps and opportunities in precision nutrition: an NIH workshop report.
Publication TypeJournal Article
Year of Publication2022
AuthorsLee BY, Ordovás JM, Parks EJ, Anderson CAM, Barabási A-L, Clinton SK, de la Haye K, Duffy VB, Franks PW, Ginexi EM, Hammond KJ, Hanlon EC, Hittle M, Ho E, Horn AL, Isaacson RS, Mabry PL, Malone S, Martin CK, Mattei J, Meydani SNikbin, Nelson LM, Neuhouser ML, Parent B, Pronk NP, Roche HM, Saria S, Scheer FAJL, Segal E, Sevick MAnn, Spector TD, Van Horn L, Varady KA, Voruganti VSaroja, Martinez MF
JournalAm J Clin Nutr
Date Published2022 Dec 19
KeywordsDiet, Evidence Gaps, Humans, National Institutes of Health (U.S.), Nutrigenomics, Nutritional Status, Precision Medicine, United States

Precision nutrition is an emerging concept that aims to develop nutrition recommendations tailored to different people's circumstances and biological characteristics. Responses to dietary change and the resulting health outcomes from consuming different diets may vary significantly between people based on interactions between their genetic backgrounds, physiology, microbiome, underlying health status, behaviors, social influences, and environmental exposures. On 11-12 January 2021, the National Institutes of Health convened a workshop entitled "Precision Nutrition: Research Gaps and Opportunities" to bring together experts to discuss the issues involved in better understanding and addressing precision nutrition. The workshop proceeded in 3 parts: part I covered many aspects of genetics and physiology that mediate the links between nutrient intake and health conditions such as cardiovascular disease, Alzheimer disease, and cancer; part II reviewed potential contributors to interindividual variability in dietary exposures and responses such as baseline nutritional status, circadian rhythm/sleep, environmental exposures, sensory properties of food, stress, inflammation, and the social determinants of health; part III presented the need for systems approaches, with new methods and technologies that can facilitate the study and implementation of precision nutrition, and workforce development needed to create a new generation of researchers. The workshop concluded that much research will be needed before more precise nutrition recommendations can be achieved. This includes better understanding and accounting for variables such as age, sex, ethnicity, medical history, genetics, and social and environmental factors. The advent of new methods and technologies and the availability of considerably more data bring tremendous opportunity. However, the field must proceed with appropriate levels of caution and make sure the factors listed above are all considered, and systems approaches and methods are incorporated. It will be important to develop and train an expanded workforce with the goal of reducing health disparities and improving precision nutritional advice for all Americans.

Alternate JournalAm J Clin Nutr
PubMed ID36055772
PubMed Central IDPMC9761773
Grant ListF32 HD008686 / HD / NICHD NIH HHS / United States
U54 TR004279 / TR / NCATS NIH HHS / United States
5T32HL151323-02 / HL / NHLBI NIH HHS / United States
T32 HL151323 / HL / NHLBI NIH HHS / United States