Title | Synthetic as compared with natural vitamin E is preferentially excreted as alpha-CEHC in human urine: studies using deuterated alpha-tocopheryl acetates. |
Publication Type | Journal Article |
Year of Publication | 1998 |
Authors | Traber MG, Elsner A, Brigelius-Flohé R |
Journal | FEBS Lett |
Volume | 437 |
Issue | 1-2 |
Pagination | 145-8 |
Date Published | 1998 Oct 16 |
ISSN | 0014-5793 |
Keywords | Adult, alpha-Tocopherol, Chromans, Deuterium, Female, Humans, Male, Middle Aged, Propionates, Tocopherols, Vitamin E |
Abstract | Alpha-CEHC (2,5,7,8-tetramethyl-2(2'-carboxyethyl)-6-hydroxychroman) is a urinary vitamin E metabolite with a truncated phytyl tail. To test whether natural and synthetic vitamin E are similarly converted to alpha-CEHC, 6 humans consumed 150 mg each RRR-alpha-[5-(C2H3)]- and all rac-alpha-[5,7(C2H3)2]-tocopheryl acetates (d3RRR-alpha- and d6all rac-alpha-tocopheryl acetates, respectively). Plasma was collected at 0, 6, 12 and 24 h; urine (24 h) at 0, 1, 2, 3, 4 and 8 days. Following dosing, plasma was enriched with d3RRR-alpha-tocopherol, while urine was enriched with alpha-CEHC derived from d6all rac-alpha-tocopherol. Thus, synthetic compared with natural vitamin E is preferentially metabolized to alpha-CEHC and excreted. |
DOI | 10.1016/s0014-5793(98)01210-1 |
Alternate Journal | FEBS Lett. |
PubMed ID | 9804189 |