OREGON STATE UNIVERSITY
Open search box
| Title | Tea catechins inhibit hepatocyte growth factor receptor (MET kinase) activity in human colon cancer cells: kinetic and molecular docking studies. |
| Publication Type | Journal Article |
| Year of Publication | 2009 |
| Authors | Larsen CA, Bisson WH, Dashwood RH |
| Journal | J Med Chem |
| Volume | 52 |
| Issue | 21 |
| Pagination | 6543-5 |
| Date Published | 2009 Nov 12 |
| ISSN | 1520-4804 |
| Keywords | Antineoplastic Agents, Camellia sinensis, Catechin, Cell Line, Tumor, Colonic Neoplasms, Drug Screening Assays, Antitumor, Flavonoids, Gallic Acid, Humans, Kinetics, Models, Molecular, Phenols, Polyphenols, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-met, Receptors, Growth Factor, Structure-Activity Relationship |
| Abstract | Most cancer deaths result from spread of the primary tumor to distant sites (metastasis). MET is an important protein for metastasis in multiple tumor types. Here we report on the ability of tea catechins to suppress MET activation in human colon cancer cells and propose a mechanism by which they might compete for the kinase domain of the MET protein. |
| DOI | 10.1021/jm901330e |
| Alternate Journal | J. Med. Chem. |
| PubMed ID | 19839593 |
| PubMed Central ID | PMC2784189 |
| Grant List | CA122959 / CA / NCI NIH HHS / United States P01 CA090890 / CA / NCI NIH HHS / United States P01 CA090890-01A20003 / CA / NCI NIH HHS / United States R01 CA122959-02 / CA / NCI NIH HHS / United States R29 CA065525 / CA / NCI NIH HHS / United States CA090890 / CA / NCI NIH HHS / United States R01 CA065525 / CA / NCI NIH HHS / United States R01 CA122959 / CA / NCI NIH HHS / United States CA65525 / CA / NCI NIH HHS / United States R01 CA065525-10 / CA / NCI NIH HHS / United States |