TitleStrategies to protect against age-related mitochondrial decay: Do natural products and their derivatives help?
Publication TypeJournal Article
Year of Publication2022
AuthorsVisioli F, Ingram A, Beckman JS, Magnusson KR, Hagen TM
JournalFree Radic Biol Med
Date Published2022 Jan
KeywordsAnimals, Antioxidants, Biological Products, Humans, Mitochondria, Mitophagy, Oxidative Stress

Mitochondria serve vital roles critical for overall cellular function outside of energy transduction. Thus, mitochondrial decay is postulated to be a key factor in aging and in age-related diseases. Mitochondria may be targets of their own decay through oxidative damage. However, treating animals with antioxidants has been met with only limited success in rejuvenating mitochondrial function or in increasing lifespan. A host of nutritional strategies outside of using traditional antioxidants have been devised to promote mitochondrial function. Dietary compounds are under study that induce gene expression, enhance mitochondrial biogenesis, mitophagy, or replenish key metabolites that decline with age. Moreover, redox-active compounds may now be targeted to mitochondria which improve their effectiveness. Herein we review the evidence that representative dietary effectors modulate mitochondrial function by stimulating their renewal or reversing the age-related loss of key metabolites. While in vitro evidence continues to accumulate that many of these compounds benefit mitochondrial function and/or prevent their decay, the results using animal models and, in some instances human clinical trials, are more mixed and sometimes even contraindicated. Thus, further research on optimal dosage and age of intervention are warranted before recommending potential mitochondrial rejuvenating compounds for human use.

Alternate JournalFree Radic Biol Med
PubMed ID34890770
Grant ListR21 AG060206 / AG / NIA NIH HHS / United States