TitleTea catechins as inhibitors of receptor tyrosine kinases: mechanistic insights and human relevance.
Publication TypeJournal Article
Year of Publication2010
AuthorsLarsen CA, Dashwood RH, Bisson WH
JournalPharmacol Res
Volume62
Issue6
Pagination457-64
Date Published2010 Dec
ISSN1096-1186
KeywordsAnimals, Anticarcinogenic Agents, Catechin, Humans, Neoplasms, Receptor Protein-Tyrosine Kinases, Tea
Abstract

Receptor tyrosine kinases (RTKs) play important roles in the control of fundamental cellular processes, influencing the balance between cell proliferation and death. RTKs have emerged as molecular targets for the treatment of various cancers. Green tea and its polyphenolic compounds, the catechins, exhibit chemopreventive and chemotherapeutic properties in many human cancer cell types, as well as in various carcinogenicity models in vivo. Epidemiological studies are somewhat less convincing, but some positive correlations have been observed. The tea catechins, including (-)-epigallocatechin-3-gallate (EGCG), have pleiotropic effects on cellular proteins and signaling pathways. This review focuses on the ability of the tea constituents to suppress RTK signaling, and summarizes the mechanisms by which EGCG and other catechins might exert their protective effects towards dysregulated RTKs in cancer cells. The findings are discussed in the context of ongoing clinical trials with RTK inhibitors, and the possibility for drug/nutrient interactions enhancing therapeutic efficacy.

DOI10.1016/j.phrs.2010.07.010
Alternate JournalPharmacol. Res.
PubMed ID20691268
PubMed Central IDPMC2974766
Grant ListCA122959 / CA / NCI NIH HHS / United States
P01 CA090890 / CA / NCI NIH HHS / United States
P01 CA090890-06A26525 / CA / NCI NIH HHS / United States
CA90890 / CA / NCI NIH HHS / United States
ES00210 / ES / NIEHS NIH HHS / United States
R01 CA122959-04 / CA / NCI NIH HHS / United States
R01 CA065525 / CA / NCI NIH HHS / United States
R01 CA122959 / CA / NCI NIH HHS / United States
R01 CA065525-10 / CA / NCI NIH HHS / United States
P01 CA090890-01A29001 / CA / NCI NIH HHS / United States
R01 CA122959-03 / CA / NCI NIH HHS / United States
P01 CA090890-06A26523 / CA / NCI NIH HHS / United States
P01 CA090890-07 / CA / NCI NIH HHS / United States
P30 ES000210 / ES / NIEHS NIH HHS / United States